Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Capsid engineering"'
Autor:
Suzanne Scott, Adrian Westhaus, Deborah Nazareth, Marti Cabanes-Creus, Renina Gale Navarro, Deborah Chandra, Erhua Zhu, Aravind Venkateswaran, Ian E. Alexander, Denis C. Bauer, Laurence O.W. Wilson, Leszek Lisowski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101351- (2024)
Gene therapies using recombinant adeno-associated virus (AAV) vectors have demonstrated considerable clinical success in the treatment of genetic disorders. Improved vectors with favorable tropism profiles, decreased immunogenicity, and enhanced manu
Externí odkaz:
https://doaj.org/article/6a6bf17f07fb448284aae0543a3f1d82
Autor:
Anais Defois, Nina Bon, Mathieu Mével, David Deniaud, Yves Maugars, Jérôme Guicheux, Oumeya Adjali, Claire Vinatier
Publikováno v:
Journal of Cartilage & Joint Preservation, Vol 4, Iss 2, Pp 100186- (2024)
Introduction: Osteoarthritis (OA), the most common form of joint disease, affects more than 500 million people worldwide. This painful and debilitating disease imposes a huge socioeconomic cost worldwide. Despite years of promising research, no etiol
Externí odkaz:
https://doaj.org/article/88140a72be4d4f7b9fc8ae02b09f9ce1
Autor:
Yoko Marwidi, Hoang-Oanh B. Nguyen, David Santos, Tenzin Wangzor, Sumita Bhardwaj, Gabriel Ernie, Gregg Prawdzik, Garrett Lew, David Shivak, Michael Trias, Jada Padilla, Hung Tran, Kathleen Meyer, Richard Surosky, Alex Michael Ward
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101228- (2024)
Manufacturing of adeno-associated viruses (AAV) for gene and cell therapy applications has increased significantly and spurred development of improved mammalian and insect cell-based production systems. We developed a baculovirus-based insect cell pr
Externí odkaz:
https://doaj.org/article/cc8de2e15a6c4613942f48ea926bb8b5
Autor:
Martin Bentler, Romain Hardet, Moritz Ertelt, Daniela Rudolf, Dorota Kaniowska, Andreas Schneider, Florian W.R. Vondran, Clara T. Schoeder, Marion Delphin, Julie Lucifora, Michael Ott, Ulrich T. Hacker, Sahil Adriouch, Hildegard Büning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 576-592 (2023)
De novo immune responses are considered major challenges in gene therapy. With the aim to lower innate immune responses directly in cells targeted by adeno-associated virus (AAV) vectors, we equipped the vector capsid with a peptide known to interfer
Externí odkaz:
https://doaj.org/article/653f4c03268045f68435d394aae772b1
Autor:
Ann-Christin Franke, Romain Hardet, Lisa Prager, Martin Bentler, Mélanie Demeules, Philipp John-Neek, Nico Martin Jäschke, Teng Cheong Ha, Ulrich Thorsten Hacker, Sahil Adriouch, Hildegard Büning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 238-253 (2023)
Immunotherapy has significantly improved treatment outcomes in various cancer entities. To enhance immunogenicity and efficacy, and to further broaden its applicability, co-administration of anti-tumor vaccines is considered as a promising strategy.
Externí odkaz:
https://doaj.org/article/60289b2c07f7465484685690b5e11a75
Autor:
Fuhua Wu, Shuang Luo, Yongshun Zhang, Yangsen Ou, Hairui Wang, Zhaofei Guo, Chunting He, Shuting Bai, Penghui He, Min Jiang, Xiaoyan Chen, Guangsheng Du, Xun Sun
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2219-2233 (2023)
Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines, the epidemic prevention and control are still challenging. Here, we employ a capsid and antigen structure engineering (CASE)
Externí odkaz:
https://doaj.org/article/09a3494bedc844a8a47c7d85dbcee381
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Parvoviruses are promising anticancer and gene therapy agents, but a deep knowledge of the entry process is crucial to exploit their therapeutic potential. We addressed this issue while attempting to retarget the oncolytic parvovirus minute virus of
Externí odkaz:
https://doaj.org/article/2717f8e570084b4e80451ff5bbf578bf
Autor:
Alexander Michels, Annika M. Frank, Dorothee M. Günther, Mehryad Mataei, Kathleen Börner, Dirk Grimm, Jessica Hartmann, Christian J. Buchholz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 334-347 (2021)
Preclinical studies on gene delivery into mouse lymphocytes are often hampered by insufficient activity of lentiviral (LV) and adeno-associated vectors (AAVs) as well as missing tools for cell type selectivity when considering in vivo gene therapy. H
Externí odkaz:
https://doaj.org/article/af713ec8eb904a748c49f07e9595bc48