N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.

Autor: Clemen CS; Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.; Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, Medical Faculty, University of Cologne, Cologne, Germany.; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany., Schmidt A; Center for Molecular Medicine and Excellence Cluster 'Cellular Stress Responses in Aging-Associated Diseases' (CECAD), University of Cologne, Cologne, Germany., Winter L; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.; Neuromuscular Research Department, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Canneva F; Experimental Therapy, University Hospital Erlangen and Preclinical Experimental Center, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Wittig I; Functional Proteomics, Medical School, Goethe University, Frankfurt, Germany., Becker L; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Coras R; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Berwanger C; Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany., Hofmann A; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria, Australia., Eggers B; Medical Proteome Center, Medical Faculty, and Medical Proteome Analysis, Center for Protein Diagnostics (PRODI), Ruhr-University Bochum, Bochum, Germany., Marcus K; Medical Proteome Center, Medical Faculty, and Medical Proteome Analysis, Center for Protein Diagnostics (PRODI), Ruhr-University Bochum, Bochum, Germany., Gailus-Durner V; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fuchs H; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., de Angelis MH; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Life Sciences (SoLS), Technical University of Munich, Freising, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Krüger M; Center for Molecular Medicine and Excellence Cluster 'Cellular Stress Responses in Aging-Associated Diseases' (CECAD), University of Cologne, Cologne, Germany., von Hörsten S; Experimental Therapy, University Hospital Erlangen and Preclinical Experimental Center, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Eichinger L; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany., Schröder R; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Publikováno v: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Feb; Vol. 48 (1), pp. e12750. Date of Electronic Publication: 2021 Aug 12.

Evidence of protective effects of recombinant ADAMTS13 in a humanized model of sickle cell disease.

Autor: Rossato P; Baxalta Innovations GmbH, a Takeda company, Vienna., Federti E; Dept of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico GB Rossi, Verona., Matte A; Dept of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico GB Rossi, Verona., Glantschnig H; Baxalta Innovations GmbH, a Takeda company, Vienna., Canneva F; Baxalta Innovations GmbH, a Takeda company, Vienna., Schuster M; Baxalta Innovations GmbH, a Takeda company, Vienna., Coulibaly S; Baxalta Innovations GmbH, a Takeda company, Vienna., Schrenk G; Baxalta Innovations GmbH, a Takeda company, Vienna, Austria; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Naples. gerald.schrenk@takeda.com., Voelkel D; Baxalta Innovations GmbH, a Takeda company, Vienna., Dockal M; Baxalta Innovations GmbH, a Takeda company, Vienna., Plaimauer B; Baxalta Innovations GmbH, a Takeda company, Vienna., Andolfo I; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Naples., Iolascon A; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Naples., Rottensteiner H; Baxalta Innovations GmbH, a Takeda company, Vienna., Gritsch H; Baxalta Innovations GmbH, a Takeda company, Vienna., Scheiflinger F; Baxalta Innovations GmbH, a Takeda company, Vienna., Hoellriegl W; Baxalta Innovations GmbH, a Takeda company, Vienna., Franceschi L; Dept of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico GB Rossi, Verona.

Publikováno v: Haematologica [Haematologica] 2022 Nov 01; Vol. 107 (11), pp. 2650-2660. Date of Electronic Publication: 2022 Nov 01.

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.

Autor: Schulze-Krebs A; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Canneva F; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Stemick J; Department of Molecular Neurology, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Plank AC; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Harrer J; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Bates GP; Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK., Aeschlimann D; Matrix Biology and Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff CF14 4XY, UK., Steffan JS; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA., von Hörsten S; Experimental Therapy, Preclinical Experimental Center, University Hospital Erlangen (UKEr), Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 18; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 18.

Western diet promotes the progression of metabolic dysfunction‐associated steatotic liver disease in association with ferroptosis in male mice.

Autor: Maddie, Nicole¹ (AUTHOR), Chacko, Nefia¹ (AUTHOR), Matatov, David¹ (AUTHOR), Carrillo‐Sepulveda, Maria Alicia¹ (AUTHOR) alicia.sepulveda@nyit.edu

Publikováno v: Physiological Reports. Dec2024, Vol. 12 Issue 23, p1-11. 11p.

Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.

Autor: Plank AC; Department of Child and Adolescent Mental Health, University Hospital Erlangen, Schwabachanlage 6 and 10, 91054, Erlangen, Germany., Frey S; Department of Child and Adolescent Mental Health, University Hospital Erlangen, Schwabachanlage 6 and 10, 91054, Erlangen, Germany., Basedow LA; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany., Solati J; Department of Child and Adolescent Mental Health, University Hospital Erlangen, Schwabachanlage 6 and 10, 91054, Erlangen, Germany., Canneva F; Department Experimental Therapy, University Hospital Erlangen and Preclinical Experimental Animal Center, Friedrich-Alexander-University Erlangen-Nürnberg, Palmsanlage 5, 91054, Erlangen, Germany., von Hörsten S; Department Experimental Therapy, University Hospital Erlangen and Preclinical Experimental Animal Center, Friedrich-Alexander-University Erlangen-Nürnberg, Palmsanlage 5, 91054, Erlangen, Germany., Kratz O; Department of Child and Adolescent Mental Health, University Hospital Erlangen, Schwabachanlage 6 and 10, 91054, Erlangen, Germany., Moll GH; Department of Child and Adolescent Mental Health, University Hospital Erlangen, Schwabachanlage 6 and 10, 91054, Erlangen, Germany., Golub Y; Department of Child and Adolescent Mental Health, University Hospital Erlangen, Schwabachanlage 6 and 10, 91054, Erlangen, Germany. yulia.golub@uniklinikum-dresden.de.; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. yulia.golub@uniklinikum-dresden.de.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2021 Mar 23; Vol. 11 (1), pp. 183. Date of Electronic Publication: 2021 Mar 23.