Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Caravella Justin Andrew"'
Autor:
Jian Lin, M. Katz, S. Ashwell, A.M. Campbell, K.J. Barr, Mark T. Kershaw, Wei Lu, D. Walker, Zhongguo Wang, Angela V. Toms, L. Yao, A. Clarke, R.B. Diebold, H.R. Josephine, Deepali Gotur, A. Ericsson, Christopher J. Dinsmore, G.R. Gustafson, Caravella Justin Andrew, Jennifer Castro
Publikováno v:
Journal of Medicinal Chemistry. 63:1612-1623
Inhibition of mutant IDH1 is being evaluated clinically as a treatment option for oncology. Here we describe the structure-based design and optimization of quinoline lead compounds to identify FT-2102, a potent, orally bioavailable, brain penetrant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0965a9edfde187ce8dfcfe433ff8a562
https://doi.org/10.1021/acs.jmedchem.9b01423
https://doi.org/10.1021/acs.jmedchem.9b01423
Autor:
Weiping Wang, Adan Pinto-Fernandez, Caravella Justin Andrew, Stephanos Ioannidis, Claire Heride, Benedikt M. Kessler, David Komander, Michael J. Clague, Simon J. Davis, Marie Katz, Victoria Smith, Hannah Elcocks, Tim Hammonds, Andreas Kallinos, Sylvie Urbé, Bruce Follows, Christopher J. Dinsmore, Sunkyu Kim, Katherine J. Kayser-Bricker, Steven Mischke, Shawn Fessler, Anne Clancy, Neil P. Jones, Axel Behrens, Jonathan O'Connell, Crystal McKinnon
Publikováno v:
The Journal of Cell Biology
When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e018963cdf960a0fdc0658ee368510ab
http://europepmc.org/articles/PMC7888347
http://europepmc.org/articles/PMC7888347
Autor:
Weiping Wang, Adan Pinto-Fernandez, Simon J. Davis, Katherine J. Kayser-Bricker, Victoria Smith, Jonathan O'Connell, Christopher J. Dinsmore, Crystal McKinnon, Neil P. Jones, Bruce Follows, Marie Katz, Claire Heride, Sylvie Urbé, Anne Clancy, Benedikt M. Kessler, Andreas Kallinos, Sunkyu Kim, Axel Behrens, Steven Mischke, Stephanos Ioannidis, Shawn Fessler, David Komander, Caravella Justin Andrew, Tim Hammonds, Hannah Elcocks, Michael J. Clague
Publikováno v:
The Journal of Cell Biology
Bioxriv
Bioxriv
Clancy et al. develop a specific chemical inhibitor of USP9X and characterize its effects upon the cellular proteome. This analysis reveals a central role in the regulation of ribosomal stalling through control of critical E3 ligases.
When a rib
When a rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be84b6d5732fc90b5778aeba316a4c43
https://doi.org/10.1083/jcb.202004211
https://doi.org/10.1083/jcb.202004211
Autor:
K.J. Barr, A. Ericsson, Zhongguo Wang, David R. Lancia, A. Clarke, R.B. Diebold, S. Ashwell, George P. Luke, Deepali Gotur, Wei Lu, Jian Lin, H.R. Josephine, M. Katz, D. Walker, A.M. Campbell, Goss Stryker Kauffman, L. Yao, Angela V. Toms, Caravella Justin Andrew, H. Diep, Jennifer Castro, Kenneth W. Bair, E. Fritzen, Christopher J. Dinsmore, Stephen Hubbs, Le Wang, G.R. Gustafson, Tatiana E. Shelekhin, Mark T. Kershaw
Publikováno v:
Journal of medicinal chemistry. 62(14)
Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers. Inhibition of mutant IDH1 (mIDH1) with small molecules has been clinically validated as a promising therapeutic treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74eee5a37b35c08111cdd42f3f0e0830
https://pubmed.ncbi.nlm.nih.gov/31199148
https://pubmed.ncbi.nlm.nih.gov/31199148
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2002.
Includes bibliographical references (p. 189-205).
This electronic version was submitted by the student author. The certified thesis is available in the Instit
Includes bibliographical references (p. 189-205).
This electronic version was submitted by the student author. The certified thesis is available in the Instit
Externí odkaz:
http://hdl.handle.net/1721.1/16823
