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Akademický článek

Oncogenic fusion of BCAR4 activates EGFR signaling and is sensitive to dual inhibition of EGFR/HER2

Autor: Kieun Bae, Jin Hee Kim, Ja Young Lee, Sun-Young Kong, Yun-Hee Kim, Sunshin Kim, Kyong-Ah Yoon

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

We previously reported CD63-BCAR4 fusion as a novel oncogene that significantly enhanced cell migration and metastasis in lung cancer. To identify effective inhibitors of metastatic activity induced by BCAR4 fusion, we screened a drug library of 381

Externí odkaz: https://doaj.org/article/efd9a0f310f74e66b00a30313c8d7abf

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Akademický článek

Sensitivity of EGFR/HER-2 Positive Cells Isolated from Ascitic Fluid of Advanced Ovarian Cancer Patients to EGFR/HER-2 Inhibitors

Autor: Kenny Chitcholtan, Dianne Harker, Bryony Simcock, Peter Sykes

Publikováno v: Applied Sciences, Vol 10, Iss 7, p 2343 (2020)

Background: advanced ovarian cancer often presents with ascites. These ascites contain small clusters of cancer cells, which may contribute greatly to the metastatic potential of ovarian cancer in the peritoneal cavity. Therefore, understanding the u

Externí odkaz: https://doaj.org/article/ba360facdcf340e0be6301e7faa97c40

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Akademický článek

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Identification of antineoplastic agents for oral squamous cell carcinoma: an integrated bioinformatics approach using differential gene expression and network biology

Autor: Abdussalam Usman, Faisal F. Khan

Oral squamous cell carcinoma (OSCC) is the most common malignant epithelial neoplasm and anatomical subtype of head and neck squamous cell carcinoma (HNSCC) with an average 5-year survival rate of less than 50%. To improve the survival rate of OSCC,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fb4cbcfef275cfcf5141b0a8dbdd249
https://doi.org/10.1101/2021.10.14.464376

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Sensitivity of EGFR/HER-2 Positive Cells Isolated from Ascitic Fluid of Advanced Ovarian Cancer Patients to EGFR/HER-2 Inhibitors

Autor: Dianne Harker, Bryony Simcock, Peter Sykes, Kenny Chitcholtan

Publikováno v: Applied Sciences
Volume 10
Issue 7
Applied Sciences, Vol 10, Iss 2343, p 2343 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bfabe8e7a2c5327992c78ad7e58b68

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Akademický článek

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Parathyroid hormone‐like hormone plays a dual role in neuroblastoma depending on PTH1R expression

Autor: Carmen de Torres, Jaume Mora, Carlos J. Rodríguez-Hernández, Marta Garcia, Eliana Gonçalves-Alves, Sara Perez-Jaume, Silvia Mateo-Lozano, Cinzia Lavarino

Publikováno v: Molecular Oncology
Molecular Oncology, Vol 13, Iss 9, Pp 1959-1975 (2019)

We have previously reported the expression of parathyroid hormone‐like hormone (PTHLH) in well‐differentiated, Schwannian stroma‐rich neuroblastic tumors. The aim of this study was to functionally assess the role of PTHLH and its receptor, PTH1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7587909da90f9cd7c1e76d420f5cc96e
http://europepmc.org/articles/PMC6717746

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Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast‐Food Diet Model

Autor: Anne Orr, Swati Banerjee, John Stoops, Bharat Bhushan, William C. Bowen, Kelly Koral, Wendy M. Mars, Shirish Paranjpe, George K. Michalopoulos, Joseph Locker

Publikováno v: Hepatology. 70:1546-1563

Epidermal growth factor receptor (EGFR) is a critical regulator of hepatocyte proliferation and liver regeneration. Our recent work indicated that EGFR can also regulate lipid metabolism during liver regeneration after partial hepatectomy. Based on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a54cc43f26bd6b9471b19ad244417e
https://doi.org/10.1002/hep.30696

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Sulfated magnesium zirconate catalyzed synthesis, antimicrobial, antioxidant, anti-inflammatory, and anticancer activity of benzo[d]thiazole-hydrazone analogues and its molecular docking

Autor: Sivan Velmathi, B.C. Revanasiddappa, Sudhanva M. Srinivasa, Tadimety Madhu Chakrapani Rao, Sanay Naha, L. Parashuram, Swamy Sreenivasa, Shivaraja Govindaiah

Publikováno v: Results in Chemistry, Vol 3, Iss, Pp 100197-(2021)

A comprehensive demonstration of novel catalytic synthetic pathway using sulfated zirconia (solid acid catalyst) to generate a library of bioactive compounds precisely, the benzo[d]thiazole-hydrazone derivatives (4a-n). The compounds are characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aab5be37f3162836f603ff1ef30bb8b
http://www.sciencedirect.com/science/article/pii/S2211715621001028

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A New Advanced In silico Drug Discovery Method for Novel Coronavirus (SARS-CoV-2) with Tensor Decomposition-based Unsupervised Feature Extraction

Autor: Turki Turki, Y-h. Taguchi

Background: COVID-19 is a critical pandemic that has affected human communities worldwide, and there is an urgent need to develop effective drugs. Although there are a large number of candidate drug compounds that may be useful for treating COVID-19,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f16e8119de63e5b2feffb346c793ff7
https://doi.org/10.20944/preprints202004.0524.v2

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