Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Cara E Ellis"'
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Sandra Pereira, Daemon L. Cline, Melissa Chan, Kalin Chai, Ji Soo Yoon, Shannon M. O’Dwyer, Cara E. Ellis, Maria M. Glavas, Travis D. Webber, Robert K. Baker, Suheda Erener, Scott D. Covey, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodolog
Externí odkaz:
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
Autor:
Andraž Stožer, Marko Šterk, Eva Paradiž Leitgeb, Rene Markovič, Maša Skelin Klemen, Cara E. Ellis, Lidija Križančić Bombek, Jurij Dolenšek, Patrick E. MacDonald, Marko Gosak
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Islets of Langerhans are multicellular microorgans located in the pancreas that play a central role in whole-body energy homeostasis. Through secretion of insulin and other hormones they regulate postprandial storage and interprandial usage of energy
Externí odkaz:
https://doaj.org/article/109af4155a4f429eb54fcff8d94f2722
Autor:
Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O’Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blüher, Hana Algül, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100434- (2021)
Summary: miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of mi
Externí odkaz:
https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f
Autor:
Eva Tudurí, Maria M. Glavas, Ali Asadi, Robert K. Baker, Cara E. Ellis, Galina Soukhatcheva, Marjolaine Philit, Frank K. Huynh, James D. Johnson, C. Bruce Verchere, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract The study of primary glucagon-secreting α-cells is hampered by their low abundance and scattered distribution in rodent pancreatic islets. We have designed a double-stranded adeno-associated virus containing a rat proglucagon promoter (700
Externí odkaz:
https://doaj.org/article/556a5308d1314702b2cd07d70fc68443
Autor:
Nelly Saber, Cara E. Ellis, Diepiriye G. Iworima, Robert K. Baker, Alireza Rezania, Timothy J. Kieffer
Publikováno v:
Diabetes. 72:590-598
Few studies have examined the differentiation of human embryonic stem cell (hESC)–derived pancreatic endoderm cells (PECs) in different implantation sites. Here, we investigate the influence of implantation site and recipient sex on the differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8238abb614ae5175280da21c59ca231
https://doi.org/10.2337/db22-0692
https://doi.org/10.2337/db22-0692
Autor:
Evgeniy Panzhinskiy, Haoning Cen, Timothy J. Kieffer, Mark O. Huising, Søs Skovsø, James D. Johnson, Xiaoke Hu, Honey Modi, Derek A. Dionne, Yiwei Bernie Zhao, Shouhong Xuan, Nicole A.J. Krentz, Nilou Noursadeghi, Cara E. Ellis, Francis C. Lynn, Yi Han Xia, Chieh Min Jamie Chu
Publikováno v:
Diabetes. 71:2612-2631
Heterogeneity within specific cell types is common and increasingly apparent with the advent of single cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β cells of the endocrine pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19737edc4653abebba9d8b9c474aa419
https://doi.org/10.2337/db21-1065
https://doi.org/10.2337/db21-1065
Autor:
Melissa Chan, Shannon O'Dwyer, Kalin Chai, Sandra Pereira, Suheda Erener, Daemon L. Cline, Timothy J. Kieffer, Travis D. Webber, Scott D. Covey, Robert K. Baker, Cara E. Ellis, Maria M. Glavas, Ji Soo Yoon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodology to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48f93a5f68f04908f43db82628bb63b
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
Insulin-dependent diabetes affects millions of people worldwide and results in significant burdens to both patients and healthcare systems. Islet transplantation provides superior glycaemic control compared to the standard therapy of injectable insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7324ee885adf079c562e3ed739e5f2e2
https://doi.org/10.1093/med/9780198870197.003.0263
https://doi.org/10.1093/med/9780198870197.003.0263
Autor:
Travis D. Webber, Susanne M. Clee, Robert K. Baker, Cara E. Ellis, Majid Mojibian, Timothy J. Kieffer, Scott D. Covey, Shannon O'Dwyer, Victor So, Ji Soo Yoon, Sandra Pereira, Subashini Karunakaran, Maria M. Glavas
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
The relative contribution of peripheral and central leptin signalling to the regulation of metabolism and the mechanisms through which leptin affects glucose homeostasis have not been fully elucidated. We generated complementary lines of mice with ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4cb60123d29816776e2d5b3b70c6f0
http://link.springer.com/article/10.1038/s41598-019-39498-3
http://link.springer.com/article/10.1038/s41598-019-39498-3