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Activation priming and cytokine polyfunctionality modulate the enhanced functionality of low-affinity CD19 CAR T cells.

Autor: Michelozzi IM; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Gomez-Castaneda E; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Pohle RVC; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Cardoso Rodriguez F; Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, United Kingdom., Sufi J; Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, United Kingdom., Puigdevall Costa P; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Subramaniyam M; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Kirtsios E; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Eddaoudi A; Flow Cytometry Core Facility, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Wu SW; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Guvenel A; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Fisher J; Developmental Biology and Cancer Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Ghorashian S; Developmental Biology and Cancer Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Pule MA; Cancer Institute, University College London, London, United Kingdom., Tape CJ; Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, United Kingdom., Castellano S; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.; UCL Genomics, Zayed Centre for Research into Rare Disease in Children, University College London, London, United Kingdom., Amrolia PJ; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.; Department of Bone Marrow Transplant, Great Ormond Street Hospital for Children, London, United Kingdom., Giustacchini A; Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Publikováno v: Blood advances [Blood Adv] 2023 May 09; Vol. 7 (9), pp. 1725-1738.