Probabilistic analysis of tumor growth inhibition models to Support trial design.

Autor: Baaz M; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. Electronic address: Marcus.Baaz@fcc.chalmers.se., Cardilin T; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden., Lundh T; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden., Jirstrand M; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden.

Publikováno v: Journal of theoretical biology [J Theor Biol] 2024 Oct 18; Vol. 595, pp. 111969. Date of Electronic Publication: 2024 Oct 18.

Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs).

Autor: Sten S; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Cardilin T; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Chalmers Science Park, 41288, Gothenburg, Sweden., Antonsson M; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Gennemark P; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. peter.gennemark@astrazeneca.com.; Department of Biomedical Engineering, Linköping University, Linköping, Sweden. peter.gennemark@astrazeneca.com.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2023 Dec; Vol. 62 (12), pp. 1661-1672. Date of Electronic Publication: 2023 Oct 12.

Model-based assessment of combination therapies - ranking of radiosensitizing agents in oncology.

Autor: Baaz M; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden. Marcus.Baaz@fcc.chalmers.se.; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. Marcus.Baaz@fcc.chalmers.se., Cardilin T; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden., Lignet F; Translational Medicine, Quantitative Pharmacology, Merck Healthcare KGaA, Darmstadt, Germany., Zimmermann A; Translation Innovation Platform Oncology, Merck Healthcare KGaA, Darmstadt, Germany., El Bawab S; Translational Medicine, Quantitative Pharmacology, Merck Healthcare KGaA, Darmstadt, Germany.; Present Address: Translational Medicine, Servier, Suresnes, France., Gabrielsson J; Meddoor AB, Gothenburg, Sweden., Jirstrand M; Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden.

Publikováno v: BMC cancer [BMC Cancer] 2023 May 06; Vol. 23 (1), pp. 409. Date of Electronic Publication: 2023 May 06.

Exposure-response modeling improves selection of radiation and radiosensitizer combinations.

Autor: Cardilin T; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden. tim.cardilin@fcc.chalmers.se.; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. tim.cardilin@fcc.chalmers.se., Almquist J; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden.; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Jirstrand M; Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden., Zimmermann A; Translation Innovation Platform Oncology, Merck KGaA, Darmstadt, Germany., Lignet F; Translational Medicine, Merck KGaA, Darmstadt, Germany., El Bawab S; Translational Medicine, Merck KGaA, Darmstadt, Germany., Gabrielsson J; Meddoor AB, Gothenburg, Sweden.

Publikováno v: Journal of pharmacokinetics and pharmacodynamics [J Pharmacokinet Pharmacodyn] 2022 Apr; Vol. 49 (2), pp. 167-178. Date of Electronic Publication: 2021 Oct 08.

Evaluation and translation of combination therapies in oncology

Autor: Cardilin, T., Almquist, J., Jirstrand, M., Gabrielsson, J.

Quantitative techniques improve our understanding of tumor volume data for combination treatments and its translation across in vivo models and species. The focus of this paper is therefore on understanding in vivo data, highlighting key structural e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::c5ff93a51fa785f3648fe76c1f8b693a
https://publica.fraunhofer.de/handle/publica/256125