Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cangcang, Xu"'
Publikováno v:
BMC Pharmacology and Toxicology, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Bladder cancer is the second most common genitourinary malignancy and the eleventh most common cancer worldwide. Dihydroartemisinin (DHA), a first-line antimalarial drug, has been found to have potent antitumor activity. In our pr
Externí odkaz:
https://doaj.org/article/f7f5cb0e03f1425c8f141c89f5d20332
Publikováno v:
Korean Journal of Physiology & Pharmacology; May2024, Vol. 28 Issue 3, p219-227, 9p
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging evidence for their excellent antitumor activities. However, some p
Externí odkaz:
https://doaj.org/article/ea799e7c97124c179920fcb3f8d0e563
Autor:
Wei, Wang, Di, Xiao, Sichun, Zhou, Simeng, Xu, Xinyi, Tang, Xinchong, Zhou, Jinbing, Liu, Cangcang, Xu, Mei, Peng, Xiaoping, Yang
Publikováno v:
Medicinal Chemistry. 18:895-902
Background: In recent years, the anticancer effects of biguanide drugs have received considerable attention. However, the effective concentration of biguanide drugs to kill cancer cells is relatively high. Thus, we focus on structural modification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1028ff9bf4beaa3dd409ef420fe4ce17
https://doi.org/10.2174/1573406418666220210111458
https://doi.org/10.2174/1573406418666220210111458
Autor:
Chenxin Duan, Yanming Chen, Yuxin Zhang, Feifei Liang, Wenwen Liu, Xinyi Xiao, Cangcang Xu, Tao Zhuang, Chao Hao, Yin Chen
Publikováno v:
Crystal Growth & Design. 22:4885-4894
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89e3f15f8ded7f05b8c373b4402e40ac
https://doi.org/10.1021/acs.cgd.2c00370
https://doi.org/10.1021/acs.cgd.2c00370
Publikováno v:
ACS omega. 7(43)
Ten novel mitochondria-targeted dihydroartemisinin ether derivatives were designed, synthesized, and evaluated for antitumor activity against five cancer cell lines in vitro. Profoundly, compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0fc9c5f80b54d658a47432ad94ef39b
https://pubmed.ncbi.nlm.nih.gov/36340114
https://pubmed.ncbi.nlm.nih.gov/36340114
Autor:
Huiling Zhou, Chenxin Duan, Huimin Qin, Chaonan Huang, Jingxuan Hou, Yanming Chen, Jin Zhu, Cangcang Xu, Jian Jin, Tao Zhuang
Publikováno v:
Journal of Molecular Structure. 1281:135101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af23a63d8a4349fe06e81e8ee91de6ee
https://doi.org/10.1016/j.molstruc.2023.135101
https://doi.org/10.1016/j.molstruc.2023.135101
Autor:
Yufang Cao, Simeng Xu, Cangcang Xu, Di Xiao, Zhuliang Chen, Wei Wang, Zhiren Wang, Xiaoping Yang
Publikováno v:
ChemistrySelect. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8fa50c71a4eaa5e9d0f7ee280e1215f
https://doi.org/10.1002/slct.202104250
https://doi.org/10.1002/slct.202104250
Publikováno v:
BMC Pharmacology & Toxicology
Background Bladder cancer is the second most common genitourinary malignancy and the eleventh most common cancer worldwide. Dihydroartemisinin (DHA), a first-line antimalarial drug, has been found to have potent antitumor activity. In our previous st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f443572a5bba673040f6ed539ff55f23
https://pubmed.ncbi.nlm.nih.gov/35057867
https://pubmed.ncbi.nlm.nih.gov/35057867
Publikováno v:
Bioorganicmedicinal chemistry letters. 39
A series of novel artemisinin ester derivatives were designed and synthesized for targeting mitochondria. Cytotoxicity against SMMC-7721, HepG2, OVCAR3, A549 and J82 cancer cell lines was evaluated. Compound 2c (IC50 = 3.0 μM) was the most potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4779c5646932c8de3bb73cc046fa0f47
https://pubmed.ncbi.nlm.nih.gov/33691167
https://pubmed.ncbi.nlm.nih.gov/33691167