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Akademický článek

Efficacy and safety of cangrelor as compared to ticagrelor in patients with ST-elevated myocardial infarction (STEMI): a systematic review and meta-analysis

Autor: Subhro Chakraborty, Debalina Sarkar, Shambo Samrat Samajdar, Pallab Biswas, Debasish Mohapatra, Saptarshi Halder, Mohammad Yunus

Publikováno v: The Egyptian Heart Journal, Vol 76, Iss 1, Pp 1-8 (2024)

Abstract Background This systematic review and meta-analysis aimed to compare the efficacy and safety of cangrelor as compared to ticagrelor in patients with ST-elevated myocardial infarction (STEMI) who underwent percutaneous intervention. Methods P

Externí odkaz: https://doaj.org/article/594978b538fd4392907e14fe63b8f5c2

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Akademický článek

Navigating P2Y12 inhibition in the labyrinth of cardio-oncology care: cangrelor bridging in patients with cancer

Autor: Abdelrahman Ali, Poonam Jewani, Max Bourdillon, Efstratios Koutroumpakis, Shaden Khalaf, Konstantinos Charitakis, Kara Thompson, Konstantinos Marmagkiolis, Anita Deswal, Cezar Iliescu

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Cangrelor, a potent intravenous P2Y12 platelet inhibitor, has demonstrated effectiveness in reducing ischemic events without a corresponding increase in severe bleeding during percutaneous coronary intervention, as evidenced by the CHAMPION-PHOENIX t

Externí odkaz: https://doaj.org/article/9f19bc225cf64f79b4152628c2f67338

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Akademický článek

Cangrelor in contemporary patients with ST-segment elevation myocardial infarction pretreated with Ticagrelor: Pharmacodynamic data from the POMPEII study

Autor: Giuseppe Gargiulo, Plinio Cirillo, Luca Sperandeo, Imma Forzano, Domenico Simone Castiello, Domenico Florimonte, Fiorenzo Simonetti, Roberta Paolillo, Lina Manzi, Alessandra Spinelli, Carmen Anna Maria Spaccarotella, Raffaele Piccolo, Luigi Di Serafino, Anna Franzone, Piera Capranzano, Marco Valgimigli, Giovanni Esposito

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 50, Iss , Pp 101344- (2024)

Background: There are limited data to assess pharmacodynamic (PD) profiles of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and receiving cangrelor after pretreatment with ticagrelor. Methods: The PharmacOdynaMic eff

Externí odkaz: https://doaj.org/article/165157f62580481a8b26660fa57779c6

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Akademický článek

Intravenous cangrelor use for neuroendovascular procedures: a two-center experience and updated systematic review

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

BackgroundThe optimal antiplatelet therapy regimen for certain neuroendovascular procedures remains unclear. This study investigates the safety and feasibility of intravenous dose-adjusted cangrelor in patients undergoing acute neuroendovascular inte

Externí odkaz: https://doaj.org/article/9ceeff397fc74806b5076b8ff9d7b02e

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Akademický článek

Initial Despair and Current Hope of Identifying a Clinically Useful Treatment of Myocardial Reperfusion Injury: Insights Derived from Studies of Platelet P2Y12 Antagonists and Interference with Inflammation and NLRP3 Assembly

Autor: Michael V. Cohen, James M. Downey

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 10, p 5477 (2024)

Myocardial necrosis following the successful reperfusion of a coronary artery occluded by thrombus in a patient presenting with ST-elevation myocardial infarction (STEMI) continues to be a serious problem, despite the multiple attempts to attenuate t

Externí odkaz: https://doaj.org/article/9071d3e377a14c94a6643b3bbf931a49

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Akademický článek

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Akademický článek

Synthesis and Impurity Research of 2-Thioadenosine Monohydrate

Autor: Jing-Jing Xiang, Bi-Bo Jiang, Wen-Qing Sun, Fu-Li Zhang, Jun Yu

Publikováno v: Pharmaceutical Fronts, Vol 05, Iss 02, Pp e84-e90 (2023)

Abstract 2-Thioadenosine monohydrate (1) is a vital intermediate in the synthesis of cangrelor. However, its industrial-scale preparation process and the analysis of the impurities formed during this process remained largely unknown. Herein, cangrel

Externí odkaz: https://doaj.org/article/84ac302ac52342e18adca1845399ef69

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Akademický článek

Rescue of immediate post-transcarotid artery revascularization carotid stent thrombosis due to clopidogrel resistance using flow-reversal and aspiration thrombectomy

Autor: Joyce Lu, MD

Publikováno v: Journal of Vascular Surgery Cases and Innovative Techniques, Vol 9, Iss 2, Pp 101205- (2023)

An 84-year-old patient developed immediate thrombosis of his carotid stent in recovery after transcarotid artery revascularization. In the present report, the technical details about intraoperative management for neurovascular rescue using the transc

Externí odkaz: https://doaj.org/article/8c18f09f89bc4649b54c8bf01a3bce39

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