Targeting Pf CLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment.

Autor: Brettell SB; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Janha O; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Begen A; KelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Cann G; KelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Sharma S; KelticPharma Therapeutics, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Olaniyan N; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Yelland T; Evotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K., Hole AJ; Evotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K., Alam B; Evotec (U.K.) Ltd, 95 Park Drive, Milton Park, Abingdon, Oxfordshire OX14 4RY, U.K., Mayville E; Department of Microbiology& Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Centre, New York, New York 10032, United States., Gillespie R; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Capper M; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Fidock DA; Department of Microbiology& Immunology and Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Centre, New York, New York 10032, United States., Milligan G; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Clarke DJ; EaSTCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David, Brewster Road, Edinburgh EH9 3FJ, U.K., Tobin AB; Centre for Translational Pharmacology, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K., Jamieson AG; School of Chemistry, The Advanced Research Centre, University of Glasgow, 11 Chapel Lane, Glasgow G11 6EW, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Nov 14; Vol. 67 (21), pp. 18895-18910. Date of Electronic Publication: 2024 Oct 23.

Megakaryocyte- and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels.

Autor: Moss J; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel.; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Ben-Ami R; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel., Shai E; Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Gal-Rosenberg O; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel., Kalish Y; Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Klochendler A; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel., Cann G; GRAIL, LLC., Menlo Park, CA, USA., Glaser B; Endocrinology and Metabolism Service, Hadassah University Medical Center and Faculty of Medicine, the Hebrew University, Jerusalem, Israel., Arad A; Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. arielaar@hadassah.org.il., Shemer R; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel. shemer.ru@mail.huji.ac.il., Dor Y; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel. yuvald@ekmd.huji.ac.il.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 20; Vol. 14 (1), pp. 7542. Date of Electronic Publication: 2023 Nov 20.

A DNA methylation atlas of normal human cell types.

Autor: Loyfer N; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Magenheim J; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Peretz A; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Cann G; GRAIL, Inc., Menlo Park, CA, USA., Bredno J; GRAIL, Inc., Menlo Park, CA, USA., Klochendler A; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Fox-Fisher I; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Shabi-Porat S; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Hecht M; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Pelet T; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Moss J; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel., Drawshy Z; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Amini H; GRAIL, Inc., Menlo Park, CA, USA., Moradi P; GRAIL, Inc., Menlo Park, CA, USA., Nagaraju S; GRAIL, Inc., Menlo Park, CA, USA., Bauman D; Department of Obstetrics and Gynecology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Shveiky D; Department of Obstetrics and Gynecology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Porat S; Department of Obstetrics and Gynecology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Dior U; Department of Obstetrics and Gynecology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Rivkin G; Department of Orthopedics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Or O; Department of Orthopedics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Hirshoren N; Department of Otolaryngology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Carmon E; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Surgery, Samson Assuta Ashdod University Hospital, Ashdod, Israel., Pikarsky A; Surgery Division, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Khalaileh A; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Zamir G; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Grinbaum R; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Abu Gazala M; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Mizrahi I; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Shussman N; Department of General Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Korach A; Department of Cardiothoracic Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Wald O; Department of Cardiothoracic Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Izhar U; Department of Cardiothoracic Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Erez E; Department of Cardiothoracic Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Yutkin V; Department of Urology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Samet Y; Department of Vascular Surgery, Shaare Zedek Medical Center, Jerusalem, Israel., Rotnemer Golinkin D; Department of Endocrinology and Metabolism, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Spalding KL; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Druid H; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Forensic Medicine, The National Board of Forensic Medicine, Stockholm, Sweden., Arner P; Department of Medicine (H7) and Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden., Shapiro AMJ; Department of Surgery and the Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada., Grompe M; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA., Aravanis A; GRAIL, Inc., Menlo Park, CA, USA.; Illumina, Inc., San Diego, CA, USA., Venn O; GRAIL, Inc., Menlo Park, CA, USA., Jamshidi A; GRAIL, Inc., Menlo Park, CA, USA., Shemer R; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Dor Y; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. yuvald@ekmd.huji.ac.il., Glaser B; Department of Endocrinology and Metabolism, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. ben.glaser@mail.huji.ac.il., Kaplan T; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. tommy.kaplan@mail.huji.ac.il.

Publikováno v: Nature [Nature] 2023 Jan; Vol. 613 (7943), pp. 355-364. Date of Electronic Publication: 2023 Jan 04.

Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies.

Autor: Magenheim J; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Equal contributors., Rokach A; Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Equal contributors., Peretz A; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Loyfer N; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Cann G; GRAIL LLC, Menlo Park, CA, USA., Amini H; GRAIL LLC, Menlo Park, CA, USA., Moradi P; GRAIL LLC, Menlo Park, CA, USA., Nagaraju S; GRAIL LLC, Menlo Park, CA, USA., Sameer W; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Cohen A; Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Fogel O; Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem and the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Kuint R; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Abutbul A; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Abu Rmeileh A; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Karameh M; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Cohen Goichman P; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Wald O; Dept of Cardiothoracic Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Korach A; Dept of Cardiothoracic Surgery, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Neiman D; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Fox-Fisher I; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Moss J; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Cohen D; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Piyanzin S; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Ben Ami R; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Quteineh A; The Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel., Golomb E; Dept of Pathology, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel., Shemer R; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Glaser B; Dept of Endocrinology and Metabolism, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Kaplan T; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Fridlender ZG; Hadassah Medical Center, Institute of Pulmonary Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Z.G. Fridlender and Y. Dor contributed equally to this article as lead authors., Dor Y; Dept of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel yuvald@ekmd.huji.ac.il.; Z.G. Fridlender and Y. Dor contributed equally to this article as lead authors.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Nov 03; Vol. 60 (5). Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

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