Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology.

Autor: Ben Toumia I; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Bachetti T; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Chekir-Ghedira L; Unit of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine of Monastir, University of Monastir, Monastir, Tunisia., Profumo A; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Ponassi M; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Di Domizio A; SPILLOproject, Milano, Italy., Izzotti A; IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Department of Experimental Medicine, University of Genova, Genova, Italy., Sciacca S; Istituto Oncologico del Mediterraneo, Viagrande, Italy., Puglisi C; Istituto Oncologico del Mediterraneo, Viagrande, Italy., Forte S; Istituto Oncologico del Mediterraneo, Viagrande, Italy., Giuffrida R; Istituto Oncologico del Mediterraneo, Viagrande, Italy., Colarossi C; Istituto Oncologico del Mediterraneo, Viagrande, Italy., Milardi D; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Catania, Italy., Grasso G; Department of Chemical Sciences, University of Catania, Catania, Italy., Lanza V; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Catania, Italy., Fiordoro S; Department of Experimental Medicine, University of Genova, Genova, Italy., Drago G; Department of Experimental Medicine, University of Genova, Genova, Italy., Tkachenko K; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Cardinali B; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Romano P; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Iervasi E; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Vargas GC; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Barboro P; IRCCS Ospedale Policlinico San Martino, Genova, Italy., Kohnke FH; Dipartimento di Scienze Chimiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), University of Messina, Messina, Italy., Rosano C; IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jan 03; Vol. 14, pp. 1258108. Date of Electronic Publication: 2024 Jan 03 (Print Publication: 2023).

SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials.

Autor: Conte B; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.; Universitat de Barcelona, Barcelona, Spain., Boni L; S.C. Epidemiologia Clinica, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Bisagni G; Azienda unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy., Durando A; Breast Unit Ospedale S Anna, Citta' della Salute e della Scienza di Torino, Torino, Italy., Sanna G; Azienda Ospedaliera Universitaria - Sassari, Sassari, Italy., Gori S; UOC Oncologia Medica, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy., Garrone O; Breast Unit, AO S. Croce e Carle Ospedale di insegnamento, Cuneo, Italy.; Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Milano., Tamberi S; UO Oncologia, Ospedale degli Infermi, Faenza, Italy., De Placido S; Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy., Schettini F; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Spain., Pazzola A; Azienda Ospedaliera Universitaria - Sassari, Sassari, Italy., Ponzone R; Candiolo Cancer Institute, FPO-IRCCS, Gynecologic Oncology and Multidisciplinary Outpatient Oncology Clinic, Candiolo, Italy., Montemurro F; Candiolo Cancer Institute, FPO-IRCCS, Gynecologic Oncology and Multidisciplinary Outpatient Oncology Clinic, Candiolo, Italy., Lunardi G; Laboratorio Analisi Chimico-Cliniche, IRCCS-Ospedale Sacro Cuore Don Calabria, Negrar, Verona, Italy., Notaro R; Core Research Laboratory-ISPRO, Firenze, Italy., De Angioletti M; Core Research Laboratory-ISPRO, Firenze, Italy.; National Research Council (CNR) - ICCOM, Firenze, Italy., Turletti A; Breast Unit, ASL Citta' di Torino, Torino, Italy., Mansutti M; Department of Oncology, ASUFC Santa Maria della Misericordia, Udine, Italy., Puglisi F; Department of Medicine, University of Udine, Udine, Italy.; Depatment of Medical Oncology, Centro di Riferimento Oncologico di Aviano IRCCS, Aviano, Italy., Frassoldati A; Department of Morphology, Surgery and Experimental medicine, Clinical Oncology, St. Anna University Hospital, Ferrara, Italy., Porpiglia M; Breast Unit Ospedale S. Anna, AOU Città della Salute e della Scienza di Torino, Torino, Italy., Fabi A; Medical Oncology, IRCCS Regina Elena National Cancer Institute, Roma, Italy., Generali D; Medical Oncology, Azienda Istituti Ospitalieri di Cremona, Cremona, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Scognamiglio G; Oncologia Medica, Ospedale Valduce, Como, Italy., Rossi M; SOC Oncologia, ASO SS.Antonio e Biagio, Alessandria, Italy., Brasó-Maristany F; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Prat A; Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.; Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.; Reveal Genomics, Barcelona, Spain.; Institute of Oncology (IOB)-Hospital Quirónsalud, Barcelona, Spain., Cardinali B; Medical Oncology Department, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Piccioli P; Medical Oncology Department, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Serra M; Laboratory of Clinical and Experimental Immunology, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Lastraioli S; Molecular Diagnostic Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Bighin C; Medical Oncology Department 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Poggio F; Medical Oncology Department 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Lambertini M; Medical Oncology Department, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy., Del Mastro L; Medical Oncology Department, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Dec 15; Vol. 29 (24), pp. 5217-5226.

83P Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in eary high risk breast cancer: The CITUCEL trial update

Autor: Borea, R., Cardinali, B., Arecco, L., De Luca, G., Garuti, A., Mazzitelli, C., Sciutto, A., Poggio, F., Conte, B., Buzzatti, G., Blondeaux, E., Carli, F., Anselmi, G., Profumo, A., Coronel-Vargas, G.F., Ballestrero, A., Ferrando, L., Zoppoli, G., Dono, M., Del Mastro, L.

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S247-S247

Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1

Autor: Ondono R, Lirio A, Elvira C, Alvarez-Marimon E, Provenzano C, Cardinali B, Perez-Alonso M, Peralvarez-Marin A, Borrell J, Falcone G, Estrada-Tejedor R

Publikováno v: Computational and Structural Biotechnology Journal
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3' untranslated region (3'UTR). The intrinsic complexity and lack of crystallographic data makes noncoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::79b2302a756aba8a19848c966312f09f
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15393

miRNome and Proteome Profiling of Small Extracellular Vesicles Secreted by Human Glioblastoma Cell Lines and Primary Cancer Stem Cells.

Autor: Cifola I; Institute for Biomedical Technologies (ITB), CNR, 20054 Segrate, Italy., Fratini F; Proteomics Core Facility, Istituto Superiore di Sanità (ISS), 00161 Rome, Italy., Cardinali B; Institute of Biochemistry and Cell Biology (IBBC), CNR, 00015 Monterotondo, Italy., Palmieri V; Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy.; Dipartimento di Neuroscienze, Sez. Fisica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Institute for Complex Systems (ISC), CNR, 00185 Rome, Italy., Gatti G; Department of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy., Selmi T; Institute for Biomedical Technologies (ITB), CNR, 20054 Segrate, Italy., Donzelli S; Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy., Sacconi A; Clinical Trial Center, Biostatistics and Bioinformatics Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy., Cesarini V; Institute of Translational Pharmacology (IFT), CNR, 00133 Rome, Italy., Marei HE; Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35116, Egypt., Papi M; Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy.; Dipartimento di Neuroscienze, Sez. Fisica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Blandino G; Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy., Cenciarelli C; Institute of Translational Pharmacology (IFT), CNR, 00133 Rome, Italy., Falcone G; Institute of Biochemistry and Cell Biology (IBBC), CNR, 00015 Monterotondo, Italy., D'Agnano I; Institute for Biomedical Technologies (ITB), CNR, 20054 Segrate, Italy.

Publikováno v: Biomedicines [Biomedicines] 2022 Aug 04; Vol. 10 (8). Date of Electronic Publication: 2022 Aug 04.