Výsledky vyhledávání - "Carbachol/ pharmacology"

Nogo-A Downregulation Improves Insulin Secretion in Mice

Autor: Patrice H. Lalive, Claire Bonal, Mahdia Benkhoucha, Caroline Pot, Martin E. Schwab, Delphine Baronnier, Pedro Luis Herrera

Publikováno v: Diabetes
Diabetes, Vol. 62, No 5 (2013) pp. 1443-52

Type 2 diabetes (T2D) is characterized by β-cell dysfunction and the subsequent depletion of insulin production, usually in a context of increased peripheral insulin resistance. T2D patients are routinely treated with oral antidiabetic agents such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04e605952a6685accbf36248b8cf857
http://europepmc.org/articles/PMC3636604

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Loss of zolpidem efficacy in the hippocampus of mice with the GABAAreceptor γ2 F77I point mutation

Autor: Elli Leppä, Peer Wulff, Waltraud Ogris, Marco Capogna, Peter Somogyi, H. Hoeger, Esa R. Korpi, Anni-Maija Linden, William Wisden, Werner Sieghart, A. Oberto, C. Halbsguth, Theofanis Karayannis, D. W. Cope, Francesco Ferraguti

Publikováno v: Cope, D W, Halbsguth, C, Karayannis, T, Wulff, P, Ferraguti, F, Hoeger, H, Leppä, E, Linden, A-M, Oberto, A, Ogris, W, Korpi, E R, Sieghart, W, Somogyi, P, Wisden, W & Capogna, M 2005, ' Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation ', The European journal of neuroscience, vol. 21, no. 11, pp. 3002-16 . https://doi.org/10.1111/j.1460-9568.2005.04127.x
Europe PubMed Central

Zolpidem is a hypnotic benzodiazepine site agonist with some gamma-aminobutyric acid (GABA)(A) receptor subtype selectivity. Here, we have tested the effects of zolpidem on the hippocampus of gamma2 subunit (gamma2F77I) point mutant mice. Analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5a0e4e690a4883f85a630b50b1ff98
https://doi.org/10.1111/j.1460-9568.2005.04127.x

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Agonist-induced down regulation of type 1 and type 3 inositol 1,4,5-tris-phosphate receptors in A7r5 and DDT1 MF-2 smooth muscle cells

Autor: Leo E. Deelman, Jan B. Parys, Robert H. Henning, Ludwig Missiaen, Henk Sipma, Humbert De Smedt, Rik Casteels, Sara Vanlingen

Publikováno v: Cell calcium, 23(1), 11-21. Churchill Livingstone

Prolonged stimulation of rat A7r5 aortic smooth muscle cells with 3 mu M vasopressin, or of hamster DDT1 MF-2 smooth muscle cells with 10 mu M bradykinin or 100 mu M histamine led within 4 h to a 40-50% down-regulation of the type 1 InsP(3) receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d4532a9602b440b1b78514cf5bd547
https://doi.org/10.1016/s0143-4160(98)90070-7

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Modulation of cholinergic nucleus basalis neurons by acetylcholine and N-methyl-d-aspartate

Autor: Patrice Fort, Mauro Serafin, Barbara E. Jones, Asaid Khateb, Michel Muhlethaler, S. Williams

Publikováno v: Neuroscience, Vol. 81, No 1 (1997) pp. 47-55
Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 1997, 81 (1), pp.47-55. ⟨10.1016/s0306-4522(97)00167-x⟩

Known to exert an important modulatory influence on the cerebral cortex, the cholinergic neurons of the basal forebrain are modulated in turn by neurotransmitters which may include acetylcholine released from processes of brainstem or forebrain neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a687319d849ff1e3d1c6a7ba6bd03374
https://doi.org/10.1016/s0306-4522(97)00167-x

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Gap junction expression and the effects of gap junction inhibitors in overactive bladder models: does ovariectomy have a role?

Autor: Babaoglu M, Zumrutbas AE, Acar IC, Hatip FB, Kucukatay V, Eskicorapci S, Aybek Z

PURPOSE: In this study, gap junction expression and the effects of estrogen deficiency and gap junction inhibitors were investigated in overactive bladder models which were created by bladder outlet obstruction. METHODS: In our study, we created four

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Rhythmic firing of medial septum non-cholinergic neurons

Autor: Patrice Fort, Mauro Serafin, Asaid Khateb, S. Williams, Michel Muhlethaler

Publikováno v: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 1996, 75 (3), pp.671-675. ⟨10.1016/0306-4522(96)00349-1⟩
Neuroscience, Vol. 75, No 3 (1996) pp. 671-675

The presence of theta rhythm (5-10 Hz) in the hippocampus has been shown to enable long-term potentiation, a synaptic mechanism which has been proposed to underlie learning and memory. Medial septum cholinergic and GABAergic neurons that project to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49285c3f0e072355a6f7c68a23adc913
https://doi.org/10.1016/0306-4522(96)00349-1

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Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues

Autor: Winzell, Maria Sörhede, Pacini, Giovanni, Wollheim, Claes, Ahrén, Bo

Publikováno v: Diabetes, Vol. 53 Suppl 3 (2004) pp. S92-6

We studied islet function in mice with beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor (HNF)-1alpha. At age 2-3 months, anesthetized transgenic and wild-type male mice underwent an intravenous glucose (1 g/kg)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c3cf11801e79e798ff7f0c2b24b51470
https://pubmed.ncbi.nlm.nih.gov/15561929

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Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion

Autor: M.T. Costa, Carmen Gonelle-Gispert, Philippe A. Halban, Karin Sadoul, Masami Takahashi

Publikováno v: Biochemical Journal, Vol. 368, No Pt 1 (2002) pp. 223-232

The tSNARE (the target-membrane soluble NSF-attachment protein receptor, where NSF is N -ethylmaleimide-sensitive fusion protein) synaptosomal-associated protein of 25 kDa (SNAP-25) is implicated in regulated insulin secretion. In pheochromocytoma PC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ca08ce3f651b771507c44b488c6c95
https://pubmed.ncbi.nlm.nih.gov/12164783

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Respective roles of carbamylcholine and cyclic adenosine monophosphate in their synergistic regulation of cell cycle in thyroid primary cultures

Autor: Van Keymeulen, Alexandra, Deleu, Sandrine, Bartek, Jiri, Dumont, Jacques Emile, Roger, Pierre P.

Publikováno v: Endocrinology, 142

The stimulation of thyroid cell proliferation by TSH through cAMP depends on permissive comitogenic factors, generally the insulin-like growth factors and insulin. In dog thyroid primary cultures, the use of the phosphodiesterase-resistant analog of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2101::272225ff74a660fbd336347497cdb958
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/38747

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Involvement of calmodulin-dependent protein kinase II in carbachol-induced rhythmic activity in the hippocampus of the rat

Autor: P. H. Boeijinga, H. W. Boddeke, Mario Raggenbass, Stefano Alberi

Publikováno v: Brain Research, Vol. 872, No 1-2 (2000) pp. 11-19
Brain Research, 872(1-2), 11-19. ELSEVIER SCIENCE BV

The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 mu M) induced synchronized field pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53d4d09e8d1f1c5ecf0b6f307aee7f6
https://pubmed.ncbi.nlm.nih.gov/10924670

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