Zobrazeno 1 - 10
of 1 754
pro vyhledávání: '"Cardiomyocyte hypertrophy"'
Autor:
Bin-Bin Zhang, Yi-Lin Zhao, Yan-Yu Lu, Ji-Hong Shen, Hui-Yong Li, Han-Xue Zhang, Xiao-Yue Yu, Wen-Cai Zhang, Gang Li, Zhan-Ying Han, Sen Guo, Xu-Tao Zhang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Pathological cardiac hypertrophy is the primary cause of heart failure, yet its underlying mechanisms remain incompletely understood. Transmembrane protein 100 (TMEM100) plays a role in various disorders, such as nervous system disease, pain
Externí odkaz:
https://doaj.org/article/a166752f3b794a1392a154e1182a495a
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice
Autor:
Serena L’Abbate, Giuseppina Nicolini, Francesca Forini, Elisa Lepore, Sabrina Marchetti, Virginia Unfer, Gianpiero Forte, Claudia Kusmic
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117287- (2024)
This study investigates the effects of inositol (INO) supplementation on cardiac changes caused by Li in mice. The study involved 4 groups of C57BL6 mice (n=10 each): (i) mice orally administered with Li2CO3 for 8 weeks, then 4 additional weeks witho
Externí odkaz:
https://doaj.org/article/71d25b75ed3349f1a967bcb96339c7cd
Autor:
Jianjian Shi, Lei Wei
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 3, Pp 85-102 (2024)
Abstract In this study, we investigated the roles of ROCK1 in regulating structural and functional features of caveolae located at the cell membrane of cardiomyocytes, adipocytes, and mouse embryonic fibroblasts (MEFs) as well as related physiopathol
Externí odkaz:
https://doaj.org/article/5cdbc9d224c74e1b8b268a9fdc88c786
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Physiological and pathological cardiomyocyte hypertrophy are important pathophysiological processes of adult congenital heart disease-associated ventricular hypertrophy. Glutamic oxaloacetic transaminase (GOT) is a vital marker of
Externí odkaz:
https://doaj.org/article/b7d18be4182642ecaa336b2ebd947424
Autor:
Yan Zhao, Kai Wang, Chun Zhao, Ning Liu, Zhihong Wang, Wenting Yang, Zewei Cheng, Luyu Zhou, Kun Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102114- (2024)
tRNA-derived small RNAs (tsRNAs) constitute a subgroup of small noncoding RNAs (ncRNAs) originating from tRNA molecules. Their rich content, evolutionary conservatism, high stability, and widespread existence makes them significant in disease researc
Externí odkaz:
https://doaj.org/article/75dea279d8bc41f9b37c1b370807de44
Autor:
Pengpeng Li, Dongxia Qin, Tiange Chen, Wei Hou, Xinyu Song, Shumin Yin, Miaomiao Song, W.C. Hewith A. Fernando, Xiaojie Chen, Yu Sun, Juejin Wang
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background L-type Ca2+ channel CaV1.2 is essential for cardiomyocyte excitation, contraction and gene transcription in the heart, and abnormal functions of cardiac CaV1.2 channels are presented in diabetic cardiomyopathy. However, the underl
Externí odkaz:
https://doaj.org/article/469aea844fd641e99d86179f5be3e6a5
Autor:
Ryusuke Hosoda, Ryuta Nakashima, Masaki Yano, Naotoshi Iwahara, Seidai Asakura, Iyori Nojima, Yukika Saga, Risa Kunimoto, Yoshiyuki Horio, Atsushi Kuno
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 2, Pp 112-122 (2023)
Aging is associated with impairment of multiple organs, including skeletal muscle and heart. In this study, we investigated whether resveratrol, an activator of an NAD+-dependent protein deacetylase Sirtuin-1 (SIRT1), attenuates age-related sarcopeni
Externí odkaz:
https://doaj.org/article/93ecf3bf3956427989361595e6f9b9c4
Autor:
Hideaki Tagashira, Fumiha Abe, Kaori Sato-Numata, Karen Aizawa, Kei Hirasawa, Yoshinobu Kure, Daiki Iwata, Tomohiro Numata
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Cardiomyocyte hypertrophy, induced by elevated levels of angiotensin II (AngII), plays a crucial role in cardiovascular diseases. Current therapeutic approaches aim to regress cardiac hypertrophy but have limited efficacy. Widely used Japanese Kampo
Externí odkaz:
https://doaj.org/article/d52b9cc1862f4850b215ef4a08739782
Autor:
Yoichi Sunagawa, Ryosuke Tsukabe, Yudai Irokawa, Masafumi Funamoto, Yuto Suzuki, Miho Yamada, Satoshi Shimizu, Yasufumi Katanasaka, Toshihide Hamabe-Horiike, Yuto Kawase, Ryuya Naruta, Kana Shimizu, Kiyoshi Mori, Ryota Hosomi, Maki Komiyama, Koji Hasegawa, Tatsuya Morimoto
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2344 (2024)
Anserine, an imidazole dipeptide, is present in the muscles of birds and fish and has various bioactivities, such as anti-inflammatory and anti-fatigue effects. However, the effect of anserine on the development of heart failure remains unknown. We c
Externí odkaz:
https://doaj.org/article/f12b02522eb7459f8f329059436f5885
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102652- (2023)
The present study identified a novel mechanism underlying the protective effect of Sirtuin 3 (SIRT3) against pathological cardiac hypertrophy, beyond its well-accepted role as a deacetylase in mitochondria. SIRT3 modulates the peroxisomes-mitochondri
Externí odkaz:
https://doaj.org/article/9225aa10fb01493b8bee238789d6559c