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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Publikováno v: Nature medicine, vol 25, iss 1
Hepatobiliary Surg Nutr
Wang, Z; Aguilar, EG; Luna, JI; Dunai, C; Khuat, LT; Le, CT; et al.(2018). Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nature Medicine. doi: 10.1038/s41591-018-0221-5. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/14v385n0

© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imp

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Survival benefits associated with surgery for advanced non–small cell lung cancer

Autor: David, EA, Andersen, SW, Beckett, LA, Melnikow, J, Clark, JM, Brown, LM, Cooke, DT, Kelly, K, Canter, RJ

Publikováno v: David, EA; Andersen, SW; Beckett, LA; Melnikow, J; Clark, JM; Brown, LM; et al.(2018). Survival benefits associated with surgery for advanced non–small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery. doi: 10.1016/j.jtcvs.2018.10.140. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/5xg9h3qp

© 2018 Objective: Overall survival (OS) for advanced stage (IIIA-IV) non–small cell lung cancer (NSCLC) is highly variable, and retrospective data show a survival advantage for patients receiving therapeutic intent pulmonary resection. We hypothes

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The Role of Thoracic Surgery in the Therapeutic Management of Metastatic Non–Small Cell Lung Cancer

Autor: David, EA, Clark, JM, Cooke, DT, Melnikow, J, Kelly, K, Canter, RJ

Publikováno v: David, EA; Clark, JM; Cooke, DT; Melnikow, J; Kelly, K; & Canter, RJ. (2017). The Role of Thoracic Surgery in the Therapeutic Management of Metastatic Non–Small Cell Lung Cancer. Journal of Thoracic Oncology, 12(11), 1636-1645. doi: 10.1016/j.jtho.2017.08.008. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3sx2n26m

© 2017 Introduction In most patients with NSCLC, the disease is diagnosed in an advanced stage, the prognosis is poor, and survival is typically measured in months. Standard therapeutic treatment regimens for patients with stage IV NSCLC typically i

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Increasing Rates of No Treatment in Advanced-Stage Non–Small Cell Lung Cancer Patients: A Propensity-Matched Analysis

Autor: David, EA, Daly, ME, Li, CS, Chiu, CL, Cooke, DT, Brown, LM, Melnikow, J, Kelly, K, Canter, RJ

Publikováno v: David, EA; Daly, ME; Li, CS; Chiu, CL; Cooke, DT; Brown, LM; et al.(2017). Increasing Rates of No Treatment in Advanced-Stage Non–Small Cell Lung Cancer Patients: A Propensity-Matched Analysis. Journal of Thoracic Oncology, 12(3), 437-445. doi: 10.1016/j.jtho.2016.11.2221. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/6zv5305q

© 2016 Introduction Variation in treatment and survival outcomes for NSCLC is high among patients with stage III or IV disease, but patients with untreated NSCLC have not been critically analyzed to evaluate for improvable outcomes. We evaluated tre

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