Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Capucine L. Grandjean"'
Publikováno v:
Cell Reports, Vol 19, Iss 12, Pp 2469-2476 (2017)
Summary: Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages
Externí odkaz:
https://doaj.org/article/5de5b18478854e8dbe5579a70db71df6
Autor:
Morgane Boulch, Marine Cazaux, Alexis Cuffel, Marion V. Guerin, Zacarias Garcia, Ruby Alonso, Fabrice Lemaître, Alexander Beer, Béatrice Corre, Laurie Menger, Capucine L. Grandjean, Florence Morin, Catherine Thieblemont, Sophie Caillat-Zucman, Philippe Bousso
Publikováno v:
Nature Cancer
Nature Cancer, 2023, ⟨10.1038/s43018-023-00570-7⟩
Nature Cancer, 2023, ⟨10.1038/s43018-023-00570-7⟩
CD4+ T cells and CD4+ chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the mechanisms dictating how and when CD4+ T cells promote tumor regression are incompletely unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8211ffd4eb62019b8b82a7a399412
https://hal-pasteur.archives-ouvertes.fr/pasteur-04158305
https://hal-pasteur.archives-ouvertes.fr/pasteur-04158305
Autor:
Yann Loe-Mie, Philippe Bousso, Marine Cazaux, Zacarias Garcia, Fabrice Lemaître, Béatrice Corre, Capucine L. Grandjean, Ronan Thibaut, Morgane Boulch
Publikováno v:
Science Immunology
Science Immunology, 2021, 6 (57), pp.eabd4344. ⟨10.1126/sciimmunol.abd4344⟩
Science Immunology, American Association for the Advancement of Science, 2021, 6 (57), pp.eabd4344. ⟨10.1126/sciimmunol.abd4344⟩
Science Immunology, 2021, 6 (57), pp.eabd4344. ⟨10.1126/sciimmunol.abd4344⟩
Science Immunology, American Association for the Advancement of Science, 2021, 6 (57), pp.eabd4344. ⟨10.1126/sciimmunol.abd4344⟩
International audience; Chimeric antigen receptor (CAR) T cell therapy relies on the activity of a large pool of tumor-targeting cytotoxic effectors. Whether CAR T cells act autonomously or require interactions with the tumor microenvironment (TME) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a3dcbad45018fd088202411a33008c
https://hal-pasteur.archives-ouvertes.fr/pasteur-03266252/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03266252/document
Anti-CD20 monoclonal antibody (mAb) represents an effective strategy for the treatment of B cell malignancies that may involve complement activity, antibody dependent cellular cytotoxicity (ADCC) and phagocytosis (ADP). While ADP mediated by Kupffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc441aaad6d05c02da8f9bdfc0f1d3dd
https://doi.org/10.1101/2020.05.26.116806
https://doi.org/10.1101/2020.05.26.116806
Publikováno v:
Trends in Immunology
Trends in Immunology, 2019, 40 (11), pp.1022-1034. ⟨10.1016/j.it.2019.09.002⟩
Trends in Immunology, Elsevier, 2019, 40 (11), pp.1022-1034. ⟨10.1016/j.it.2019.09.002⟩
Trends in Immunology, 2019, 40 (11), pp.1022-1034. ⟨10.1016/j.it.2019.09.002⟩
Trends in Immunology, Elsevier, 2019, 40 (11), pp.1022-1034. ⟨10.1016/j.it.2019.09.002⟩
International audience; Understanding complex interactions between the immune system and the tumor microenvironment is an essential step towards the rational development and optimization of immunotherapies. Several experimental approaches are availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75743cdf4d27917f9130917adc3a92c
https://hal-pasteur.archives-ouvertes.fr/pasteur-02944694/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02944694/document
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
CD4(+)CD8(+) “double positive” (DP) thymocytes differentiate into diverse αβ T cell sub-types using mechanistically distinct programs. For example, conventional αβ T cells develop from DP cells after partial-agonist T cell receptor (TCR) inte
Autor:
Philippe Bousso, Richard J Beck, Idan Milo, Joost B. Beltman, Capucine L. Grandjean, Jérémy Postat, Fabrice Lemaître, Zacarias Garcia, Marine Cazaux, Eleanor J. Cheadle
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2019, 216 (5), pp.1038-1049. ⟨10.1084/jem.20182375⟩
Journal of Experimental Medicine, 216(5), 1038-1049
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2019, 216 (5), pp.1038-1049. ⟨10.1084/jem.20182375⟩
Cazaux, M, Grandjean, C L, Lemaître, F, Garcia, Z, Beck, R J, Milo, I, Postat, J, Beltman, J B, Cheadle, E J & Bousso, P 2019, ' Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity ', The Journal of experimental medicine . https://doi.org/10.1084/jem.20182375
Journal of Experimental Medicine, Rockefeller University Press, 2019, 216 (5), pp.1038-1049. ⟨10.1084/jem.20182375⟩
Journal of Experimental Medicine, 216(5), 1038-1049
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2019, 216 (5), pp.1038-1049. ⟨10.1084/jem.20182375⟩
Cazaux, M, Grandjean, C L, Lemaître, F, Garcia, Z, Beck, R J, Milo, I, Postat, J, Beltman, J B, Cheadle, E J & Bousso, P 2019, ' Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity ', The Journal of experimental medicine . https://doi.org/10.1084/jem.20182375
Cazaux et al. use intravital imaging to dissect anti-CD19 CAR T cell activity. This study uncovers both anatomical and functional diversity in the outcome of anti-CD19 CAR T cell interactions with tumor cells impacting engraftment, killing dynamics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb2da5213b4da54fdce8125811ce2b3
https://hal.archives-ouvertes.fr/hal-02302284/document
https://hal.archives-ouvertes.fr/hal-02302284/document
Autor:
Christopher J. Holland, Paul L Ryan, Nital Sumaria, Claire M. Bradford, Daniel J. Pennington, Lesley A. Bergmeier, Ali S M Jawad, Natalia Izotova, Capucine L. Grandjean
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(50)
Human γδ T cells display potent responses to pathogens and malignancies. Of particular interest are those expressing a γδ T-cell receptor (TCR) incorporating TCRδ-chain variable-region-2 [Vδ2(+)], which are activated by pathogen-derived phospho
Autor:
David Michonneau, Béatrice Breart, Christian Gerdes, Fabricio Montalvao, Capucine L. Grandjean, Philippe Bousso, Zacarias Garcia, Susanna Celli, Olivier Freytag, Mario Perro
Publikováno v:
Scientific Reports
Scientific Reports, 2016, 6, pp.361-7. ⟨10.1038/srep34382⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.361-7. ⟨10.1038/srep34382⟩
Scientific Reports, 2016, 6, pp.361-7. ⟨10.1038/srep34382⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.361-7. ⟨10.1038/srep34382⟩
Anti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3dff4c65203d1362f1db3cd84fe904
https://hal-pasteur.archives-ouvertes.fr/pasteur-01403272
https://hal-pasteur.archives-ouvertes.fr/pasteur-01403272