Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist

Autor: Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N. Goyal, Niraj Kumar Jha, Shreesh Ojha

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The endocannabinoid system has attracted attention as a pharmacological target for several pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of pharmacological studies because modulation of the CB2 receptor (CB2R) can

Externí odkaz: https://doaj.org/article/dedcde7870a14d5e952df396dbfbcee6

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Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential

Autor: Reem Smoum, Christeene Haj, Shira Hirsch, Alina Nemirovski, Zhannah Yekhtin, Benny Bogoslavsky, Gaganjyot Kaur Bakshi, Mukesh Chourasia, Ruth Gallily, Joseph Tam, Raphael Mechoulam

Publikováno v: Molecules, Vol 27, Iss 4, p 1382 (2022)

A series of novel cannabinoid-type derivatives were synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(−)-fenchones with various resorcinols/phenols. The fenchone-resorcinol derivatives were fluorinated using Selectfluor and demethylated using

Externí odkaz: https://doaj.org/article/9049d27258a6472f873e103257af4539

In Vitro Effect of 9-Tetrahydrocannabinol and Cannabidiol on Cancer-Associated Fibroblasts Isolated from Lung Cancer

Autor: Milián L, Monleón-Guinot I, Sancho-Tello M, Galbis JM, Cremades A, Almenar-Ordaz M, Peñaroja-Martinez J, Farras R, Martín de Llano JJ, Carda C, Mata M

Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Universitat Rovira i virgili (URV)

There is evidence that demonstrates the effect of cannabinoid agonists inhibiting relevant aspects in lung cancer, such as proliferation or epithelial-to-mesenchymal transition (EMT). Most of these studies are based on evidence observed in in vitro m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::65cdbd4dd837e355e40af61a6e83e7a0
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4035

Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator

Autor: Ian S. Blagbrough, Husain A. Naqi, Stephen M. Husbands, Christopher R. Pudney

Publikováno v: Analytical Methods. 11:3101-3107

Synthetic cannabinoids are a major class of NPS with a high impact on analytical, forensic and toxicological fields. The main route of administration of synthetic cannabinoids is through inhalation, delivered by smoking a conventional or electronic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00b439be8d684177480540a82d6ff11a
https://doi.org/10.1039/c9ay00722a