Výsledky vyhledávání - "Cara C. Schafer"

Supplementary Figures 1 - 7 from Enhancement of Antitumor Immunity in Lung Cancer by Targeting Myeloid-Derived Suppressor Cell Pathways

Autor: Jessy S. Deshane, Selvarangan Ponnazhagan, Stefan C. Grant, Victor J. Thannickal, Gene P. Siegal, Zhihuan Sun, Justin Roth, Hubert M. Tse, Jaroslaw Zmijewski, Tong Huan Jin, Cara C. Schafer, Anandi Sawant

PDF file - 381K, The phenotype of MDSC in the lung and spleen from lung cancer challenged mice (S1); Reduced tumor burden in mice from Gem and SODmim+Gem therapy groups (S2); Combination therapy reduced infiltration of neutrophils but not macrophages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c17d4842087ff567b7d8feeb296532c
https://doi.org/10.1158/0008-5472.22399442

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Abstract 3805: Immunologic transcript and cell type evaluation of prostate tumors from a military cohort of African American and Caucasian American patients

Autor: Cara C. Schafer, Jiji Jiang, Sally Elsamanoudi, Darryl Nousome, Denise Young, Yingjie Song, Isabell Sesterhenn, Gregory Chesnut, Shyh-Han Tan

Publikováno v: Cancer Research. 82:3805-3805

Background: Health and racial disparities in prostate cancer place African American (AA) men at greater risk of developing and having a poorer outcome from the disease, especially at a younger age compared to Caucasian American (CA) men. This inciden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9591485ebd3b29f5caa84de475799c38
https://doi.org/10.1158/1538-7445.am2022-3805

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Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5

Autor: Steven R. Duncan, Cara C. Schafer, Selvarangan Ponnazhagan, Sultan Tousif, Hui-Chen Hsu, John F. Kearney, Jessy S. Deshane, Kenneth P. Hough, Yong Wang

Publikováno v: The Journal of Immunology. 201:278-295

Myeloid-derived suppressor cells (MDSCs) are known suppressors of antitumor immunity, affecting amino acid metabolism and T cell function in the tumor microenvironment. However, it is unknown whether MDSCs regulate B cell responses during tumor progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70c6ff0bce555ce12572622dcaf5d38
https://doi.org/10.4049/jimmunol.1701069

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Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

Autor: Victor J. Thannickal, Stefan C. Grant, Cara C. Schafer, Yong Wang, Selvarangan Ponnazhagan, Jessy S. Deshane, Kenneth P. Hough, Anandi Sawant, Jaroslaw W. Zmijewski

Publikováno v: Oncotarget

// Cara C. Schafer 1 , Yong Wang 1 , Kenneth P. Hough 1 , Anandi Sawant 2 , Stefan C. Grant 1 , Victor J. Thannickal 1 , Jaroslaw Zmijewski 1 , Selvarangan Ponnazhagan 2 , Jessy S. Deshane 1 1 Department of Medicine, University of Alabama at Birmingh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059c52fbc5b5a0b5d0a12bdc41d73121
https://doi.org/10.18632/oncotarget.12249

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ERK/MAPK regulates ERRγ expression, transcriptional activity, and receptor-mediated Tamoxifen resistance in ER+ breast cancer

Autor: Mary M. Heckler, Rebecca B. Riggins, Hemang Thakor, Cara C. Schafer

Selective estrogen receptor modulators such as tamoxifen (TAM) significantly improve breast cancer-specific survival for women with estrogen receptor-positive (ER+) disease. However, resistance to TAM remains a major clinical problem. The resistant p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc16ad067b86963c197c84e3916f7ef
https://europepmc.org/articles/PMC4079056/

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Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways

Autor: Hubert M. Tse, Jessy S. Deshane, Tong Huan Jin, Cara C. Schafer, Zhihuan Sun, Selvarangan Ponnazhagan, Jaroslaw W. Zmijewski, Stefan C. Grant, Justin C. Roth, Gene P. Siegal, Anandi Sawant, Victor J. Thannickal

Chemoresistance due to heterogeneity of the tumor microenvironment (TME) hampers the long-term efficacy of first-line therapies for lung cancer. Current combination therapies for lung cancer provide only modest improvement in survival, implicating ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a546b4b5281c4b7a0ab422ee184cd8
https://europepmc.org/articles/PMC3854493/

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Modulation of indoleamine 2,3‐dioxygenase pathway by a combination therapy strategy targeting myeloid derived suppressor cell function in lung cancer

Autor: Justin C. Roth, Stefan C. Grant, Cara C. Schafer, Selvarangan Ponnazhagan, Tong Huan Jin, Jessy S. Deshane, Anandi Sawant

Publikováno v: The FASEB Journal. 27

Immunosuppression in the tumor microenvironment (TME) has dampened the efficacy of current front line combination chemotherapies for lung cancer thus providing limited improvement in patient surviv...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3edc3db8cec8bdee03757fe95dfee6af
https://doi.org/10.1096/fasebj.27.1_supplement.1105.25

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Abstract 634: Combination chemotherapy significantly reduces indoleamine 2,3-dioxygenase activity in NSCLC patients

Autor: Tong Huan Jin, Anandi Sawant, Yong Wang, Stefan C. Grant, Cara C. Schafer, Selvarangan Ponnazhagan, Jessy S. Deshane

Publikováno v: Cancer Research. 74:634-634

Heterogeneity and immunosuppression in the tumor microenvironment (TME) has dampened the efficacy of current frontline combination chemotherapies for lung cancer which has provided limited improvement in patient survival. Modified amino acid metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fe0e8121aa4af00072ef3dee6ed7abe
https://doi.org/10.1158/1538-7445.am2014-634

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