Zobrazeno 1 - 10 of 62 pro vyhledávání: '"Candice, Johnson"'
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Akademický článek
A Novel Subset of CD95+ Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity
Autor: Candice Johnson, Charles Drummer IV, Huimin Shan, Ying Shao, Yu Sun, Yifan Lu, Fatma Saaoud, Keman Xu, Gayani Nanayakkara, Pu Fang, Zsolt Bagi, Xiaohua Jiang, Eric T. Choi, Hong Wang, Xiaofeng Yang
Publikováno v: Frontiers in Immunology, Vol 11 (2021)
Metabolically healthy obesity (MHO) accounts for roughly 35% of all obese patients. There is no clear consensus that has been reached on whether MHO is a stable condition or merely a transitory period between metabolically healthy lean and metabolica
Externí odkaz: https://doaj.org/article/870a4ca3814c422f95ca054a3d1a9aea
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3
Akademický článek
Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance
Autor: Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v: Journal of Immunology Research, Vol 2021 (2021)
Background. The immune mechanisms underlying low-intensity ultrasound- (LIUS-) mediated suppression of inflammation and tumorigenesis remain poorly determined. Methods. We used microarray datasets from the NCBI GEO DataSet repository and conducted co
Externí odkaz: https://doaj.org/article/3c1e2025dcda46cb97274d331952f0e6
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4
Akademický článek
Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD
Autor: Charles I. V. Drummer, Fatma Saaoud, Yu Sun, Diana Atar, Keman Xu, Yifan Lu, Ying Shao, Candice Johnson, Lu Liu, Huimin Shen, Nirag C. Jhala, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v: Journal of Immunology Research, Vol 2021 (2021)
We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH) microarray data and microarray/RNA-seq data from various mouse models of nonalcoholic fatty liver disease NASH/NAFLD with total 4249 genes examined and made the follo
Externí odkaz: https://doaj.org/article/1fd1eeed479244ef8554a63a366e4bd8
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5
Akademický článek
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis
Autor: Hangfei Fu, Yu Sun, Ying Shao, Jason Saredy, Ramon Cueto, Lu Liu, Charles Drummer, Candice Johnson, Keman Xu, Yifan Lu, Xinyuan Li, Shu Meng, Eric R. Xue, Judy Tan, Nirag C. Jhala, Daohai Yu, Yan Zhou, Kayla J. Bayless, Jun Yu, Thomas J. Rogers, Wenhui Hu, Nathaniel W. Snyder, Jianxin Sun, Xuebin Qin, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Interleukin (IL) 35 is a novel immunosuppressive heterodimeric cytokine in IL-12 family. Whether and how IL-35 regulates ischemia-induced angiogenesis in peripheral artery diseases are unrevealed. To fill this important knowledge gap, we used loss-of
Externí odkaz: https://doaj.org/article/df5786bc9d924b9887e995d716859508
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6
Akademický článek
Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators
Autor: Ming Liu, Jason Saredy, Ruijing Zhang, Ying Shao, Yu Sun, William Y. Yang, Jirong Wang, Lu Liu, Charles Drummer, Candice Johnson, Fatma Saaoud, Yifan Lu, Keman Xu, Li Li, Xin Wang, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
The mechanisms that underlie various inflammation paradoxes, metabolically healthy obesity, and increased inflammations after inflammatory cytokine blockades and deficiencies remain poorly determined. We performed an extensive –omics database minin
Externí odkaz: https://doaj.org/article/15293c66170a4a0b84e67f248fb32515
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7
Akademický článek
End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression
Autor: Ruijing Zhang, Jason Saredy, Ying Shao, Tian Yao, Lu Liu, Fatma Saaoud, William Y. Yang, Yu Sun, Candice Johnson, Charles Drummer, IV, Hangfei Fu, Yifan Lu, Keman Xu, Ming Liu, Jirong Wang, Elizabeth Cutler, Daohai Yu, Xiaohua Jiang, Yafeng Li, Rongshan Li, Lihua Wang, Eric T. Choi, Hong Wang, Xiaofeng Yang
Publikováno v: Redox Biology, Vol 34, Iss , Pp 101460- (2020)
Background: The molecular mechanisms underlying chronic kidney disease (CKD) transition to end-stage renal disease (ESRD) and CKD acceleration of cardiovascular and other tissue inflammations remain poorly determined. Methods: We conducted a comprehe
Externí odkaz: https://doaj.org/article/88f809afc276459f9d4e9c02701e32d1
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8
Akademický článek
A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors
Autor: Luqiao Wang, Gayani Nanayakkara, Qian Yang, Hongmei Tan, Charles Drummer, Yu Sun, Ying Shao, Hangfei Fu, Ramon Cueto, Huimin Shan, Teodoro Bottiglieri, Ya-feng Li, Candice Johnson, William Y. Yang, Fan Yang, Yanjie Xu, Hang Xi, Weiqing Liu, Jun Yu, Eric T. Choi, Xiaoshu Cheng, Hong Wang, Xiaofeng Yang
Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-41 (2017)
Abstract Background Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in
Externí odkaz: https://doaj.org/article/c217ae8ed2654ebfb37228226295f217
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9
Akademický článek
Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study
Autor: Hangfei Fu, Nish Vadalia, Eric R. Xue, Candice Johnson, Luqiao Wang, William Y. Yang, Claudette Sanchez, Jun Nelson, Qian Chen, Eric T. Choi, Jian-Xing Ma, Jun Yu, Hong Wang, Xiaofeng Yang
Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-21 (2017)
Abstract Background Current angiogenic therapies for cancers and cardiovascular diseases have not yet achieved expected benefits, which reflects the need for improved understanding of angiogenesis. In this study, we focused on solving the problem of
Externí odkaz: https://doaj.org/article/82acf15a6e2b4277874048672e752025
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10
Akademický článek
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways
Autor: Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang, Xiao-feng Yang
Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-23 (2017)
Abstract Background It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspas
Externí odkaz: https://doaj.org/article/f05d6fc667b7497f8d4428e17325bcd0
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