Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cara K Fraser"'
Autor:
Natalie E Stevens, Cara K Fraser, Mohammed Alsharifi, Michael P Brown, Kerrilyn R Diener, John D Hayball
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68895 (2013)
Passive immunotherapies utilising polyclonal antibodies could have a valuable role in preventing and treating infectious diseases such as influenza, particularly in pandemic situations but also in immunocompromised populations such as the elderly, th
Externí odkaz:
https://doaj.org/article/f57c6ebaae0d4f3ea32cdc726b166c2a
Autor:
Lingzhi Ren, Li Zhong, Miguel Sena-Esteves, Jia Li, Dan Wang, Ran He, Mengxin Li, Cara K. Fraser, Richard P. Moser, Terence R. Flotte, Tim Kuchel, Karen Tran, Jun Xie, Guangping Gao, Neil Aronin
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss, Pp 65-72 (2018)
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss, Pp 65-72 (2018)
Pre-existing neutralizing antibody (NAb) against adeno-associated virus (AAV) commonly found in primates is a major host barrier that can severely compromise in vivo gene transfer by AAV vectors. To achieve proof-of-concept success in clinical develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7a83d475a6e3f10559e66c4d1d7dba
http://europepmc.org/articles/PMC6205343
http://europepmc.org/articles/PMC6205343
Autor:
Natalie E. Stevens, Cara K. Fraser, John D. Hayball, Kerrilyn R. Diener, Tim Kuchel, Marianne J. Chapman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Sepsis remains a significant health burden and a major clinical need exists for therapeutics to dampen the excessive and uncontrolled immune activation. Nuclear protein high mobility group box protein 1 (HMGB1) is released following cell death and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7715df618c2a494624924e31846c3939
https://doaj.org/article/db850342f341408eaced7e104b682ab6
https://doaj.org/article/db850342f341408eaced7e104b682ab6
Autor:
Natalie E. Stevens, Cara K. Fraser, John D. Hayball, Marianne J. Chapman, Kerrilyn R. Diener, Matthew J Maiden, Coralie H. Nash, Tim Kuchel
Publikováno v:
Experimental and Therapeutic Medicine
Sepsis is a highly complex and often fatal syndrome which varies widely in its clinical manifestations, and therapies that target the underlying uncontrolled immune status in sepsis are needed. The failure of preclinical approaches to provide signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a9ce82b24879dd1b6300f9d9e0fffa
https://doi.org/10.3892/etm.2019.7961
https://doi.org/10.3892/etm.2019.7961
Autor:
Sunthara Rajan Perumal, Timothy R. Kuchel, Adam B. O’Connell, Brendan Sinnott, A. Jennifer Morton, Cara K. Fraser, Kim M. Hemsley
Publikováno v:
Journal of Neurology and Experimental Neuroscience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8e23b5eca69654d4f60ae96f62f272
https://doi.org/10.17756/jnen.2019-054
https://doi.org/10.17756/jnen.2019-054
Autor:
Edith L. Pfister, Tim Kuchel, Lori A. Kennington, Florie Borel, Natalie DiNardo, Ellen Sapp, Faith Conroy, Marian DiFiglia, Xin Han, Gwladys Gernoux, A. Jennifer Morton, Miguel Sena-Esteves, Richard P. Moser, Neil Aronin, Danjing Hu, David Howland, Erica Mondo, Suzanne J. Reid, Guangping Gao, Emily S. Johnson, Christian Mueller, Pengpeng Liu, Cara K. Fraser, Petr Vodicka
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant HTT, but evidence for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0559c7eac6c260f5911cac3ddf9011
Autor:
Sinoula Apostolou, Mohammed Alnakhli, Cara K. Fraser, Wing Yin Tong, Tim Kuchel, Sougata Sinha, Nicolas H. Voelcker, Richa Bhardwaj, Bryone J. Kuss
Publikováno v:
Journal of Nanobiotechnology
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-17 (2018)
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-17 (2018)
Background Multidrug resistance-associated protein 1 (MRP1) overexpression plays a major role in chemoresistance in glioblastoma multiforme (GBM) contributing to its notorious deadly nature. Although MRP1-siRNA transfection to GBM in vitro has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e112422a811e4f4c8a5dc478a7dca87
https://pubmed.ncbi.nlm.nih.gov/29653579
https://pubmed.ncbi.nlm.nih.gov/29653579
Autor:
Debra J, Skene, Benita, Middleton, Cara K, Fraser, Jeroen L A, Pennings, Timothy R, Kuchel, Skye R, Rudiger, C Simon, Bawden, A Jennifer, Morton
Publikováno v:
Scientific Reports
The pronounced cachexia (unexplained wasting) seen in Huntington’s disease (HD) patients suggests that metabolic dysregulation plays a role in HD pathogenesis, although evidence of metabolic abnormalities in HD patients is inconsistent. We performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aebf27dcd32345d77b547a59fdd04115
https://pubmed.ncbi.nlm.nih.gov/28223686
https://pubmed.ncbi.nlm.nih.gov/28223686
Autor:
John D. Hayball, Kerrilyn R. Diener, Cara K. Fraser, Natalie E. Stevens, Antoinette Hatjopolous, Mohammed Alsharifi
Publikováno v:
Scientific Reports
Passive immunotherapy may have particular benefits for the treatment of severe influenza infection in at-risk populations, however little is known of the impact of passive immunotherapy on the formation of memory responses to the virus. Ideally, pass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9c20c0416bad0228a0751051ca50fd
https://doi.org/10.1038/srep29154
https://doi.org/10.1038/srep29154
Autor:
Leigh R. Guerin, Kerrilyn R. Diener, Timothy P. Hughes, John D. Hayball, Erin L. Lousberg, Cara K. Fraser, Michael P. Brown
Publikováno v:
Cancer Biology & Therapy. 10:715-727
The Src/Abl tyrosine kinase inhibitor dasatinib is an approved chronic myeloid leukemia treatment and is under investigation for solid tumor therapy. Members of the Src family of kinases (SFKs) are involved in the process of metastasis and dasatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026260c9900eae5e4bd9911dfbc1c924
https://doi.org/10.4161/cbt.10.7.12926
https://doi.org/10.4161/cbt.10.7.12926