Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Caoimhín G. Concannon"'
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 66K, Temporal protein profiles for HeLa cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b189d3e810ceafc43ebc78889248b659
https://doi.org/10.1158/0008-5472.22399179
https://doi.org/10.1158/0008-5472.22399179
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 53K, Temporal protein profiles for HCT-116 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749a5e65e13ffae8d959c3e85c1b4481
https://doi.org/10.1158/0008-5472.22399176.v1
https://doi.org/10.1158/0008-5472.22399176.v1
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 237K, Supplementary Table 1: Translation of protein interactions into Ordinary Differential Equations. Supplementary Table 2: Pseudo-reactions for degradation and degradation rates as used in the model. Supplementary Table 3: Pseudo-reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d8544002f138be36db9e0356b6ba94
https://doi.org/10.1158/0008-5472.22399170.v1
https://doi.org/10.1158/0008-5472.22399170.v1
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 52K, Systems modeling can act as a clinical tool to determine therapeutic windows and to assess adjuvant treatments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d0cd6af1762a0562109f89bc9773a1
https://doi.org/10.1158/0008-5472.22399173.v1
https://doi.org/10.1158/0008-5472.22399173.v1
Autor:
Annette T. Byrne, Frank E. Murray, Niamh McCawley, Caoimhín G. Concannon, Karen Boland, Deborah A. McNamara, Jochen H. M. Prehn, Elaine W. Kay, Ritesh M. Pabari, Lorna Flanagan, Zebunnissa Ramtoola
Publikováno v:
European Journal of Pharmacology. 780:53-64
Deregulation of the ubiquitin-proteasome pathway has been frequently observed in a number of malignancies. Using quantitative Western blotting of normal and matched tumour tissue, we here identified a significant increase in the 19S proteasome subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd2ecbed179865805f72a26d497bc6e
https://doi.org/10.1016/j.ejphar.2016.03.031
https://doi.org/10.1016/j.ejphar.2016.03.031
Publikováno v:
The Journal of biological chemistry. 293(47)
In response to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 (IRE1), PRKR-like ER kinase (PERK), and activating transcription factor 6α (ATF6α),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f746f4f36789319c171aa192f27909b
https://pubmed.ncbi.nlm.nih.gov/30287689
https://pubmed.ncbi.nlm.nih.gov/30287689
Autor:
Jochen H. M. Prehn, Jasmin Schmid, Ailbhe McCarthy, Marie Burke, Britta Engelbrecht, Shona Pfeiffer, Siobhan Bacon, Caoimhín G. Concannon, Ross Gallagher, Maria M. Byrne
Publikováno v:
Genes, Vol 6, Iss 2, Pp 399-416 (2015)
Genes
Volume 6
Issue 2
Pages 399-416
Genes
Volume 6
Issue 2
Pages 399-416
MicroRNA (miRNA) are a class of non-coding, 19–25 nucleotide RNA critical for network-level regulation of gene expression. miRNA serve as paracrine signaling molecules. Using an unbiased array approach, we previously identified elevated levels of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8138cadbbfb9e9cf4142d2fdfad4016e
https://doi.org/10.3390/genes6020399
https://doi.org/10.3390/genes6020399
Autor:
Katie Nolan, Caoimhín G. Concannon, Mollie R. Mitchem, Jochen H. M. Prehn, Eva M. Jimenez-Mateos, David C. Henshall
Publikováno v:
Journal of Molecular Neuroscience. 53:231-241
Endoplasmic reticulum (ER) stress has been implicated in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). MicroRNAs are small ribonucleic acids which can modulate protein expression by binding to the 3'UTR of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a789148616f1436c375ef5512c2d4a6f
https://doi.org/10.1007/s12031-014-0290-y
https://doi.org/10.1007/s12031-014-0290-y
Autor:
Caoimhín G. Concannon, Jochen H. M. Prehn, Douglas R. Green, Andreas U. Lindner, Elaine W. Kay, Fabien Llambi, Heinrich J. Huber, Deborah Ryan, Suzanne Hector, Karen Boland, Deborah A. McNamara, Joan Kehoe, Mary Cannon, Gerhardt J. Boukes, Frank E. Murray
Publikováno v:
Cancer Research; Vol 73
Apoptotic desensitization is a hallmark of cancer cells, but present knowledge of molecular systems controlling apoptosis has yet to provide significant prognostic insights. Here, we report findings from a systems study of the intrinsic pathway of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14f5e2cabb5b908cbd808a409235bc6
Autor:
Donat Kögel, Rupert Egensperger, Simone Poeschel, Steffi Chang, Caroline Bonner, Hildegard König, Jochen H. M. Prehn, Caoimhín G. Concannon, Thorsten Müller
Publikováno v:
Neurobiology of Aging. 33:2200-2209
Here we employed human SHEP neuroblastoma cells either stably or inducibly expressing the amyloid precursor protein (APP) intracellular domain (AICD) to investigate its ability to modulate stress-induced cell death. Analysis of effector caspase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1e090fd394142300a16b2258d64fd3
https://doi.org/10.1016/j.neurobiolaging.2011.06.012
https://doi.org/10.1016/j.neurobiolaging.2011.06.012