Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Candice Romany"'
Autor:
Maria E. Vega, Priya H. Dedhia, Meirav Zaks-Zilberman, Karen Keeshan, Sacha N. Uljon, Stephen C. Blacklow, Lanwei Xu, Warren S. Pear, Candice Romany, Olga Shestova
Publikováno v:
Blood. 116(8)
Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation. Tribbles proteins function as adapters to recruit E3 ubiquitin ligases and enhance ubiquitylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fe2cfe021d9a12c97f40cb646497e2
https://pubmed.ncbi.nlm.nih.gov/20410507
https://pubmed.ncbi.nlm.nih.gov/20410507
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
Autor:
Sarah L'Heureux, Candice Romany, Olga Shestova, M. Eden Childs, Phyllis A. Gimotty, Lanwei Xu, Warren S. Pear, Mark Y. Chiang, Gavin Histen, Jon C. Aster
Publikováno v:
The Journal of clinical investigation. 118(9)
Gain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice, but it is unknown whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed0de3af19d392d6925b24f1e6baf07
https://pubmed.ncbi.nlm.nih.gov/18677410
https://pubmed.ncbi.nlm.nih.gov/18677410
Publikováno v:
Blood. 114:7-7
Abstract 7 Notch signaling is activated in ∼70% of human T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) samples and many human and mouse T-ALL cell lines require Notch signals for growth and survival. To gain insight into the role of Notch du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcc39185cb3bbb3470c4158c193330b
https://doi.org/10.1182/blood.v114.22.7.7
https://doi.org/10.1182/blood.v114.22.7.7
Publikováno v:
Blood. 114:395-395
Abstract 395 The Leukemia Stem Cell (LSC) hypothesis proposes that a subset of the cells in the bulk tumor cell population is responsible for leukemia maintenance and propagation. We tested the LSC hypothesis in murine T-cell acute lymphoblastic leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8d627449c8e3b54ac625f26ab431b1
https://doi.org/10.1182/blood.v114.22.395.395
https://doi.org/10.1182/blood.v114.22.395.395
Autor:
Candice Romany, Priya H. Dedhia, Sacha N. Uljon, Karen Keeshan, Olga Shestova, Stephen C. Blacklow, Warren S. Pear, Lanwei Xu, Maria E. Vega
Publikováno v:
Blood. 112:2950-2950
Trib1, Trib2, and Trib3 are mammalian homologues of the Tribbles protein family, an evolutionarily conserved group of proteins that can mediate proteasome-dependent degradation. Evidence suggests that these proteins function as adapters, where they r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91e8b4550e5a70b6b5294f6920714ca6
https://doi.org/10.1182/blood.v112.11.2950.2950
https://doi.org/10.1182/blood.v112.11.2950.2950