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4
Akademický článek
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Autor: Southall SM; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Banerjee J; Syngene International, Biocon Park, Bommasandra, Bangalore, Karnataka 560099, India., Brown J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Butkovic K; Selvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia., Cansfield AD; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Cansfield JE; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Congreve MS; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Cseke G; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Deflorian F; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom., Hunjadi MP; Selvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia., Hutinec A; Selvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia., Inturi TK; Syngene International, Biocon Park, Bommasandra, Bangalore, Karnataka 560099, India., Rupcic R; Selvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia., Saxty G; Selvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia., Watson SP; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Oct 19; Vol. 13 (11), pp. 1776-1782. Date of Electronic Publication: 2022 Oct 19 (Print Publication: 2022).
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5
Akademický článek
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
Autor: Cansfield AD; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Ator MA; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States., Banerjee J; Syngene International, Biocon Park, Bommasandra, Bangalore 560099, India., Bestwick M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Bortolato A; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Brown GA; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Brown J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Butkovic K; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Cansfield JE; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Christopher JA; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Congreve M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Cseke G; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Deflorian F; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Dugan B; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States., Hunjadi MP; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Hutinec A; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Inturi TK; Syngene International, Biocon Park, Bommasandra, Bangalore 560099, India., Landek G; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Mason J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., O'Brien A; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Ott GR; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States., Rupcic R; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Saxty G; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Southall SM; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Zadravec R; Fidelta d.o.o., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia., Watson SP; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2022 Mar 16; Vol. 13 (6), pp. 751-765. Date of Electronic Publication: 2022 Mar 04.
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6
Akademický článek
Structure-Based Drug Discovery of N -(( R )-3-(7-Methyl-1 H -indazol-5-yl)-1-oxo-1-((( S )-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3- d ][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
Autor: Bucknell SJ; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Ator MA; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States., Brown AJH; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Brown J; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Cansfield AD; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Cansfield JE; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Christopher JA; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Congreve M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Cseke G; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Deflorian F; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Jones CR; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Mason JS; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., O'Brien MA; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Ott GR; Teva Pharmaceuticals, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States., Pickworth M; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K., Southall SM; Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7906-7920. Date of Electronic Publication: 2020 Jul 08.
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7
Akademický článek
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.
Autor: Cansfield AD; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Ladduwahetty T; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Sunose M; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Ellard K; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Lynch R; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Newton AL; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Lewis A; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Bennett G; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Zinn N; Cellzome AG , Meyerhofstraße 1, 69117 Heidelberg, Germany., Thomson DW; Cellzome AG , Meyerhofstraße 1, 69117 Heidelberg, Germany., Rüger AJ; Cellzome AG , Meyerhofstraße 1, 69117 Heidelberg, Germany., Feutrill JT; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Rausch O; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Watt AP; Cellzome Ltd , Chesterford Research Park, Saffron Waldon, CB10 1XL, United Kingdom., Bergamini G; Cellzome AG , Meyerhofstraße 1, 69117 Heidelberg, Germany.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Jun 10; Vol. 7 (8), pp. 768-73. Date of Electronic Publication: 2016 Jun 10 (Print Publication: 2016).
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8
Akademický článek
Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked.
Autor: Scrace SF; Vernalis (R & D) Ltd, Granta Park, Great Abington, Cambridge, Cambs, UK., Kierstan P, Borgognoni J, Wang LZ, Denny S, Wayne J, Bentley C, Cansfield AD, Jackson PS, Lockie AM, Curtin NJ, Newell DR, Williamson DS, Moore JD
Publikováno v: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2008 Dec 15; Vol. 7 (24), pp. 3898-907. Date of Electronic Publication: 2008 Dec 04.
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