Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Cao-Qi Lei"'
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract MITA (also known as STING) is an ER-located adaptor protein, which mediates DNA-triggered innate immune response and is critically involved in autoimmune diseases and tumorigenesis. MITA is regulated by post-translational modifications, but
Externí odkaz:
https://doaj.org/article/6f19ecee91604a91bd9a3077f189b38c
Autor:
Yan Zeng, Shuai Xu, Yanli Wei, Xuegang Zhang, Qian Wang, Yane Jia, Wanbing Wang, Lu Han, Zhaoshan Chen, Zhengxiang Wang, Bo Zhang, Hualan Chen, Cao-Qi Lei, Qiyun Zhu
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009300 (2021)
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified the PB1 protein of H7N9 virus as a new negati
Externí odkaz:
https://doaj.org/article/538291fff6874762bc9ab34c73220efb
Autor:
Yan-Ran Xu, Cao-Qi Lei
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assem
Externí odkaz:
https://doaj.org/article/cac275ec80694448b07573dbf84d5b9e
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008457 (2020)
The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regula
Externí odkaz:
https://doaj.org/article/cb403c639c9046ddafdb4cde4c50156f
Autor:
Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation follo
Externí odkaz:
https://doaj.org/article/787e1f46425144ed98d0dc92723cdac6
Autor:
Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/6bbe448f6a6e4e3688bfcad46115a65d
Autor:
Shilin Tian, Jiaming Zeng, Hengwu Jiao, Dejing Zhang, Libiao Zhang, Cao-qi Lei, Stephen J. Rossiter, Huabin Zhao
Publikováno v:
Science Advances. 9
Bats have been identified as natural reservoir hosts of several zoonotic viruses, prompting suggestions that they have unique immunological adaptations. Among bats, Old World fruit bats (Pteropodidae) have been linked to multiple spillovers. To test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6228fd899c34cffc7cd31644b8e4773
https://doi.org/10.1126/sciadv.add0141
https://doi.org/10.1126/sciadv.add0141
Publikováno v:
Autophagy.
Mitophagy is a form of autophagy that plays a key role in maintaining the homeostasis of functional mitochondria in the cell. Viruses have evolved various strategies to manipulate mitophagy to escape host immune responses and promote virus replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fe6516e5fd5a76959f7912b0965b84
https://pubmed.ncbi.nlm.nih.gov/36588386
https://pubmed.ncbi.nlm.nih.gov/36588386
Autor:
Yan-Ran Xu, Meng-Ling Shi, Yu Zhang, Na Kong, Cong Wang, Yi-Feng Xiao, Shi-Shen Du, Qi-Yun Zhu, Cao-Qi Lei
Publikováno v:
Proceedings of the National Academy of Sciences. 119
During viral infection, sensing of viral RNA by retinoic acid–inducible gene-I–like receptors (RLRs) initiates an antiviral innate immune response, which is mediated by the mitochondrial adaptor protein VISA (virus-induced signal adaptor; also kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d88f9458cc9841a725b3ff1e809d549
https://doi.org/10.1073/pnas.2122805119
https://doi.org/10.1073/pnas.2122805119
Publikováno v:
Cell Mol Immunol
Cyclic GMP-AMP synthase (cGAS) is a key sensor critical for the recognition of DNA in the cytosol and catalyzes the synthesis of the second messenger cyclic GMP-AMP (cGAMP), which binds to the adapter protein MITA (also known as STING, MPYS, and ERIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba15e3297f96dc31769587589c00c5a3
https://doi.org/10.1038/s41423-020-0462-3
https://doi.org/10.1038/s41423-020-0462-3