Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

Autor: Geraldine M Clarke, Kirk Rockett, Katja Kivinen, Christina Hubbart, Anna E Jeffreys, Kate Rowlands, Muminatou Jallow, David J Conway, Kalifa A Bojang, Margaret Pinder, Stanley Usen, Fatoumatta Sisay-Joof, Giorgio Sirugo, Ousmane Toure, Mahamadou A Thera, Salimata Konate, Sibiry Sissoko, Amadou Niangaly, Belco Poudiougou, Valentina D Mangano, Edith C Bougouma, Sodiomon B Sirima, David Modiano, Lucas N Amenga-Etego, Anita Ghansah, Kwadwo A Koram, Michael D Wilson, Anthony Enimil, Jennifer Evans, Olukemi K Amodu, Subulade Olaniyan, Tobias Apinjoh, Regina Mugri, Andre Ndi, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Norbert Peshu, Thomas N Williams, Alphaxard Manjurano, Nuno Sepúlveda, Taane G Clark, Eleanor Riley, Chris Drakeley, Hugh Reyburn, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Sarah J Dunstan, Nguyen Hoan Phu, Nguyen Ngoc Quyen, Cao Quang Thai, Tran Tinh Hien, Laurens Manning, Moses Laman, Peter Siba, Harin Karunajeewa, Steve Allen, Angela Allen, Timothy ME Davis, Pascal Michon, Ivo Mueller, Síle F Molloy, Susana Campino, Angeliki Kerasidou, Victoria J Cornelius, Lee Hart, Shivang S Shah, Gavin Band, Chris CA Spencer, Tsiri Agbenyega, Eric Achidi, Ogobara K Doumbo, Jeremy Farrar, Kevin Marsh, Terrie Taylor, Dominic P Kwiatkowski, MalariaGEN Consortium

Publikováno v: eLife, Vol 6 (2017)

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effect has proved difficult to define as G6PD deficiency has multiple allelic variant

Externí odkaz: https://doaj.org/article/f05449c1a20b4490b6413ada919611ca

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Reappraisal of known malaria resistance loci in a large multicenter study

Autor: Malcolm E. Molyneux, Peter Siba, Andre Ndi, Valentina D. Mangano, Cao Quang Thai, Vysaul Nyirongo, Subulade A. Olaniyan, Angie Green, Mahamadou A. Thera, Timothy M. E. Davis, Síle F. Molloy, Kathryn Fitzpatrick, Giorgio Sirugo, Edith C. Bougouma, Chris Drakeley, Anthony Enimil, Angela Allen, Olukemi K. Amodu, Christina Hubbart, Nuno Sepúlveda, Nguyen Hoan Phu, M Jallow, Carolyne M. Ndila, Stanley Usen, Kimberly J. Johnson, Hugh Reyburn, Taane G. Clark, Dominic P. Kwiatkowski, Si Quang Le, Tobias O. Apinjoh, Kalifa Bojang, Jennifer R Evans, Michael D. Wilson, Lee Hart, Sophie Uyoga, Angeliki Kerasidou, Eric A. Achidi, Steve Allen, Kirk A. Rockett, Pascal Michon, Ivo Mueller, Anna E. Jeffreys, Belco Poudiougou, Anita Ghansah, Norbert Peshu, Fatoumatta Sisay-Joof, David Kachala, Sodiomon B. Sirima, David J. Conway, Geraldine M. Clarke, Regina N. Mugri, Moses Laman, Aaron Vanderwal, Miguel A. Sanjoaquin, Sibiry Sissoko, Ousmane Touré, Laurens Manning, Chris C. A. Spencer, Matti Pirinen, David Modiano, Sarah J. Dunstan, Harin Karunajeewa, Alexander Macharia, Tran Tinh Hien, Tsiri Agbenyega, Gavin Band, Kate Rowlands, Salimata Konate, Rachel Craik, L. Amenga-Etego, Nguyen Ngoc Quyen, Kwadwo A. Koram, Amadou Niangaly, Margaret Pinder, Alphaxard Manjurano, Terrie E. Taylor, Ogobara K. Doumbo, Eleanor M. Riley, Jeremy Farrar, Victoria Cornelius, Kevin Marsh, Thomas N. Williams

Publikováno v: Nature genetics

Many human genetic associations with resistance to malaria have been reported, but few have been reliably replicated. We collected data on 11,890 cases of severe malaria due to Plasmodium falciparum and 17,441 controls from 12 locations in Africa, As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717b83ca63cd08f7da9dda709ed341e2
https://doi.org/10.1038/ng.3107

Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese

Autor: Dominic P. Kwiatkowski, Anne Jeffreys, Kirk A. Rockett, Tran Tinh Hien, Sarah J. Dunstan, Cao Quang Thai, Nguyen T. Hang, Nguyen Hoan Phu, Nicholas P. J. Day, Kerrin S. Small, Nguyen Than Ha Quyen, Taane G. Clark, Jj J. Farrar, Sean O’Riordan, Cameron P. Simmons, Yik Ying Teo

The genetic basis for susceptibility to malaria has been studied widely in African populations but less is known of the contribution of specific genetic variants in Asian populations. We genotyped 67 single-nucleotide polymorphisms (SNPs) in 1030 sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3a555016686b2851ebde43681e5b19
https://ora.ox.ac.uk/objects/uuid:a8a5734a-fdb3-40d6-a9a4-9d211b02affb

A randomized comparison of chloroquine versus dihydroartemisinin-piperaquine for the treatment of Plasmodium vivax infection in Vietnam

Autor: Le Hong Thai, Nicholas J. White, Nguyen Thanh Thuy Nhien, Pham Van Toi, Cao Quang Thai, Marcel Wolbers, Tran Tinh Ngoc Khanh, Tran Tinh Hien, Le Thanh Dong, Phung Duc Thuan, Jeremy Farrar, Guy E. Thwaites, Nhu Thi Hoa, Nguyen Duc Anh, Ho Thi Nhan, Nguyen Thuy Nha Ca, Do Hung Son, Ngo Viet Thanh, Christiane Dolecek, Mai Anh Loi, Nguyen Hoan Phu

Publikováno v: The American Journal of Tropical Medicine and Hygiene

A total of 128 Vietnamese patients with symptomatic Plasmodium vivax mono-infections were enrolled in a prospective, open-label, randomized trial to receive either chloroquine or dihydroartemisinin–piperaquine (DHA-PPQ). The proportions of patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e3876ffb192445796a875c69f9c53b
http://ora.ox.ac.uk/objects/uuid:03c239f4-eff4-40bb-aeb8-71805a049b2f