Výsledky vyhledávání - "Cannabinoids/*pharmacology"

In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice

Autor: Micaela Tirri, Raffaella Arfè, Sabrine Bilel, Giorgia Corli, Beatrice Marchetti, Anna Fantinati, Fabrizio Vincenzi, Fabio De-Giorgio, Cristian Camuto, Monica Mazzarino, Mario Barbieri, Rosa Maria Gaudio, Katia Varani, Pier Andrea Borea, Francesco Botrè, Matteo Marti

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 8030
International journal of molecular sciences, vol. 23, no. 14

3-(1-Naphthalenylmethyl)-1-pentyl-1H-indole (JWH-175) is a synthetic cannabinoid illegally marketed for its psychoactive cannabis-like effects. This study aimed to investigate and compare in vitro and in vivo pharmacodynamic activity of JWH-175 with

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Reverse Pharmacology : Phytocannabinoids, Banned and Restricted Herbals

Autor: Amritpal Singh Saroya

Reverse Pharmacology: Phytocannabinoids, Banned and Restricted Herbals will serve as a tailormade reference guide for the manufacturers and practitioners of herbal drugs. Part A deals with Reverse Pharmacology & Nanophytomedicine and Part B with Phyt

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Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

Autor: John F. Cryan, Ted Dinan, Emilie Petit, John L. Waddington, Niamh Clarke, Orna Tighe, Lieve Desbonnet, Jeremy Walsh, Colm M. P. O’Tuathaigh, Gerard Clarke, Joseph A. Gogos, Claire O'Leary, Maria Karayiorgou

Publikováno v: The International Journal of Neuropsychopharmacology; Vol 15
O'Tuathaigh, C M P, Clarke, G, Walsh, J, Desbonnet, L, Petit, E, O'Leary, C, Tighe, O, Clarke, N, Karayiorgou, M, Gogos, J A, Dinan, T G, Cryan, J F & Waddington, J L 2012, ' Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes ', International Journal of Neuropsychopharmacology, vol. 15, no. 9, pp. 1331-1342 . https://doi.org/10.1017/S1461145711001581

Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of dopamine and disturbance in dopamine function is proposed to be central to the pathogenesis of schizophrenia. Clinical epidemiological studies have indicated cannabis use

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The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

Publikováno v: European Heart Journal
European heart journal (2012).
info:cnr-pdr/source/autori:Montecucco F, Di Marzo V, da Silva RF, Vuilleumier N, Capettini L, Lenglet S, Pagano S, Piscitelli F, Quintao S, Bertolotto M, Pelli G, Galan K, Pilet L, Kuzmanovic K, Burger F, Pane B, Spinella G, Braunersreuther V, Gayet-Ageron A, Pende A, Viviani GL, Palombo D, Dallegri F, Roux-Lombard P, Santos RA, Stergiopulos N, Steffens S, Mach F/titolo:The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques/doi:/rivista:European heart journal/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume
European heart journal
European Heart Journal; Vol 33
European Heart Journal, Vol. 33, No 7 (2012) pp. 846-56

Aims The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 p

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Individual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brain

Autor: Maria Dosi, Christina Spyraki, Andreas Galanopoulos, Marios Marselos, Zeta Papadopoulou-Daifoti, Katerina Antoniou, George G. Nomikos, Alexia Polissidis, Olga Chouliara, Georgia Rentesi, Thomas Hyphantis, Eleni T. Tzavara

Publikováno v: The International Journal of Neuropsychopharmacology. 13:1175-1191

This study explored the behavioural, neurochemical and molecular effects of Delta9-tetrahydrocannabinol (Delta9-THC) and WIN55,212-2, in two rat phenotypes, distinguished on the basis of their vertical activity upon exposure to a novel environment, a

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https://doi.org/10.1017/s1461145709991003

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Marijuana

Autor: Mark S. Gold

Marijuana is the most widely used illicit drug in Amer ica. Some 40% of the adult population has tried mari juana at least once. It is the third largest agricultural commodity in the nation and a $10 billion industry. In many areas of the country

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Drugs of Abuse, Immunity, and AIDS

Autor: Pawel Migula, T.W. Klein, S. Specter

This volume is based on the program of the Second International Conference on Drugs of Abuse, Immunity and AIDS, held in Clearwater Beach, FL in June 1992. The Conference was supported in part by the University of South Florida College of MediCine wi

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Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: a transnational study

Autor: John Attia, Jean-Jacques Déglon, Jacques Besson, Kingsley E Agho, John Ray, Séverine Crettol, Robert Hämmig, Andrew Byrne, Chin B. Eap, Marina Croquette-Krokar, Richard Hallinan, Andrew A. Somogyi

Publikováno v: Hallinan, R; Crettol, S; Agho, K; Attia, J; Besson, J; Croquette-Krokar, M; Hämmig, R; Déglon, J.J.; Byrne, A; Ray, J; Somogyi, A.A.; Eap, C.B. (2009). Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: a transnational study. European journal of clinical pharmacology, 65(11), pp. 1113-1120. Berlin: Springer 10.1007/s00228-009-0706-8
European Journal of Clinical Pharmacology, vol. 65, no. 11, pp. 1113-1120
European Journal of Clinical Pharmacology, Vol. 65, No 11 (2009) pp. 1113-20

PURPOSE: To assess tobacco, alcohol, cannabis and benzodiazepine use in methadone maintenance treatment (MMT) as potential sources of variability in methadone pharmacokinetics. METHODS: Trough plasma (R)- and (S)-methadone concentrations were measure

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The role of the endocannabinoid system in atherosclerosis

Autor: François Mach, Sabine Steffens

Publikováno v: Journal of neuroendocrinology, Vol. 20 Suppl 1 (2008) pp. 53-7

Our current understanding of the pathophysiology of atherosclerosis suggests a prominent role for immune responses from its initiation through its complications. Given the increasing prevalence of cardiovascular risk factors worldwide, there is an ur

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https://pubmed.ncbi.nlm.nih.gov/18426500

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