Zobrazeno 1 - 10
of 498
pro vyhledávání: '"Cardiac stem cell"'
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105125- (2024)
Summary: We review the evidence for the presence of stem/progenitor cells in the heart and the preclinical and clinical data using diverse cell types for the therapy of cardiac diseases. We highlight the failure of adult stem/progenitor cells to amel
Externí odkaz:
https://doaj.org/article/22918ee8588f4b509695396152abf216
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e18243- (2023)
Cardiomyocytes can be readily derived from human induced pluripotent stem cell (hiPSC) lines, yet its efficacy varies across different batches of the same and different hiPSC lines. To unravel the inconsistencies of in vitro cardiac differentiation,
Externí odkaz:
https://doaj.org/article/6c4aaea06da442c983f142df7412a35a
Autor:
Oualid Ayad, Zeina R. Al Sayed, Stéphane Sebille, Christophe Magaud, Charles-Albert Chapotte-Baldacci, Christophe Jayle, Jean-François Faivre, Nathalie Gaborit, Aurélien Chatelier, Patrick Bois
Publikováno v:
Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-19 (2020)
Abstract Background Human cardiac stem cells expressing the W8B2 marker (W8B2+ CSCs) were recently identified and proposed as a new model of multipotent CSCs capable of differentiating into smooth muscle cells, endothelial cells and immature myocytes
Externí odkaz:
https://doaj.org/article/2bec93225e6f46fea880072a24bf1a7a
Autor:
Han Saem Jeong, Chi-Yeon Park, Jong-Ho Kim, Hyung Joon Joo, Seung-Cheol Choi, Ji-Hyun Choi, I-Rang Lim, Jae Hyoung Park, Soon Jun Hong, Do-Sun Lim
Publikováno v:
Molecular Medicine, Vol 26, Iss 1, Pp 1-14 (2020)
Abstract Background Sca-1+ cardiac stem cells and their limited proliferative potential were major limiting factors for use in various studies. Methods Therefore, the effects of sphere genetically engineered cardiac stem cells (S-GECS) inserted with
Externí odkaz:
https://doaj.org/article/cb41ea3d840c4278b029ed41ddcfeec8
Publikováno v:
EBioMedicine, Vol 63, Iss , Pp 103193- (2021)
The BMI1 protein, a member of the PRC1 family, is a well recognised transcriptional suppressor and has the capability of maintaining the self-renewal and proliferation of tissue-specific stem cells. Numerous studies have established that BMI1 is high
Externí odkaz:
https://doaj.org/article/4b98de38ab7a4c979fd60ffb69b662b5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In the past few decades, cardiac regeneration has been the central target for restoring the injured heart. In mammals, cardiomyocytes are terminally differentiated and rarely divide during adulthood. Embryonic and fetal cardiomyocytes undergo robust
Externí odkaz:
https://doaj.org/article/a45cc702db9040b0ad6cdc8fd1bc041f
Autor:
Markus Wolfien, Denise Klatt, Amankeldi A. Salybekov, Masaaki Ii, Miki Komatsu-Horii, Ralf Gaebel, Julia Philippou-Massier, Eric Schrinner, Hiroshi Akimaru, Erika Akimaru, Robert David, Jens Garbade, Jan Gummert, Axel Haverich, Holger Hennig, Hiroto Iwasaki, Alexander Kaminski, Atsuhiko Kawamoto, Christian Klopsch, Johannes T. Kowallick, Stefan Krebs, Julia Nesteruk, Hermann Reichenspurner, Christian Ritter, Christof Stamm, Ayumi Tani-Yokoyama, Helmut Blum, Olaf Wolkenhauer, Axel Schambach, Takayuki Asahara, Gustav Steinhoff
Publikováno v:
EBioMedicine, Vol 57, Iss , Pp 102862- (2020)
Background: Bone marrow stem cell clonal dysfunction by somatic mutation is suspected to affect post-infarction myocardial regeneration after coronary bypass surgery (CABG). Methods: Transcriptome and variant expression analysis was studied in the ph
Externí odkaz:
https://doaj.org/article/dd58128840ab4b1fb0fa839501efef79
Autor:
Gustav Steinhoff, Julia Nesteruk, Markus Wolfien, Günther Kundt, Jochen Börgermann, Robert David, Jens Garbade, Jana Große, Axel Haverich, Holger Hennig, Alexander Kaminski, Joachim Lotz, Friedrich-Wilhelm Mohr, Paula Müller, Robert Oostendorp, Ulrike Ruch, Samir Sarikouch, Anna Skorska, Christof Stamm, Gudrun Tiedemann, Florian Mathias Wagner, Olaf Wolkenhauer
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 208-224 (2017)
Objective: The phase III clinical trial PERFECT was designed to assess clinical safety and efficacy of intramyocardial CD133+ bone marrow stem cell treatment combined with CABG for induction of cardiac repair. Design: Multicentre, double-blinded, ran
Externí odkaz:
https://doaj.org/article/506c8e7e8ae54a5c92e1b4df2aea82a0
Autor:
Sridharan Umapathy
Publikováno v:
Journal of the Practice of Cardiovascular Sciences, Vol 3, Iss 2, Pp 74-78 (2017)
Cardiac injury due to any cause leads to cardiac cell damage and thereby to ventricular dysfunction. Unlike current medical therapy, cardiac regeneration by stem cell therapy is a promising approach which has a potential to reverse left ventricular d
Externí odkaz:
https://doaj.org/article/911619be2d674540ab5a4ac41f22b691
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 595 (2021)
A 3-dimensional, robust, and sustained myocardial restoration by means of tissue engineering remains an experimental approach. Prolific protocols have been developed and tested in small and large animals, but, as clinical cardiac surgeons, we have no
Externí odkaz:
https://doaj.org/article/233d2d7a0fa3412095ef239b071f34e6