Knowledge-Informed Machine Learning for Cancer Diagnosis and Prognosis: A review

Autor: Mao, Lingchao, Wang, Hairong, Hu, Leland S., Tran, Nhan L, Canoll, Peter D, Swanson, Kristin R, Li, Jing

Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these advancements, machine

Externí odkaz: http://arxiv.org/abs/2401.06406

Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA

Autor: Xu Hua, Hui Zhou, Hui-Chen Wu, Julia Furnari, Corina P. Kotidis, Raul Rabadan, Jeanine M. Genkinger, Jeffrey N. Bruce, Peter Canoll, Regina M. Santella, Zhiguo Zhang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Aberrant DNA methylation patterns have been used for cancer detection. However, DNA hemi-methylation, present at about 10% CpG dinucleotides, has been less well studied. Here we show that a majority of differentially hemi-methylated regions

Externí odkaz: https://doaj.org/article/50798e554b5e4411b46deb180e2635df

Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence

Autor: Natanael Zarco, Athanassios Dovas, Virginea de Araujo Farias, Naveen K.H. Nagaiah, Ashley Haddock, Peter A. Sims, Dolores Hambardzumyan, Christian T. Meyer, Peter Canoll, Steven S. Rosenfeld, Rajappa S. Kenchappa

Publikováno v: iScience, Vol 27, Iss 12, Pp 111311- (2024)

Summary: While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, aliserti

Externí odkaz: https://doaj.org/article/fff89d0ebc074d0d9a058fe324ae3cb5

A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma.

Autor: Banu MA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Dovas A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Argenziano MG; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Zhao W; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA., Sperring CP; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Cuervo Grajal H; Spanish National Center for Cardiovascular Research, Madrid, Spain., Liu Z; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA., Higgins DM; Department of Neurological Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Amini M; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Pereira B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Ye LF; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Furnari JL; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Upadhyayula PS; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Zandkarimi F; Department of Biological Sciences, Department of Chemistry and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Nguyen TT; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Teasley D; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Wu PB; Department of Neurological Surgery, UCLA Geffen School of Medicine, Los Angeles, CA, USA., Hai L; Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA., Karan C; Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA., Dowdy T; NCI Neuro-oncology Branch, Bethesda, MD, USA., Razavilar A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Kitajewski J; University of Illinois Cancer Center, Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, USA., Larion M; NCI Neuro-oncology Branch, Bethesda, MD, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Stockwell BR; Department of Biological Sciences, Department of Chemistry and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Sims PA; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA. pas2182@cumc.columbia.edu., Canoll P; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA. pc561@cumc.columbia.edu.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. pc561@cumc.columbia.edu.

Publikováno v: The EMBO journal [EMBO J] 2024 Oct; Vol. 43 (20), pp. 4492-4521. Date of Electronic Publication: 2024 Aug 27.

Human stem cell transplantation models of Alzheimer’s disease

Autor: Nkechime Ifediora, Peter Canoll, Gunnar Hargus

Publikováno v: Frontiers in Aging Neuroscience, Vol 16 (2024)

Alzheimer’s disease (AD) is the most frequent form of dementia. It is characterized by pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition of amyloid β throughout the central nervous system. Animal models have

Externí odkaz: https://doaj.org/article/916d114859f74b4a88719425c2630917