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Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality

Autor: Ason C. Y. Chiang, Jan Ježek, Peiqiang Mu, Ying Di, Anna Klucnika, Martin Jabůrek, Petr Ježek, Hansong Ma

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between mitochondrial genes and their phenotypic outcome, however, has not been possible due to a lac

Externí odkaz: https://doaj.org/article/535c6d0b32ad4ccfa77fbdd9ef88c699

Cardiolipin binding enhances KcsA channel gating via both its specific and dianion-monoanion interchangeable sites

Autor: Iwamoto, Masayuki, Morito, Masayuki, Oiki, Shigetoshi, Nishitani, Yudai, Yamamoto, Daisuke, Matsumori, Nobuaki

Publikováno v: In iScience 15 December 2023 26(12)

The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats.

Autor: Allen, Mitchell E.¹, Pennington, Edward Ross^2,3, Perry, Justin B.¹, Dadoo, Sahil³, Makrecka-Kuka, Marina⁴, Dambrova, Maija⁴, Moukdar, Fatiha⁵, Patel, Hetal D.⁵, Han, Xianlin⁶, Kidd, Grahame K.^7,8, Benson, Emily K.⁸, Raisch, Tristan B.^9,10, Poelzing, Steven^9,10,11,12, Brown, David A.^1,9,13,14, Shaikh, Saame Raza³ shaikhsa@email.unc.edu

Publikováno v: Communications Biology. 7/17/2020, Vol. 3 Issue 1, p1-12. 12p.

Corrigendum to "Function-related asymmetry of the specific cardiolipin binding sites on the mitochondrial ADP/ATP carrier" [Biochim. Biophys. Acta Biomembr. 1863 (2021) 183466].

Autor: Mao X; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China; Institute of Genetics, Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China., Yao S; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China; Institute of Genetics, Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China., Yi Q; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China; Institute of Genetics, Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China., Xu ZM; Department of Urology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health and National Children's Regional Medical Center, Hangzhou, Zhejiang 310052, China., Cang X; Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China; Institute of Genetics, Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China. Electronic address: xhcang@zju.edu.cn.

Publikováno v: Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2023 Apr; Vol. 1865 (4), pp. 184140. Date of Electronic Publication: 2023 Feb 13.