Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial

Autor: Davies, A, Cummin, TE, Barrans, S, Maishman, T, Mamot, C, Novak, U, Caddy, J, Stanton, L, Kazmi-Stokes, S, McMillan, A, Fields, P, Pocock, C, Collins, GP, Stephens, R, Cucco, F, Clipson, A, Sha, C, Tooze, R, Care, MA, Griffiths, G, Du, M-Q, Westhead, DR, Burton, C, Johnson, PWM

Publikováno v: Davies, Andrew; Cummin, Thomas E; Barrans, Sharon; Maishman, Tom; Mamot, Christoph; Novak, Urban; Caddy, Josh; Stanton, Louise; Kazmi-Stokes, Shamim; McMillan, Andrew; Fields, Paul; Pocock, Christopher; Collins, Graham P; Stephens, Richard; Cucco, Francesco; Clipson, Alexandra; Sha, Chulin; Tooze, Reuben; Care, Matthew A; Griffiths, Gareth; ... (2019). Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial. The lancet oncology, 20(5), pp. 649-662. Elsevier 10.1016/S1470-2045(18)30935-5

BACKGROUND: Biologically distinct subtypes of diffuse large B-cell lymphoma can be identified using gene-expression analysis to determine their cell of origin, corresponding to germinal centre or activated B cell. We aimed to investigate whether addi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca200ca0986b184f9bd9d47ac4e133

Network analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity

Autor: Care, MA, Stephenson, SJ, Barnes, NA, Fan, I, Zougman, A, El-Sherbiny, YM, Vital, EM, Westhead, DR, Tooze, RM, Doody, GM

Publikováno v: Care, M A, Stephenson, S J, Barnes, N A, Fan, I, Zougman, A, El-Sherbiny, Y M, Vital, E M, Westhead, D R, Tooze, R M & Doody, G M 2016, ' Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity ', Journal of immunology (Baltimore, Md. : 1950), vol. 197, no. 4, pp. 1447-59 . https://doi.org/10.4049/jimmunol.1600624

Plasma cells (PCs) as effectors of humoral immunity produce Igs to match pathogenic insult. Emerging data suggest more diverse roles exist for PCs as regulators of immune and inflammatory responses via secretion of factors other than Igs. The extent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::794912401d9c8cef1c3d4bd97cec5b72

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy.

Autor: Tanner G; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Barrow R; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Ajaib S; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Al-Jabri M; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Ahmed N; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Pollock S; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Finetti M; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Rippaus N; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Bruns AF; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Syed K; The Walton Centre NHS Foundation Trust, Liverpool, UK., Poulter JA; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Matthews L; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Hughes T; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.; School of Science, Technology and Health, York St John University, York, YO31 7EX, UK., Wilson E; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Johnson C; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Varn FS; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Brüning-Richardson A; School of Applied Sciences, University of Huddersfield, Huddersfield, UK., Hogg C; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Droop A; Welcome Sanger Institute, Hinxton, Saffron Walden, UK., Gusnanto A; School of Mathematics, University of Leeds, Leeds, UK., Care MA; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Cutillo L; School of Mathematics, University of Leeds, Leeds, UK., Westhead DR; School of Molecular and Cellular Biology, University of Leeds, Leeds, UK., Short SC; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.; Leeds Teaching Hospital, Leeds, UK., Jenkinson MD; The Walton Centre NHS Foundation Trust, Liverpool, UK.; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Brodbelt A; The Walton Centre NHS Foundation Trust, Liverpool, UK., Chakrabarty A; Leeds Teaching Hospital, Leeds, UK., Ismail A; Leeds Teaching Hospital, Leeds, UK., Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Yale School of Medicine, New Haven, CT, USA., Stead LF; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. l.f.stead@leeds.ac.uk.

Publikováno v: Genome biology [Genome Biol] 2024 Feb 07; Vol. 25 (1), pp. 45. Date of Electronic Publication: 2024 Feb 07.

Spontaneous EBV-Reactivation during B Cell Differentiation as a Model for Polymorphic EBV-Driven Lymphoproliferation.

Autor: Care MA; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds LS9 7TF, UK.; Bioinformatics Group, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Stephenson S; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds LS9 7TF, UK., Owen R; Haematological Malignancy Diagnostic Service, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK., Doody GM; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds LS9 7TF, UK., Tooze RM; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds LS9 7TF, UK.; Haematological Malignancy Diagnostic Service, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK.

Publikováno v: Cancers [Cancers (Basel)] 2023 Jun 07; Vol. 15 (12). Date of Electronic Publication: 2023 Jun 07.

A System for In Vitro Generation of Mature Murine Plasma Cells Uncovers Differential Blimp-1 / Prdm1 Promoter Usage.

Autor: Robinson E; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, United Kingdom; and., Care MA; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, United Kingdom; and., Walker K; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, United Kingdom; and., Campbell M; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, United Kingdom; and., Tooze RM; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, United Kingdom; and.; Haematological Malignancy Diagnostic Service, St James's Institute of Oncology, Leeds, United Kingdom., Doody GM; Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, United Kingdom; and g.m.doody@leeds.ac.uk.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Jan 15; Vol. 208 (2), pp. 514-525. Date of Electronic Publication: 2021 Dec 15.