Výsledky vyhledávání - "Cardiovascular and Pulmonary Pharmacology"

PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells

Autor: Callister, M E, Pinhu, L, Catley, M C, Westwell, A D, Newton, R, Leaver, S K, Quinlan, G J, Evans, T W, Griffiths, M J, Burke-Gaffney, A

Publikováno v: British Journal of Pharmacology

Background and purpose: Subtle changes in the intracellular reduction–oxidation (redox) state can modulate nuclear factor-κB (NF-κB) activity. Thioredoxin-1 (Trx) is a small, ubiquitous, redox-active thiol (-SH) protein that, with thioredoxin red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed36c6982340b21161e2746e7f301d0b
http://europepmc.org/articles/PMC2442904

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Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats

Autor: Jolly, L, March, J E, Kemp, P A, Bennett, T, Gardiner, S M

Publikováno v: British Journal of Pharmacology

Background and purpose: Studies using adenosine receptor antagonists have shown that adenosine-mediated vasodilatations play an important role in the maintenance of regional perfusion during sepsis, but it is unclear whether vascular sensitivity to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b45083429ddf528eae485494967156c
http://europepmc.org/articles/PMC2440086

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Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells

Autor: A, Banerjee, G, Damera, R, Bhandare, S, Gu, Ys, Lopez-Boado, Ra, Panettieri, O, Tliba

Publikováno v: British Journal of Pharmacology

Background and purpose: Chemokines play a critical role in the pathogenesis of asthma and facilitate the recruitment of inflammatory cells in the airways. Evidence now suggests that airway smooth muscle (ASM) may serve as a source of chemokines in in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::044b74bfad68ebcabe40aa4f7b16b252
https://pubmed.ncbi.nlm.nih.gov/18552877

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Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

Autor: H R, Lu, E, Vlaminckx, A N, Hermans, J, Rohrbacher, K, Van Ammel, R, Towart, M, Pugsley, D J, Gallacher

Publikováno v: British Journal of Pharmacology

Background and purpose: The regulatory guidelines (ICHS7B) recommending inhibition of the delayed rectifier K+ current (IKr), carried by human ether-a-go-go-related gene (hERG) channels in cardiac cells (the hERG test), as a ‘first line' test for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::663099a58202ca8cac96bb3874c2a32a
https://pubmed.ncbi.nlm.nih.gov/18493243

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