Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Cao, Lv"'
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Abstract 2634: AMB302/GR1017, an antibody-drug conjugate (ADC) with topoisomerase 1 inhibitor shows therapeutic potency in orthotopic glioblastoma PDX and bladder cancer models with FGFR3-TACC3 fusion
Autor: Byeongkwi Min, Lily Shi, Hye Jin Kim, Sangwoo Kim, Beibei Fan, Cao Lv, Yajun Sun, Nam-Gu Her, Paul Song, Gang Qin, Do-Hyun Nam
Publikováno v: Cancer Research. 83:2634-2634
Background: FGFR3-TACC3 (F3-T3) fusion leads to FGFR3 kinase activation constitutively and acts as a driver mutation in several solid tumors. AMB302/GR1017 is a novel FGFR3 targeting ADC that was developed using the intelligent Ligase-Dependent Conju
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d502f3769d7c63bd37a1434aa306d084
https://doi.org/10.1158/1538-7445.am2023-2634
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3
Abstract 2640: An innovative site-specific dual-payload antibody drug conjugate (dpADC) combining a novel Topo1 inhibitor and an immune agonist delivers a strong immunogenic cell death (ICD) and antitumor response in vitro and in vivo
Autor: Meijun Xiong, Beibei Fan, Xinju Gao, Yajun Sun, Cao Lv, Yu Si, Xiao Liu, Lili Shi, Paul H. Song, Gang Qin
Publikováno v: Cancer Research. 83:2640-2640
Background: Antibody-drug conjugate, also known as a targeted chemotherapy, leverages the targeting feature of mAb and the efficient cell-killing ability of cytotoxin to deliver cytotoxic drugs to tumor specifically. Among the FDA approved 15 ADCs an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15b62ec76a3a058e6ff36c274fad37a3
https://doi.org/10.1158/1538-7445.am2023-2640
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4
Abstract 2702: GQ1001 is a next generation HER2-targeting ADC with excellent druggability, safety and potency
Autor: Lei Huang, Lili Shi, Yajun Sun, Cao Lv, Chengcheng Gong, Chong Liu, Jun Yang, Lu Jiang, Jinduo Yuan, Xuesong Li, Mingyu Hu, Xinju Gao, Yu Si, Hui Yang, Yan Shi, Bo Yang, Paul H. Song, Gang Qin, Biyun Wang
Publikováno v: Cancer Research. 83:2702-2702
Background: GQ1001 was developed to overcome the current limitation of existing HER2 ADCs by using the next generation site-specific conjugation and a stable linker technology, coined the intelligent ligase-dependent conjugation (iLDC) technology. iL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38cd748de66c9a723a3bb7fa856fa97c
https://doi.org/10.1158/1538-7445.am2023-2702
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5
RPS15A promotes the proliferation and migration of nasopharyngeal carcinoma
Autor: Jin Bian, Yan Niu, Cao Lv
Background: Nasopharyngeal carcinoma (NPC) is an epithelial squamous cell carcinoma arising from the nasopharyngeal mucosal lining. Ribosomal protein S15a (RPS15A) plays vital role in protein translation and was recently reported to be an oncogene in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6afdb06cc191f39fe8277c1522e7ecc
https://doi.org/10.21203/rs.3.rs-1358846/v1
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6
FOXG1 improves mitochondrial function and promotes the progression of nasopharyngeal carcinoma
Autor: Huajun Xi, Zhengxiang He, Cao Lv
Publikováno v: Molecular Medicine Reports
Forkhead-box gene 1 (FOXG1) has been reported to serve an important role in various malignancies, but its effects on nasopharyngeal cancer (NPC) remain unknown. Thus, the present study aimed to investigate the specific regulatory relationship between
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478cf48a82b57c0839deefd88f1ca278
https://pubmed.ncbi.nlm.nih.gov/34278485
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7
Automatic Recognition of Laryngoscopic Images Using a Deep‐Learning Technique
Autor: Min Chen, Ting Xiang, Ning Yang, Cao Lv, Jian Zou, Geoffrey Liu, Yongbo Zheng, Tao Lu, Xiujuan Zheng, Qiu-Yun Yang, Yang Xu, Jing Xueping, Jianjun Ren, Ruiqing Liu, Hui Yang, Yu Zhao, Ken Lin, Fan Lou, Lan-Zhi Ma, Yufang Rao, Xue Ren, Xianfeng Zheng, Yi Sun, Kai Liu, Wei Xu, Weigang Gan, Junnan An, Jing Wang
Publikováno v: Laryngoscope, 130(11), E686-E693. Wiley
Objectives/Hypothesis: To develop a deep-learning–based computer-aided diagnosis system for distinguishing laryngeal neoplasms (benign, precancerous lesions, and cancer) and improve the clinician-based accuracy of diagnostic assessments of laryngos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff1371b2d5abc06ee3fe8606d3ddc5d
https://doi.org/10.1002/lary.28539
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9
Numerical simulation study on cyclic reciprocal derivative chronopotentiometry of reversible electrode reaction coupled with Langmuir adsorption
Autor: Jian Chen, Luhong Chen, Shuping Bi, Cao Lv
Publikováno v: Electrochimica Acta. 93:222-229
Theoretical modeling and analyzing of reversible electrode reaction coupled with Langmuir adsorption is presented using cyclic reciprocal derivative chronopotentiometry (CRDCP) with symmetrical programmed current applied, in which the finite differen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d05720b6472bd9cd95e75245bc5858f6
https://doi.org/10.1016/j.electacta.2012.12.123
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10
Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway
Autor: Li Wang, Yong Li, Cao Lv, Hongping Song, Zhong Liu
Publikováno v: Biochemical and biophysical research communications. 478(2)
Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP). Here we show that niclosamide, a FDA-approved anthelmintic drug, enhances the sensitivity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958d51abfd652fb5b0f11f68f318fa9b
https://pubmed.ncbi.nlm.nih.gov/27520370
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