Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Caolin Wang"'
Autor:
Caolin Wang, Shan Xu, Liang Peng, Bingliang Zhang, Hong Zhang, Yingying Hu, Pengwu Zheng, Wufu Zhu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 203-217 (2019)
A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six
Externí odkaz:
https://doaj.org/article/b6667df4acdd496db8d0f8b03a20c120
Autor:
Yuanbiao Tu, Caolin Wang, Zunhua Yang, Bingbing Zhao, Luogen Lai, Qi Yang, Pengwu Zheng, Wufu Zhu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 462-478 (2018)
Aimed at discovering effective EGFR inhibitors, six series of quinazoline derivatives bearing a semicarbazone moiety were designed, synthesized and evaluated in different cancer cell lines (A549, HepG2, MCF-7 and PC-3). Most of the selected compounds
Externí odkaz:
https://doaj.org/article/ee56ad5b4a9649ee836c8b9185c0f7e9
Autor:
Lide Yu, Qinqin Wang, Caolin Wang, Binliang Zhang, Zunhua Yang, Yuanying Fang, Wufu Zhu, Pengwu Zheng
Publikováno v:
Molecules, Vol 24, Iss 19, p 3422 (2019)
Three series of novel thienopyrimidine derivatives 9a−l, 15a−l, and 18a−h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicit
Externí odkaz:
https://doaj.org/article/cd9a5b279d8547d7ba87fbbd38d36a8e
Publikováno v:
Molecules, Vol 23, Iss 7, p 1553 (2018)
Five series of novel phenylsulfonylurea derivatives, 19a–d, 20a–d, 21a–d, 22a–d and 23a–d, bearing 4-phenylaminoquinoline scaffold were designed, synthesized and their IC50 values against four cancer cell lines (HepG-2, A549, PC-3 and MCF-7
Externí odkaz:
https://doaj.org/article/48ccffc2960e4f138645d10ba69703bf
Publikováno v:
Molecules, Vol 21, Iss 11, p 1447 (2016)
Four series of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives 11a–j, 12a–j, 13a–g and 14a–g bearing phenylpyridine/phenylpyrimidine- carboxamide scaffolds were designed, synthesized and their IC50 values against thr
Externí odkaz:
https://doaj.org/article/d8de94e3b20a46a8a4a522cea8ae3d40
Autor:
Huan Ge, Caolin Wang, Chaoquan Tian, Yanyan Diao, Wanqi Wang, Xiangyu Ma, Jian Zhang, Honglin Li, Zhenjiang Zhao, Lili Zhu
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 156
Hyperactivation of the Janus kinase 2 (JAK2) signaling pathway leads to myeloproliferative neoplasms (MPNs) and targeting JAK2 can be used as an effective strategy for the treatment of MPNs. Here, our study indicated that WWQ-131 was a highly selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60b42f4836a75c2f7cd87b89d92e5d0
https://pubmed.ncbi.nlm.nih.gov/36306591
https://pubmed.ncbi.nlm.nih.gov/36306591
Autor:
Dou Dou, Jie Wang, Yunjin Qiao, Gulinuer Wumaier, Wenjie Sha, Wenjie Li, Wenyi Mei, Tingyuan Yang, Chen Zhang, Huan He, Caolin Wang, Linna Chu, Baihui Sun, Rongrong Su, Xiangyu Ma, Mengdie Gong, Lijuan Xie, Wenzhe Jiang, Yanyan Diao, Lili Zhu, Zhenjiang Zhao, Zhuo Chen, Yufang Xu, Shengqing Li, Honglin Li
Publikováno v:
European journal of medicinal chemistry. 244
Epidermal growth factor receptor (EGFR) is an effective drug target for the treatment of non-small cell lung cancer (NSCLC). However, a tertiary point mutation (C797S) at the ATP binding pocket of the EGFR induces resistance to the third-generation E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ba0ffe6f9ca5cdb219ea3a4161617e
https://pubmed.ncbi.nlm.nih.gov/36279692
https://pubmed.ncbi.nlm.nih.gov/36279692
Autor:
Wenhui, Gan, Caolin, Wang, Qingshan, Pan, Yuzhen, Li, Yuping, Guo, Dang, Fan, Yuting, Peng, Zixuan, Rao, Shan, Xu, Pengwu, Zheng, Wufu, Zhu
Publikováno v:
Bioorganic chemistry. 127
Three series of quinazoline derivatives (7a-j, 8a-o, 9a-l) were designed and synthesized as EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2a4abaedc4727a9f93254dd89c0872b
https://pubmed.ncbi.nlm.nih.gov/35792314
https://pubmed.ncbi.nlm.nih.gov/35792314
Autor:
Wufu Zhu, Caolin Wang, Hong Zhang, Xiuying Chen, Bingbing Zhao, Pengwu Zheng, Shuang Jia, Yiqiang OuYang
Publikováno v:
Letters in Drug Design & Discovery. 16:533-546
Background: Cancer continues to pose a great problem and burden on society despite new treatment options. While surgery, radiotherapy, and chemotherapy have led to major improvements in patient prognosis, newer treatments are needed to more effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1c091e2309d91df4a78687caeda061
https://doi.org/10.2174/1570180815666180801121220
https://doi.org/10.2174/1570180815666180801121220
Autor:
Pengwu Zheng, Bingliang Zhang, Shan Xu, Wufu Zhu, Caolin Wang, Liang Peng, Yingying Hu, Hong Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 203-217 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 203-217 (2019)
A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646773eb4da1f5c62a8efd3d7e600738
https://doi.org/10.1080/14756366.2018.1518957
https://doi.org/10.1080/14756366.2018.1518957