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A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

Autor: Leslie, Theresa K., Tripp, Aurelien, James, Andrew D., Fraser, Scott P., Nelson, Michaela, Sajjaboontawee, Nattanan, Capatina, Alina L., Toss, Michael, Fadhil, Wakkas, Salvage, Samantha C., Garcia, Mar Arias, Beykou, Melina, Rakha, Emad, Speirs, Valerie, Bakal, Chris, Poulogiannis, George, Djamgoz, Mustafa B. A., Jackson, Antony P., Matthews, Hugh R., Huang, Christopher L-H, Holding, Andrew N., Chawla, Sangeeta, Brackenbury, William J.

Publikováno v: Oncogene; 20240101, Issue: Preprints p1-17, 17p

Inhibition of the Na⁺/K⁺-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation.

Autor: Shandell, Mia A.^1,2,3, Capatina, Alina L.^1,3, Lawrence, Samantha M.¹, Brackenbury, William J.^1,3, Lagos, Dimitris^2,3 dimitris.lagos@york.ac.uk

Publikováno v: Journal of Biological Chemistry. Mar2022, Vol. 298 Issue 3, p1-15. 15p.

A novel Na v 1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis.

Autor: Leslie TK; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Tripp A; Division of Cancer Biology, Institute of Cancer Research, London, UK., James AD; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Fraser SP; Department of Life Sciences, Imperial College London, London, UK., Nelson M; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Sajjaboontawee N; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Capatina AL; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Toss M; Department of Pathology, School of Medicine, University of Nottingham, Nottingham, UK., Fadhil W; Department of Pathology, School of Medicine, University of Nottingham, Nottingham, UK., Salvage SC; Department of Biochemistry, University of Cambridge, Cambridge, UK., Garcia MA; Division of Cancer Biology, Institute of Cancer Research, London, UK., Beykou M; Division of Cancer Biology, Institute of Cancer Research, London, UK.; Department of Electrical and Electronic Engineering, Imperial College London, London, UK., Rakha E; Department of Pathology, School of Medicine, University of Nottingham, Nottingham, UK., Speirs V; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Bakal C; Division of Cancer Biology, Institute of Cancer Research, London, UK., Poulogiannis G; Division of Cancer Biology, Institute of Cancer Research, London, UK., Djamgoz MBA; Department of Life Sciences, Imperial College London, London, UK.; Biotechnology Research Centre, Cyprus International University, Haspolat, TRNC, Mersin, Turkey., Jackson AP; Department of Biochemistry, University of Cambridge, Cambridge, UK., Matthews HR; Department of Biochemistry, University of Cambridge, Cambridge, UK., Huang CL; Department of Biochemistry, University of Cambridge, Cambridge, UK.; Physiological Laboratory, University of Cambridge, Cambridge, UK., Holding AN; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Chawla S; Department of Biology, University of York, York, UK.; York Biomedical Research Institute, University of York, York, UK., Brackenbury WJ; Department of Biology, University of York, York, UK. william.brackenbury@york.ac.uk.; York Biomedical Research Institute, University of York, York, UK. william.brackenbury@york.ac.uk.

Publikováno v: Oncogene [Oncogene] 2024 Aug; Vol. 43 (34), pp. 2578-2594. Date of Electronic Publication: 2024 Jul 25.