DNA metabarcoding potentially reveals multi-assemblage eutrophication responses in an eastern North American river

Autor: Andrew J. Elmore, Noah Fierer, Cannon Mv, Joseph M. Craine, Steven M. Guinn

Freshwater aquatic ecosystems provide a wide range of ecosystem services, yet provision of these services is increasingly threatened by human activities. Directly quantifying freshwater biotic assemblages has long been a proxy for assessing changing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3501ab0a5352e135a96af2af0a398b1

Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma.

Autor: Ringwalt EM; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, USA., Currier MA; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Glaspell AM; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Chen CY; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Cannon MV; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Cam M; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA., Gross AC; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Gust M; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Wang PY; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA., Boon L; JJP Biologics, 00-728 Warsaw, Poland., Biederman LE; Department of Pathology, Nationwide Children's Hospital, Columbus, OH 43205, USA.; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA., Schwarz E; Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Rajappa P; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Department of Pediatrics and Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA., Lee DA; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Mardis ER; Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA., Carson WE; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; Department of Surgery, Division of Surgical Oncology, The Ohio State University, Columbus, OH 43210, USA., Roberts RD; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Cripe TP; Center for Childhood Cancer Research, Nationwide Children's Hospital, Columbus, OH 43215, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

Publikováno v: Molecular therapy. Oncology [Mol Ther Oncol] 2024 Sep 26; Vol. 32 (4), pp. 200886. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).

Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins.

Autor: Rask GC; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA., Taslim C; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA., Bayanjargal A; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.; Medical Scientist Training Program, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA., Cannon MV; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA., Selich-Anderson J; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA., Crow JC; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA., Duncan A; Salarius Pharmaceuticals, Houston, TX, 77021, USA., Theisen ER; Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 21. Date of Electronic Publication: 2024 May 21.

Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.

Autor: McAloney CA; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Makkawi R; Knight Cancer Institute's, Cancer Early Detection Advanced Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA., Budhathoki Y; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH, USA., Cannon MV; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Franz EM; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH, USA., Gross AC; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Cam M; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Vetter TA; Center for Gene Therapy, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA., Duhen R; Knight Cancer Institute's, Cancer Early Detection Advanced Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA., Davies AE; Knight Cancer Institute's, Cancer Early Detection Advanced Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA. daviesal@ohsu.edu., Roberts RD; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. ryan.roberts@nationwidechildrens.org.; Division of Pediatric Hematology, Oncology, and BMT, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. ryan.roberts@nationwidechildrens.org.; The Ohio State University James Comprehensive Cancer Center, Columbus, OH, USA. ryan.roberts@nationwidechildrens.org.

Publikováno v: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2024 Feb; Vol. 47 (1), pp. 259-282. Date of Electronic Publication: 2023 Sep 07.

Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time.

Autor: Rajan S; Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio.; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio., Zaccaria S; Department of Computer Science, Princeton University, Princeton, New Jersey.; Computational Cancer Genomics Research Group, University College London Cancer Institute, London, United Kingdom.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, United Kingdom., Cannon MV; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio., Cam M; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio., Gross AC; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio., Raphael BJ; Department of Computer Science, Princeton University, Princeton, New Jersey.; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey., Roberts RD; Center for Childhood Cancers and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.; The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio.; Division of Pediatric Hematology, Oncology, and BMT, Nationwide Children's Hospital, Columbus, Ohio.

Publikováno v: Cancer research communications [Cancer Res Commun] 2023 Apr 12; Vol. 3 (4), pp. 564-575. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).