Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Cankut Çubuk"'
Autor:
Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R. John, Anna E. A. Surace, Rebecca Hands, Liliane Fossati-Jimack, Myles J. Lewis, Costantino Pitzalis
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors of Janus Kinase family (JAKs) are widely used in RA, while inhibitors of other kinase fami
Externí odkaz:
https://doaj.org/article/e05818fb70ad4c61af8d63ded8c3f639
Autor:
Vanessa Pellegrinelli, Elizabeth Figueroa-Juárez, Isabella Samuelson, Mueez U-Din, Sonia Rodriguez-Fdez, Samuel Virtue, Jennifer Leggat, Cankut Çubuk, Vivian J. Peirce, Tarja Niemi, Mark Campbell, Sergio Rodriguez-Cuenca, Joaquin Dopazo Blázquez, Stefania Carobbio, Kirsi A. Virtanen, Antonio Vidal-Puig
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112640- (2023)
Summary: The relevance of extracellular matrix (ECM) remodeling is reported in white adipose tissue (AT) and obesity-related dysfunctions, but little is known about the importance of ECM remodeling in brown AT (BAT) function. Here, we show that a tim
Externí odkaz:
https://doaj.org/article/abc6d1bed4df4ab1bb326033123fcdff
Autor:
Manuela Schmidt, Julia Regina Sondermann, David Gomez-Varela, Cankut Çubuk, Queensta Millet, Myles J. Lewis, John N. Wood, Jing Zhao
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/808d70ea27fc4d60b7d71feeec7e9885
Autor:
Eder Orlando Méndez-Salazar, Janitzia Vázquez-Mellado, Carlos S. Casimiro-Soriguer, Joaquin Dopazo, Cankut Çubuk, Yessica Zamudio-Cuevas, Adriana Francisco-Balderas, Karina Martínez-Flores, Javier Fernández-Torres, Carlos Lozada-Pérez, Carlos Pineda, Austreberto Sánchez-González, Luis H. Silveira, Ana I. Burguete-García, Citlalli Orbe-Orihuela, Alfredo Lagunas-Martínez, Alonso Vazquez-Gomez, Alberto López-Reyes, Berenice Palacios-González, Gabriela Angélica Martínez-Nava
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-13 (2021)
Abstract Objective To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism. Methods Hypervariable V3–V4 regions of
Externí odkaz:
https://doaj.org/article/8545052a4b154fcaadac45df34ac3bb1
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7450 (2023)
The reprogramming of metabolism is a recognized cancer hallmark. It is well known that different signaling pathways regulate and orchestrate this reprogramming that contributes to cancer initiation and development. However, recent evidence is accumul
Externí odkaz:
https://doaj.org/article/af7b62b0c0464a4fa990df9d44cdab2d
Autor:
Kinza Rian, Marina Esteban-Medina, Marta R. Hidalgo, Cankut Çubuk, Matias M. Falco, Carlos Loucera, Devrim Gunyel, Marek Ostaszewski, María Peña-Chilet, Joaquín Dopazo
Publikováno v:
BioData Mining, Vol 14, Iss 1, Pp 1-8 (2021)
Abstract Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map. In this framework, the detailed activity of the human signaling circuits related to the viral infection, covering from the entry
Externí odkaz:
https://doaj.org/article/dd24bdcbd6b448dd8519e1a2a08d6487
Autor:
Kinza Rian, Marta R. Hidalgo, Cankut Çubuk, Matias M. Falco, Carlos Loucera, Marina Esteban-Medina, Inmaculada Alamo-Alvarez, María Peña-Chilet, Joaquín Dopazo
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2968-2978 (2021)
Genome-scale mechanistic models of pathways are gaining importance for genomic data interpretation because they provide a natural link between genotype measurements (transcriptomics or genomics data) and the phenotype of the cell (its functional beha
Externí odkaz:
https://doaj.org/article/dd3db296c08548de912f2d64bded6ef4
Publikováno v:
Biology Direct, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Despite the progress in neuroblastoma therapies the mortality of high-risk patients is still high (40–50%) and the molecular basis of the disease remains poorly known. Recently, a mathematical model was used to demonstrate that
Externí odkaz:
https://doaj.org/article/a44cf393d8bc4e1b87bc9066dd8506f9
Autor:
Pedro G. Ferreira, Manuel Muñoz-Aguirre, Ferran Reverter, Caio P. Sá Godinho, Abel Sousa, Alicia Amadoz, Reza Sodaei, Marta R. Hidalgo, Dmitri Pervouchine, Jose Carbonell-Caballero, Ramil Nurtdinov, Alessandra Breschi, Raziel Amador, Patrícia Oliveira, Cankut Çubuk, João Curado, François Aguet, Carla Oliveira, Joaquin Dopazo, Michael Sammeth, Kristin G. Ardlie, Roderic Guigó
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
RNA levels in post-mortem tissue can differ greatly from those before death. Studying the effect of post-mortem interval on the transcriptome in 36 human tissues, Ferreira et al. find that the response to death is largely tissue-specific and develop
Externí odkaz:
https://doaj.org/article/13343239598e4a75b47fcf977d2aa96c
Autor:
Kasparas Petkevicius, Sam Virtue, Guillaume Bidault, Benjamin Jenkins, Cankut Çubuk, Cecilia Morgantini, Myriam Aouadi, Joaquin Dopazo, Mireille J Serlie, Albert Koulman, Antonio Vidal-Puig
Publikováno v:
eLife, Vol 8 (2019)
White adipose tissue (WAT) inflammation contributes to the development of insulin resistance in obesity. While the role of adipose tissue macrophage (ATM) pro-inflammatory signalling in the development of insulin resistance has been established, it i
Externí odkaz:
https://doaj.org/article/f5d125c747c944b4b0db66dbaee6e08b