Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cara, Adolph"'
Autor:
Kiel Hards, Chen-Yi Cheung, Natalie Waller, Cara Adolph, Laura Keighley, Zhi Shean Tee, Liam K. Harold, Ayana Menorca, Richard S. Bujaroski, Benjamin J. Buckley, Joel D. A. Tyndall, Matthew B. McNeil, Kyu Y. Rhee, Helen K. Opel-Reading, Kurt Krause, Laura Preiss, Julian D. Langer, Thomas Meier, Erik J. Hasenoehrl, Michael Berney, Michael J. Kelso, Gregory M. Cook
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Derivatives of the FDA-approved drug, amiloride, can eliminate drug-resistant Mycobacterium tuberculosis in vitro by interfering with bacterial energy conservation.
Externí odkaz:
https://doaj.org/article/dae3bf53428948ca8c7fbb2eb80c8d45
Autor:
Matthew B. McNeil, Chen-Yi Cheung, Natalie J. E. Waller, Cara Adolph, Cassandra L. Chapman, Noon E. J. Seeto, William Jowsey, Zhengqiu Li, H. M. Adnan Hameed, Tianyu Zhang, Gregory M. Cook
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Mycobacterium tuberculosis remains a leading cause of infectious disease morbidity and mortality for which new drug combination therapies are needed. Mycobacterial bioenergetics has emerged as a promising space for the development of novel therapeuti
Externí odkaz:
https://doaj.org/article/ee0242a3a0bb4732ac464a6c58aeb610
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Succinate is a major focal point in mycobacterial metabolism and respiration, serving as both an intermediate of the tricarboxylic acid (TCA) cycle and a direct electron donor for the respiratory chain. Mycobacterium tuberculosis encodes mul
Externí odkaz:
https://doaj.org/article/0b5fb11e39254fe88d6f611e2433c8ec
Autor:
Kiel, Hards, Chen-Yi, Cheung, Natalie, Waller, Cara, Adolph, Laura, Keighley, Zhi Shean, Tee, Liam K, Harold, Ayana, Menorca, Richard S, Bujaroski, Benjamin J, Buckley, Joel D A, Tyndall, Matthew B, McNeil, Kyu Y, Rhee, Helen K, Opel-Reading, Kurt, Krause, Laura, Preiss, Julian D, Langer, Thomas, Meier, Erik J, Hasenoehrl, Michael, Berney, Michael J, Kelso, Gregory M, Cook
Publikováno v:
Communications biology. 5(1)
Increasing antimicrobial resistance compels the search for next-generation inhibitors with differing or multiple molecular targets. In this regard, energy conservation in Mycobacterium tuberculosis has been clinically validated as a promising new dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27d4818343c40ab81f2a54807685303c
https://pubmed.ncbi.nlm.nih.gov/35210534
https://pubmed.ncbi.nlm.nih.gov/35210534
Autor:
Gregory M. Cook, Liam K. Harold, Kiel Hards, Matthew B. McNeil, Adrian Jinich, Kyu Y. Rhee, Cara Adolph, Chen-Yi Cheung
Publikováno v:
Progress in biophysics and molecular biology. 152
Cellular bioenergetics is an area showing promise for the development of new antimicrobials, antimalarials and cancer therapy. Enzymes involved in central carbon metabolism and energy generation are essential mediators of bacterial physiology, persis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057830c318694be031a8d06b80514862
https://pubmed.ncbi.nlm.nih.gov/31733221
https://pubmed.ncbi.nlm.nih.gov/31733221