Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Caoimhin S, Griffin"'
Autor:
Vivek Krishnan, Sher Ali, Albert L Gonzales, Pratish Thakore, Caoimhin S Griffin, Evan Yamasaki, Michael G Alvarado, Martin T Johnson, Mohamed Trebak, Scott Earley
Publikováno v:
eLife, Vol 11 (2022)
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs). The mechanisms responsible for these membra
Externí odkaz:
https://doaj.org/article/6220d6fe82c7448f89f4c6b70dff3cf1
Autor:
Xin Rui Lim, Eamonn Bradley, Gerard P. Sergeant, Keith D. Thornbury, Caoimhin S. Griffin, Mark A. Hollywood
Publikováno v:
British Journal of Pharmacology. 179:1082-1101
Background and purpose Corpus cavernosum smooth muscle (CCSM) exhibits phasic contractions that are coordinated by ion channels. Mouse models are commonly used to study erectile dysfunction, but there are few published electrophysiological studies of
Autor:
Ruth M, Matthews, Eamonn, Bradley, Caoimhin S, Griffin, Xin Rui, Lim, Nicolas D, Mullins, Mark A, Hollywood, Fionnuala T, Lundy, Lorcan P, McGarvey, Gerard P, Sergeant, Keith D, Thornbury
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Isolated smooth muscle cells (SMCs) from mouse bronchus were studied using the whole cell patch-clamp technique at ∼21°C. Stepping from -100 mV to -20 mV evoked inward currents of mean amplitude -275 pA. These inactivated (tau = 1.1 ms) and were a
Autor:
Bernard T. Drumm, Caoimhin S. Griffin, Vivek Krishnan, Kenton M. Sanders, Sher Ali, Eleanor M. Nagle, Scott Earley, Michael G. Alvarado, Evan Yamasaki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Significance TRPML1 (transient receptor potential mucolipin 1) is a Ca2+-permeable, nonselective cation channel that is localized to late endosomes and lysosomes. Here, we investigated the function of TRPML1 channels in regulating lower urinary tract
Autor:
Pratish Thakore, Albert L Gonzales, Sher Ali, Vivek Krishnan, Caoimhin S Griffin, Evan Yamasaki, Michael G Alvarado, Martin T Johnson, Mohamed Trebak, Scott Earley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076f0b299611eae56fc6e881a41979f5
https://doi.org/10.7554/elife.70278.sa2
https://doi.org/10.7554/elife.70278.sa2
Autor:
Caoimhin S. Griffin, Mark A. Hollywood, Gerard P. Sergeant, Keith D. Thornbury, Zhihui Fong, Roddy J. Large
Publikováno v:
Proc Natl Acad Sci U S A
P2X1 receptors are adenosine triphosphate (ATP)-gated cation channels that are functionally important for male fertility, bladder contraction, and platelet aggregation. The activity of P2X1 receptors is modulated by lipids and intracellular messenger
Autor:
Pratish Thakore, Albert L Gonzales, Sher Ali, Vivek Krishnan, Caoimhin S Griffin, Evan Yamasaki, Michael G Alvarado, Martin T Johnson, Mohamed Trebak, Scott Earley
Publikováno v:
eLife. 11
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs). The mechanisms responsible for these membra
Autor:
Harry A. T. Pritchard, Pratish Thakore, Caoimhin S. Griffin, Scott Earley, Conor Lane, Adam Greenstein, Evan Yamasaki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Pritchard, H A T, Griffin, C S, Yamasaki, E, Thakore, P, Lane, C, Greenstein, A S & Earley, S 2019, ' Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 43, pp. 21874-21881 . https://doi.org/10.1073/pnas.1911304116
Pritchard, H A T, Griffin, C S, Yamasaki, E, Thakore, P, Lane, C, Greenstein, A S & Earley, S 2019, ' Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 43, pp. 21874-21881 . https://doi.org/10.1073/pnas.1911304116
Significance The junctophilins are a family of structural proteins that organize intracellular membrane junctions, such as coupling between the endoplasmic/sarcoplasmic reticulum and plasma membrane. The junctophilins are critically important for car
Publikováno v:
American Journal of Physiology-Cell Physiology. 317:C131-C142
β3-Adrenoceptor (β3-AR) agonists are used to treat overactive bladder syndrome; however, their mechanism of action has not been determined. The aims of this study were to compare the effects of β3-AR agonists on cholinergic versus purinergic recep
Autor:
Pratish, Thakore, Harry A T, Pritchard, Caoimhin S, Griffin, Evan, Yamasaki, Bernard T, Drumm, Conor, Lane, Kenton M, Sanders, Yumei, Feng Earley, Scott, Earley
Publikováno v:
Sci Signal
In this issue of Science Signaling, Thakore et al. report that the Ca(2+) permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca(2+) sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 chan