Patterns of Carbon-Bound Exogenous Compounds in Patients with Lung Cancer and Association with Disease Pathophysiology

Autor: Na Sun, Sabina Berezowska, Maximilian Ackermann, Michaela Aichler, Isis E. Fernandez, Ralph A. Schmid, Oliver Eickelberg, Marco Matzka, Axel Walch, Thomas Kunzke, Wim A. Wuyts, Annette Feuchtinger, Verena M. Prade, Danny Jonigk, Achim Buck

Publikováno v: Cancer research, vol. 81, no. 23, pp. 5862-5875

Asymptomatic anthracosis is the accumulation of black carbon particles in adult human lungs. It is a common occurrence, but the pathophysiologic significance of anthracosis is debatable. Using in situ high mass resolution matrix-assisted laser desorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7102791f2db44bef049fe753a08f16
https://serval.unil.ch/notice/serval:BIB_10B46795FCEE

Prognostic Significance of RAS Mutations and P53 Expression in Cutaneous Squamous Cell Carcinomas

Autor: Ana Pestana, Margarida Sá Fernandes, Manuel Campos, Sofia Macedo, Agostinho Sanches, Armando Baptista, João Vinagre, Joana Pardal, Rui Batista, José Manuel Lopes, Paula Soares

Publikováno v: Genes
Volume 11
Issue 7
Genes, Vol 11, Iss 751, p 751 (2020)

TP53 is considered the most commonly-altered gene in cutaneous squamous cell carcinoma (cSCC). Conversely, RAS mutations have been reported in a low percentage of cSCC. The objective of our study was to evaluate the frequency of p53 expression and RA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774ecc8f78c665d7549c95d89ccbcd5
https://doi.org/10.3390/genes11070751

Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry - Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort

Autor: Steven Gendreau, Martina Haberecker, Ata Tuna Ciftlik, Keith M. Kerr, Roswitha Kammler, Solange Peters, Richard Cheney, Kim Monkhorst, Karl-Friedrich Deml, Undine Rulle, Ruben Casanova, Irene Sansano, Bart Vrugt, Zoi Tsourti, Ernst-Jan M. Speel, Chengguang Wu, Rolf A. Stahel, Eric Verbeken, Antonio Marchetti, Urania Dafni, Thomas Geiger, Peter J. Wild, Walter Weder, Lukas Bubendorf, Arne Warth, Line Bille Madsen, Atilio Navarro, Panagiota Zygoura, Aleksandra Sejda, Holger Moch, Katja Schulze, Daisuke Nonaka, Erik Thunnissen, Alex Soltermann, Stephen P. Finn

Publikováno v: Journal of Thoracic Oncology, 13(12), 1851-1863. Elsevier Science
Journal of thoracic oncology, vol. 13, no. 12, pp. 1851-1863
Rulle, U, Tsourti, Z, Casanova, R, Deml, K-F, Verbeken, E, Thunnissen, E, Warth, A, Cheney, R, Sejda, A, Speel, E J, Madsen, L B, Nonaka, D, Navarro, A, Sansano, I, Marchetti, A, Finn, S P, Monkhorst, K, Kerr, K M, Haberecker, M, Wu, C, Zygoura, P, Kammler, R, Geiger, T, Gendreau, S, Schulze, K, Vrugt, B, Wild, P, Moch, H, Weder, W, Ciftlik, A T, Dafni, U, Peters, S, Bubendorf, L, Stahel, R A & Soltermann, A 2018, ' Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry — Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort ', Journal of Thoracic Oncology, vol. 13, no. 12, pp. 1851-1863 . https://doi.org/10.1016/j.jtho.2018.08.2034
Rulle, U, Tsourti, Z, Casanova, R, Deml, K F, Verbeken, E, Thunnissen, E, Warth, A, Cheney, R, Sejda, A, Speel, E J, Madsen, L B, Nonaka, D, Navarro, A, Sansano, I, Marchetti, A, Finn, S P, Monkhorst, K, Kerr, K M, Haberecker, M, Wu, C, Zygoura, P, Kammler, R, Geiger, T, Gendreau, S, Schulze, K, Vrugt, B, Wild, P, Moch, H, Weder, W, Ciftlik, A T, Dafni, U, Peters, S, Bubendorf, L, Stahel, R A & Soltermann, A 2018, ' Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry — Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort ', Journal of Thoracic Oncology, vol. 13, no. 12, pp. 1851-1863 . https://doi.org/10.1016/j.jtho.2018.08.2034
Journal of Thoracic Oncology, 13(12), 1851-1863. International Association for the Study of Lung Cancer

Introduction: Phosphatase and tensin homolog (PTEN) loss is frequently observed in NSCLC and associated with both phosphoinositide 3-kinase activation and tumoral immunosuppression. PTEN immunohistochemistry is a valuable readout, but lacks standardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb2ccb7d2d967cc5751810d904963d5
https://cris.maastrichtuniversity.nl/en/publications/7b1f4130-0c4b-476b-acd0-1c8545a2ec7a

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors

Autor: Loana Musso, Raquel T. Lima, Raffaella Cincinelli, Ana Bizarro, Michelandrea De Cesare, Sabrina Dallavalle, M. Helena Vasconcelos, Valentina Zuco, Diana Sousa

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 2, p 407 (2018)
Molecules; Volume 23; Issue 2; Pages: 407
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Background: Heat shock protein 90 (HSP90) is a well-known target for cancer therapy. In a previous work, some of us have reported a series of 3-aryl-naphtho[2,3-d]isoxazole-4,9-diones as inhibitors of HSP90. Methods: In the present work, various comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638850e929e3ec4d77bf8fdf3caa98da
http://europepmc.org/articles/PMC6017909

Turning the tide: Clinical utility of PD-L1 expression in squamous cell carcinoma of the head and neck

Autor: Astrid De Meulenaere, Sandrine Aspeslagh, Tijl Vermassen, Sylvie Rottey, Wouter Huvenne, Jo Van Dorpe, Liesbeth Ferdinande

Publikováno v: Oral oncology. 70

The use of cytotoxic and/or targeted agents is the gold standard in first- and second-line treatment of metastatic head and neck cancer. Currently the focus of oncologic research is shifting to the implementation of immune checkpoint inhibitor regime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083c5a6514cfba924362ee882afe0d82
https://pubmed.ncbi.nlm.nih.gov/28622889