Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough

Autor: O'Brien, Darragh P., Perez, Ana Cristina Sotomayor, Karst, Johanna, Cannella, Sara E., Enguéné, Véronique Yvette Ntsogo, Hessel, Audrey, Raoux-Barbot, Dorothée, Voegele, Alexis, Subrini, Orso, Davi, Marilyne, Guijarro, J. Inaki, Raynal, Bertrand, Baron, Bruno, England, Patrick, Hernandez, Belen, Ghomi, Mahmoud, Hourdel, Véronique, Malosse, Christian, Chamot-Rooke, Julia, Vachette, Patrice, Durand, Dominique, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre

Publikováno v: In Toxicon July 2018 149:37-44

Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis

Autor: Cannella, Sara E, Ntsogo Enguéné, Véronique Yvette, Davi, Marilyne, Malosse, Christian, Sotomayor Pérez, Ana Cristina, Chamot-Rooke, Julia, Vachette, Patrice, Durand, Dominique, Ladant, Daniel, Chenal, Alexandre

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.42065. ⟨10.1038/srep42065⟩
Scientific Reports, Nature Publishing Group, 2017, 7, pp.42065. 〈10.1038/srep42065〉
Scientific Reports, 2017, 7, pp.42065. ⟨10.1038/srep42065⟩

International audience; Bordetella pertussis, the causative agent of whooping cough, secretes an adenylate cyclase toxin, CyaA, which invades eukaryotic cells and alters their physiology by cAMP overproduction. Calcium is an essential cofactor of Cya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::056b75542da275a66d257546d0b3febe
https://hal-pasteur.archives-ouvertes.fr/pasteur-01508525/document

Calcium tightly regulates disorder-to-order transitions involved in the secretion, folding and functions of the cyaA toxin of Bordetella pertussis, the causative agent of whooping cough

Autor: O'brien, Darragh P., Cannella, Sara E., Durand, Dominique, Ntsogo Eenguene, Véronique Y., Hernandez, Belen, Ghomi, Mahmoud, Subrini, Orso, Hessel, Audrey, Malosse, Christian, Hourdel, Véronique, Vachette, Patrice, Chamot-Rooke, Julia, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre

Publikováno v: In Toxicon July 2018 149:92-92

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Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.

Autor: Cannella SE; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Ntsogo Enguéné VY; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Davi M; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Malosse C; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Sotomayor Pérez AC; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Chamot-Rooke J; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Vachette P; Institut de Biologie Intégrative de la Cellule, UMR 9198, Université Paris-Sud, F-91405 ORSAY Cedex, France., Durand D; Institut de Biologie Intégrative de la Cellule, UMR 9198, Université Paris-Sud, F-91405 ORSAY Cedex, France., Ladant D; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France., Chenal A; Institut Pasteur, UMR CNRS 3528, Chemistry and Structural Biology Department, 75724 PARIS cedex 15, France.

Publikováno v: Scientific reports [Sci Rep] 2017 Feb 10; Vol. 7, pp. 42065. Date of Electronic Publication: 2017 Feb 10.