Zobrazeno 1 - 10
of 580
pro vyhledávání: '"Candidate Disease Gene"'
Autor:
Martin Wegner, Marie Hebel, Florian Schmidt, Alexander Marx, Nina Baumgarten, Marcel H. Schulz, Matthias S. Leisegang, Ralf P. Brandes, Jilles Vreeken, Jonathan Göke, Manuel Kaulich
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research (London)
Nucleic Acids Research (London)
Understanding how epigenetic variation in non-coding regions is involved in distal gene-expression regulation is an important problem. Regulatory regions can be associated to genes using large-scale datasets of epigenetic and expression data. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0419655eb6fe2d816f87a044251efaef
https://doi.org/10.1093/nar/gkab798
https://doi.org/10.1093/nar/gkab798
Autor:
Tim Kehl, Andreas Keller, Yongping Li, Eckart Meese, Ernesto Aparicio-Puerta, Viktoria Wagner, Hans-Peter Lenhof, Kamalika Ray, Tobias Fehlmann, Fabian Kern, Nicole Ludwig
Publikováno v:
Nucleic Acids Research
Which genes, gene sets or pathways are regulated by certain miRNAs? Which miRNAs regulate a particular target gene or target pathway in a certain physiological context? Answering such common research questions can be time consuming and labor intensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138f232e3e629746820fde389199aab1
https://doi.org/10.1093/nar/gkab297
https://doi.org/10.1093/nar/gkab297
Autor:
Zhiyun Guo, Yin Zhang, Yiming Zhang, Tailin Guo, Mei Lang, Ran Kang, Zhengtang Tan, Linqi Jin
Publikováno v:
Precision Clinical Medicine. 4:129-135
Feed-forward loops (FFLs) are thought to be one of the most common and important classes of transcriptional network motifs involved in various diseases. Enhancers are cis-regulatory elements that positively regulate protein-coding genes or microRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5881d36eed68698ff8044a302e1463e2
https://doi.org/10.1093/pcmedi/pbab006
https://doi.org/10.1093/pcmedi/pbab006
Autor:
Thomas S. Faber, Elisabeth M. Lodder, Arthur A.M. Wilde, Jürgen Biermann, Christoph Bode, Katja E. Odening, Dawid L. Staudacher, Daniel Duerschmied, Manfred Zehender, Christoph Marschall, Luca Trolese, Johannes Steinfurt, Connie R. Bezzina
Publikováno v:
Europace, 23(5), 775-780. Oxford University Press
Steinfurt, Johannes; Bezzina, Connie R; Biermann, Jürgen; Staudacher, Dawid; Marschall, Christoph; Trolese, Luca; Faber, Thomas S; Duerschmied, Daniel; Zehender, Manfred; Bode, Christoph; Wilde, Arthur A M; Odening, Katja E; Lodder, Elisabeth M (2021). Two siblings with early repolarization syndrome: clinical and genetic characterization by whole-exome sequencing. EP Europace, 23(5), pp. 775-780. Oxford University Press 10.1093/europace/euaa357
Europace
Steinfurt, Johannes; Bezzina, Connie R; Biermann, Jürgen; Staudacher, Dawid; Marschall, Christoph; Trolese, Luca; Faber, Thomas S; Duerschmied, Daniel; Zehender, Manfred; Bode, Christoph; Wilde, Arthur A M; Odening, Katja E; Lodder, Elisabeth M (2021). Two siblings with early repolarization syndrome: clinical and genetic characterization by whole-exome sequencing. EP Europace, 23(5), pp. 775-780. Oxford University Press 10.1093/europace/euaa357
Europace
Aims The early repolarization syndrome (ERS) can cause ventricular fibrillation (VF) and sudden death in young, otherwise healthy individuals. There are limited data suggesting that ERS might be heritable. The aim of this study was to characterize th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e6067188e6d79e742d63447610fda7
https://doi.org/10.1093/europace/euaa357
https://doi.org/10.1093/europace/euaa357
Autor:
Karin Danz, Fabian Kern, Tobias Fehlmann, Hagen von Briesen, Christina Backes, Sylvia Wagner, Eckart Meese, Tim Kehl, Stefanie Rheinheimer, Caroline Diener, Mustafa Kahraman, Oliver Küchler, Hans-Peter Lenhof, Ernesto Aparicio-Puerta, Nicole Ludwig, Martin Hart, Andreas Keller, Lena Krammes
