Evaluation of the Novel PET Tracer [C-11]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates

Autor: van der Aart, Jasper, Yaqub, Maqsood, Kooijman, Esther J M, Bakker, Jaco, Langermans, Jan A M, Schuit, Robert C, Hofman, Mark B M, Christiaans, Johannes A M, Lammertsma, Adriaan A, Windhorst, Albert D, van Berckel, Bart N M, LAS/3’R Centre ULS

Publikováno v: Molecular Imaging and Biology, 21(4), 676-685. Springer New York
Molecular Imaging and Biology, 21(4), 676. Springer New York LLC
van der Aart, J, Yaqub, M, Kooijman, E J M, Bakker, J, Langermans, J A M, Schuit, R C, Hofman, M B M, Christiaans, J A M, Lammertsma, A A, Windhorst, A D & van Berckel, B N M 2019, ' Evaluation of the Novel PET Tracer [C-11]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates ', Molecular Imaging and Biology, vol. 21, no. 4, pp. 676-685 . https://doi.org/10.1007/s11307-018-1284-x

Purpose: There are currently no positron emission tomography (PET) radiotracers for the GluN2B (NR2B) binding sites of brain N-methyl-d-aspartate (NMDA) receptors. In rats, the GluN2B antagonist Ro25-6981 reduced the binding of N-((5-(4-fluoro-2-[11C

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