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The deubiquitylase USP9X controls ribosomal stalling.

Autor: Clancy A; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Heride C; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, UK., Pinto-Fernández A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Elcocks H; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kallinos A; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kayser-Bricker KJ; FORMA Therapeutics, Watertown, MA., Wang W; FORMA Therapeutics, Watertown, MA., Smith V; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Davis S; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Fessler S; FORMA Therapeutics, Watertown, MA., McKinnon C; FORMA Therapeutics, Watertown, MA., Katz M; FORMA Therapeutics, Watertown, MA., Hammonds T; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, UK., Jones NP; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, UK., O'Connell J; FORMA Therapeutics, Watertown, MA., Follows B; FORMA Therapeutics, Watertown, MA., Mischke S; FORMA Therapeutics, Watertown, MA., Caravella JA; FORMA Therapeutics, Watertown, MA., Ioannidis S; FORMA Therapeutics, Watertown, MA., Dinsmore C; FORMA Therapeutics, Watertown, MA., Kim S; FORMA Therapeutics, Watertown, MA., Behrens A; Adult Stem Cell Laboratory, Francis Crick Institute, London, UK., Komander D; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Kessler BM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Urbé S; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Clague MJ; Department of Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Publikováno v: The Journal of cell biology [J Cell Biol] 2021 Mar 01; Vol. 220 (3).

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.

Autor: Lin J; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Lu W; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Caravella JA; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Campbell AM; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Diebold RB; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Ericsson A; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Fritzen E; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Gustafson GR; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Lancia DR Jr; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Shelekhin T; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Wang Z; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Castro J; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Clarke A; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Gotur D; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Josephine HR; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Katz M; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Diep H; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Kershaw M; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Yao L; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Kauffman G; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Hubbs SE; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Luke GP; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Toms AV; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Wang L; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Bair KW; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Barr KJ; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Dinsmore C; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Walker D; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States., Ashwell S; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Jul 25; Vol. 62 (14), pp. 6575-6596. Date of Electronic Publication: 2019 Jul 08.