Publikováno v:
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Nucleic Acids Research
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Nucleic Acids Research
MicroRNAs are regulators of gene expression. A wide-spread, yet not validated, assumption is that the targetome of miRNAs is non-randomly distributed across the transcriptome and that targets share functional pathways. We developed a computational an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddc19da0b5bdf6969dff4e6ee02f315
https://doi.org/10.1093/nar/gkaa1161
https://doi.org/10.1093/nar/gkaa1161
Autor:
Lixia Diao, Wei Hong, Yaoming Liu, Wenbo Li, Hang Ruan, Jun Wang, Ying Jing, Leng Han, Zhao Zhang, Shengli Li
Publikováno v:
Nucleic Acids Research
Enhancer RNA (eRNA) is a type of long non-coding RNA transcribed from DNA enhancer regions. Despite critical roles of eRNA in gene regulation, the expression landscape of eRNAs in normal human tissue remains unexplored. Using numerous samples from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc02a74a4c9325e2521000ce1fef98e
https://doi.org/10.1093/nar/gkaa940
https://doi.org/10.1093/nar/gkaa940
Publikováno v:
Nucleic Acids Research
Sammons, M A, Nguyen, T A T, McDade, S S & Fischer, M 2020, ' Tumor suppressor p53: from engaging DNA to target gene regulation ', Nucleic Acids Research, vol. 48, no. 16, pp. 8848-8869 . https://doi.org/10.1093/nar/gkaa666
Sammons, M A, Nguyen, T A T, McDade, S S & Fischer, M 2020, ' Tumor suppressor p53: from engaging DNA to target gene regulation ', Nucleic Acids Research, vol. 48, no. 16, pp. 8848-8869 . https://doi.org/10.1093/nar/gkaa666
The p53 transcription factor confers its potent tumor suppressor functions primarily through the regulation of a large network of target genes. The recent explosion of next generation sequencing protocols has enabled the study of the p53 gene regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1c313510fc6588c12e224a5d3d3b3c
http://europepmc.org/articles/PMC7498329
http://europepmc.org/articles/PMC7498329
Autor:
C. Yan Cheng, Shunna Ge, Changli Shen, Ping Ping, Qilong Yuan, Guihua Liu, An Zhong, Xiang-Feng Chen, Guishuan Wang, Shitao Chen, Qingjun Chu, Jing Zhang, Yang Yang, Yubing Dai, Xinzong Zhang, Xiaoguo Zheng, Yonghan Huang, Yiming Yuan, Yongtong Zhu, Fei Sun, Xiuying Pei, Yong Zhang
Publikováno v:
Human Molecular Genetics. 29:2451-2459
Rare coding variants have been proven to be one of the significant factors contributing to spermatogenic failure in patients with non-obstructive azoospermia (NOA) and severe oligospermia (SO). To delineate the molecular characteristics of idiopathic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d90ff341eee731a4ed91bee0aae8ade
https://doi.org/10.1093/hmg/ddaa101
https://doi.org/10.1093/hmg/ddaa101
Autor:
Baumgarten Nina, Hecker Dennis, Karunanithi Sivarajan, Schmidt Florian, List Markus, Schulz Marcel H.
Publikováno v:
Nucleic Acids Research
The data set contains all regulatory elements (REMs) and the additional information used to create the EpiRegio webserver (https://epiregio.de). The data set consists of 10 tables (CSV-files): GenomeAnnotation: contains information about genomeVersio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c329b5ba92a0cad1531a8dac249c5
http://europepmc.org/articles/PMC7319550
http://europepmc.org/articles/PMC7319550
Autor:
Christopher R. S. Banerji
Publikováno v:
Human Molecular Genetics. 29:2124-2133
Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, inherited skeletal myopathy linked to hypomethylation of the D4Z4 macrosatellite at chromosome 4q35. This epigenetic de-repression permits expression of the transcription factor DUX4, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49805c3390041bf82ffff207858937
https://doi.org/10.1093/hmg/ddaa079
https://doi.org/10.1093/hmg/ddaa079