Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Cara I. D'Amico"'
Autor:
Cara I. D’Amico, Gillian Robbins, Iris Po, Zhichao Fang, Thomas R. Slaney, Gabi Tremml, Li Tao, Brandon T. Ruotolo, Robert T. Kennedy
Publikováno v:
Journal of the American Society for Mass Spectrometry.
Publikováno v:
Analytical chemistry. 94(38)
Native mass spectrometry coupled to ion mobility (IM-MS) has become an important tool for the investigation of protein structure and dynamics upon ligand binding. Additionally, collisional activation or collision induced unfolding (CIU) can further p
Publikováno v:
Anal Bioanal Chem
Electrophoresis has demonstrated utility as tool for screening of small molecule modulators of protein-protein interactions and enzyme targets. Screening of large chemical libraries requires high-throughput separations. Such fast separation can be ac
Publikováno v:
Expert Opinion on Drug Discovery. 12:213-224
Many screening platforms are prone to assay interferences that can be avoided by directly measuring the target or enzymatic product. Capillary electrophoresis (CE) and microchip electrophoresis (MCE) have been applied in a variety of formats to drug