Current status of immunological therapies for rheumatoid arthritis with a focus on antigen-specific therapeutic vaccines.

Autor: Zimmerman DH; CEL-SCI Corporation, Vienna, VA, United States., Szekanecz Z; Department of Rheumatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Markovics A; Department of Orthopedic Surgery and Department of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, United States., Rosenthal KS; Department of Basic Sciences, Augusta University/University of Georgia Medical Partnership, Athens, GA, United States., Carambula RE; CEL-SCI Corporation, Vienna, VA, United States., Mikecz K; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Mar 06; Vol. 15, pp. 1334281. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).

Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis.

Autor: Zimmerman DH; CEL-SCI Corporation, 8229 Boone Blvd, Vienna, VA 22182, USA., Mikecz K; Department of Orthopedic Surgery, Rush University Medical Center, 1735 W. Harrison St, Chicago, IL 60612, USA., Markovics A; Department of Orthopedic Surgery, Rush University Medical Center, 1735 W. Harrison St, Chicago, IL 60612, USA., Carambula RE; CEL-SCI Corporation, 8229 Boone Blvd, Vienna, VA 22182, USA., Ciemielewski JC; CEL-SCI Corporation, 8229 Boone Blvd, Vienna, VA 22182, USA., Toth DM; Department of Orthopedic Surgery, Rush University Medical Center, 1735 W. Harrison St, Chicago, IL 60612, USA.; Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, 1468 Madison Ave, New York, NY 10029, USA., Glant TT; Department of Orthopedic Surgery, Rush University Medical Center, 1735 W. Harrison St, Chicago, IL 60612, USA., Rosenthal KS; Department of Basic Medical Sciences, Augusta University/University of Georgia Medical Partnership, 1425 Prince Avenue, Athens, GA 30602, USA.

Publikováno v: Vaccines [Vaccines (Basel)] 2021 May 02; Vol. 9 (5). Date of Electronic Publication: 2021 May 02.

An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.

Autor: Mikecz K; Rush University Medical Center, Department of Orthopedic Surgery, 1735 W. Harrison St., Cohn Research Building, Chicago, IL 60612, United States. Electronic address: Katalin_Mikecz@rush.edu., Glant TT; Rush University Medical Center, Department of Orthopedic Surgery, 1735 W. Harrison St., Cohn Research Building, Chicago, IL 60612, United States. Electronic address: Tibor_Glant@rush.edu., Markovics A; Rush University Medical Center, Department of Orthopedic Surgery, 1735 W. Harrison St., Cohn Research Building, Chicago, IL 60612, United States. Electronic address: Adrienn_Markovics@rush.edu., Rosenthal KS; Roseman University of Health Sciences College of Medicine, 10530 Discovery Dr., Las Vegas, NV 89135, United States. Electronic address: krosenthal@roseman.edu., Kurko J; Rush University Medical Center, Department of Orthopedic Surgery, 1735 W. Harrison St., Cohn Research Building, Chicago, IL 60612, United States. Electronic address: kurkojulcsi@gmail.com., Carambula RE; CEL-SCI Corporation, 8229 Boone Blvd., Suite 802, Vienna, VA 22182, United States. Electronic address: rcarambula@cel-sci.com., Cress S; CEL-SCI Corporation, 8229 Boone Blvd., Suite 802, Vienna, VA 22182, United States. Electronic address: scress@cel-sci.com., Steiner HL Rd; CEL-SCI Corporation, 8229 Boone Blvd., Suite 802, Vienna, VA 22182, United States. Electronic address: hstein3@gmail.com., Zimmerman DH; CEL-SCI Corporation, 8229 Boone Blvd., Suite 802, Vienna, VA 22182, United States. Electronic address: dzimmerman@cel-sci.com.

Publikováno v: Vaccine [Vaccine] 2017 Jul 13; Vol. 35 (32), pp. 4048-4056. Date of Electronic Publication: 2017 Jun 03.