Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Candice L Wike"'
Autor:
Graham JM Hickey, Candice L Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J Murphy, Bradley R Cairns
Publikováno v:
eLife, Vol 11 (2022)
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin
Externí odkaz:
https://doaj.org/article/0f077f5c7e104e5a86be865a70d5caec
Autor:
Christopher J. Allender, Candice L. Wike, W. Tanner Porter, Dean Ellis, Darrin Lemmer, Stephanie J. K. Pond, David M. Engelthaler
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract Background Detecting very minor (
Externí odkaz:
https://doaj.org/article/4278e808bab44eafa0d115ae34326ad2
Autor:
Candice L Wike, Hillary K Graves, Reva Hawkins, Matthew D Gibson, Michelle B Ferdinand, Tao Zhang, Zhihong Chen, Damien F Hudson, Jennifer J Ottesen, Michael G Poirier, Jill Schumacher, Jessica K Tyler
Publikováno v:
eLife, Vol 5 (2016)
Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromos
Externí odkaz:
https://doaj.org/article/48487e7bf0d44c30afc1c804f5cab2f7
Autor:
Aneasha F. Whittaker-Tademy, Mengyao Tan, Erez Lieberman Aiden, Hiroyuki Takeda, Bradley R. Cairns, Noelia Díaz, Neva C. Durand, Candice L. Wike, Dana Klatt Shaw, David Grunwald, Ryohei Nakamura, Yixuan Guo, Juan M. Vaquerizas
Publikováno v:
Genome Res
Chromatin architecture mapping in 3D formats has increased our understanding of how regulatory sequences and gene expression are connected and regulated in a genome. The 3D chromatin genome shows extensive remodeling during embryonic development, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69f1c618c949b75e8498b274705cb59
https://doi.org/10.1101/gr.269860.120
https://doi.org/10.1101/gr.269860.120
Autor:
Krista R. Gert, René F. Ketting, Yixuan Guo, Svetlana Lebedeva, Candice L. Wike, Magdalena E. Potok, Edward J. Grow, Bradley R. Cairns, Andrea Pauli
Transposable elements threaten genome stability, and the Piwi-piRNA system has evolved to silence transposons in the germline1–6. However, it remains largely unknown what mechanisms are utilized in early vertebrate embryos prior to germline establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7ff384ab1bc59e1f001b6caf0095ec
https://doi.org/10.1101/2021.11.03.467172
https://doi.org/10.1101/2021.11.03.467172
Autor:
Neva C. Durand, Ryohei Nakamura, Takashi Kondo, Candice L. Wike, Erez Lieberman Aiden, Hiroyuki Takeda, Shinichi Morishita, Tatsuya Tsukahara, Kaori Kondo, Yuichi Motai, Yoichiro Nakatani, Masahiko Kumagai, Haruyo Nishiyama, Bradley R. Cairns, Atsuko Shimada
Publikováno v:
Genome Res
Chromatin looping plays an important role in genome regulation. However, because ChIP-seq and loop-resolution Hi-C (DNA-DNA proximity ligation) are extremely challenging in mammalian early embryos, the developmental stage at which cohesin-mediated lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95340a635a0bb475c6f6d4af47725bb8
https://europepmc.org/articles/PMC8168583/
https://europepmc.org/articles/PMC8168583/
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal how developmental gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438c539ef0f45bdab9af8e37ca07768f
https://doi.org/10.1101/2021.03.16.435592
https://doi.org/10.1101/2021.03.16.435592
Autor:
Graham JM Hickey, Candice L Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J Murphy, Bradley R Cairns
Publikováno v:
eLife
eLife, Vol 11 (2022)
eLife, Vol 11 (2022)
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60017f60c0e95e5095a1e083cf187b56
https://pubmed.ncbi.nlm.nih.gov/34982026
https://pubmed.ncbi.nlm.nih.gov/34982026
Autor:
Candice L Wike, Jessica K. Tyler, Reva Hawkins, Arpit Wason, Hillary K. Graves, Jill M. Schumacher, Jay Gopalakrishnan
The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences of excess free histones. Our accompanying study has shown that a histone modification that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9186fded0aac4be3710964f36b2a28cc
https://europepmc.org/articles/PMC4993543/
https://europepmc.org/articles/PMC4993543/