Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Canfrán-Duque A"'
Autor:
Zhang, Xinbo, McDonald, Jeffrey G., Aryal, Binod, Canfrán-Duque, Alberto, Goldberg, Emily L., Araldi, Elisa, Ding, Wen, Fan, Yuhua, Thompson, Bonne M., Singh, Abhishek K., Li, Qian, Tellides, George, Ordovás-Montanes, Jose, Milian, Rolando García, Dixit, Vishwa Deep, Ikonen, Elina, Suárez, Yajaira, Fernández-Hernando, Carlos
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2021 Nov . 118(47), 1-11.
Externí odkaz:
https://www.jstor.org/stable/27094027
Autor:
Price, Nathan L., Zhang, Xinbo, Fernández-Tussy, Pablo, Singh, Abhishek K., Burnap, Sean A., Rotllan, Noemi, Goedeke, Leigh, Sun, Jonathan, Canfrán-Duque, Alberto, Aryal, Binod, Mayr, Manuel, Suárez, Yajaira, Fernández-Hernando, Carlos
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2021 Feb 01. 118(5), 1-12.
Externí odkaz:
https://www.jstor.org/stable/27006167
Autor:
Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M. Thompson, Richard G. Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and chol
Externí odkaz:
https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
Autor:
Noemi Rotllan, Xinbo Zhang, Alberto Canfrán-Duque, Leigh Goedeke, Raquel Griñán, Cristina M. Ramírez, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113419- (2022)
Objective: miR-148a-3p (miR-148a) is a hepatic and immune-enriched microRNA (miRNA) that regulates macrophage-related lipoprotein metabolism, cholesterol homeostasis, and inflammation. The contribution of miR-148a-3p to the progression of atheroscler
Externí odkaz:
https://doaj.org/article/2ef32137959041b0bd54a61fb1582ef7
Autor:
Xinbo Zhang, Jonathan Sun, Alberto Canfrán-Duque, Binod Aryal, George Tellides, Ying Ju Chang, Yajaira Suárez, Timothy F. Osborne, Carlos Fernández-Hernando
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Epigenetic modifications of the genome, including DNA methylation, histone methylation/acetylation, and noncoding RNAs, have been reported to play a fundamental role in regulating immune response during the progression of atherosclerosis. SETDB2 is a
Externí odkaz:
https://doaj.org/article/a3e168e7b1064f7b99f145e8a9e45c58
Autor:
Nathan L. Price, Abhishek K. Singh, Noemi Rotllan, Leigh Goedeke, Allison Wing, Alberto Canfrán-Duque, Alberto Diaz-Ruiz, Elisa Araldi, Ángel Baldán, Joao-Paulo Camporez, Yajaira Suárez, Matthew S. Rodeheffer, Gerald I. Shulman, Rafael de Cabo, Carlos Fernández-Hernando
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2133-2145 (2018)
Summary: While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovas
Externí odkaz:
https://doaj.org/article/e344e7cdc5634e7db68d175d5c1581a0
Autor:
Nathan L. Price, Noemi Rotllan, Alberto Canfrán-Duque, Xinbo Zhang, Paramita Pati, Noemi Arias, Jack Moen, Manuel Mayr, David A. Ford, Ángel Baldán, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1317-1330 (2017)
Summary: As an important regulator of macrophage cholesterol efflux and HDL biogenesis, miR-33 is a promising target for treatment of atherosclerosis, and numerous studies demonstrate that inhibition of miR-33 increases HDL levels and reduces plaque
Externí odkaz:
https://doaj.org/article/6a44b423eeff4a9487df7bcc4da530ff
Autor:
Alberto Canfrán‐Duque, Noemi Rotllan, Xinbo Zhang, Marta Fernández‐Fuertes, Cristina Ramírez‐Hidalgo, Elisa Araldi, Lidia Daimiel, Rebeca Busto, Carlos Fernández‐Hernando, Yajaira Suárez
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 9, Pp 1244-1262 (2017)
Abstract Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory disease characterized by the accumulation of lipids and inflammatory cells in the artery wall. Aberrant expression of microRNAs has been implicated in the
Externí odkaz:
https://doaj.org/article/9c10e68c45eb4231aed7f8eaef9ae744
Autor:
Elisa Araldi, Marta Fernández-Fuertes, Alberto Canfrán-Duque, Wenwen Tang, Gary W. Cline, Julio Madrigal-Matute, Jordan S. Pober, Miguel A. Lasunción, Dianqing Wu, Carlos Fernández-Hernando, Yajaira Suárez
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2743-2755 (2017)
Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosynthetic
Externí odkaz:
https://doaj.org/article/b967b084a196471a94bca71436aeadaf
Autor:
Xinbo Zhang, Noemi Rotllan, Alberto Canfrán-Duque, Jonathan Sun, Jakub Toczek, Anna Moshnikova, Shipra Malik, Nathan L. Price, Elisa Araldi, Wen Zhong, Mehran M. Sadeghi, Oleg A. Andreev, Raman Bahal, Yana K. Reshetnyak, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Circ Res
Background: miRNA therapeutics have gained attention during the past decade. These oligonucleotide treatments can modulate the expression of miRNAs in vivo and could be used to correct the imbalance of gene expression found in human diseases such as