Výsledky vyhledávání - "Cara E, Brocklehurst"

Akademický článek

Integrated and automated high-throughput purification of libraries on microscale

Autor: Carol Ginsburg-Moraff, Jonathan Grob, Karl Chin, Grant Eastman, Sandra Wildhaber, Mark Bayliss, Heinrich M. Mues, Marco Palmieri, Jennifer Poirier, Marcel Reck, Alexandre Luneau, Stephane Rodde, John Reilly, Trixie Wagner, Cara E. Brocklehurst, René Wyler, David Dunstan, Alexander N. Marziale, PhD

Publikováno v: SLAS Technology, Vol 27, Iss 6, Pp 350-360 (2022)

We herein report the development of an automation platform for rapid purification and quantification of chemical libraries including reformatting of chemical matter to 10 mM DMSO stock solutions. This fully integrated workflow features tailored condi

Externí odkaz: https://doaj.org/article/6cfbd53782af4137b65faab4d0442ce7

Zobrazit plný text záznamu

Akademický článek

Fostering Research Synergies between Chemists in Swiss Academia and at Novartis

Autor: Arndt Meyer, Daniel Baeschlin, Cara E. Brocklehurst, Myriam Duckely, Fabrice Gallou, Lucie E. Lovelle, Michael Parmentier, Thierry Schlama, Radka Snajdrova, Yves P. Auberson

Publikováno v: CHIMIA, Vol 75, Iss 11, Pp 936-942 (2021)

We present a short overview of the way Novartis chemists interact and collaborate with the academic chemistry community in Switzerland. This article exemplifies a number of collaborations, and illustrates opportunities to foster research synergies be

Externí odkaz: https://doaj.org/article/0be771cd20a34e51afe795c8508edda4

Zobrazit plný text záznamu

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors

Publikováno v: ChemMedChem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87689f9fe496e8ff4e8b8008d72b261f
https://doi.org/10.1002/cmdc.202300051

Zobrazit plný text záznamu

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Publikováno v: Journal of Medicinal Chemistry. 64:7241-7260

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795fc619db3aa5e70b7fe14aeddd53fe
https://doi.org/10.1021/acs.jmedchem.1c00343

Zobrazit plný text záznamu

Selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold. A new potential non-classical isostere of indole and a precursor of push–pull dyes

Autor: Fabio Lima, Thomas Bein, Derya Bessinger, Cara E. Brocklehurst, Saroj K. Rout, Konstantin Karaghiosoff, Kuno Schwärzer, Paul Knochel

Publikováno v: Chemical Science. 12:12993-13000

We report the selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold using a Br/Mg-exchange, as well as regioselective magnesiations and zincations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl), followed by trapping reactions wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6523bfe9d83798490e49eb930c2ab64c
https://doi.org/10.1039/d1sc04155j

Zobrazit plný text záznamu

Building bridges

Autor: Cara E. Brocklehurst, Edward A. Anderson

Publikováno v: Nature Chemistry. 13:928-930

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f519516ed2b962af35ac55ac0e1d0b8
https://doi.org/10.1038/s41557-021-00784-1

Zobrazit plný text záznamu

Reliable Functionalization of 5,6-Fused Bicyclic N-Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics

Autor: Saroj Kumar Rout, Agonist Kastrati, Harish Jangra, Kuno Schwärzer, Alisa S. Sunagatullina, Maximilien Garny, Fabio Lima, Cara E. Brocklehurst, Konstantin Karaghiosoff, Hendrik Zipse, Paul Knochel

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 28(33)

DFT-calculations allow prediction of the reactivity of uncommon N-heterocyclic scaffolds of pyrazolo[1,5-a]pyrimidines and imidazo[1,2-b]pyridazines and considerably facilitate their functionalization. The derivatization of these N-heterocycles was r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17502ebaf2a5a9c99e54f24bde664baa
https://pubmed.ncbi.nlm.nih.gov/35384103

Zobrazit plný text záznamu

Plný text ve formátu HTML