Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Candi Trac"'
Autor:
Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, J Andrew Pospisilik, Dustin E Schones
Publikováno v:
eLife, Vol 10 (2021)
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA methyl
Externí odkaz:
https://doaj.org/article/55ac6a019e3446ad92dcb3e7b15bda15
Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism
Autor:
Juan Du, Jingyan Tian, Lili Ding, Candi Trac, Brian Xia, Siming Sun, Dustin E. Schones, Wendong Huang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying the metabolic benefits of VSG h
Externí odkaz:
https://doaj.org/article/d0a659529ecd44d188fc16d8b8d385fd
BACKGROUNDRegulatory innovation is central to the evolution of species. Different nutritional sources are one environmental pressure that can lead to selection for novel regulatory elements. Dietary composition changes, including exposure to “weste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44918ceba16b1a9e2a88ec5d7cd1dff9
https://doi.org/10.1101/2020.11.01.364232
https://doi.org/10.1101/2020.11.01.364232
Autor:
Parijat Senapati, Mark A. LaBarge, Dustin E. Schones, Masaru Miyano, Candi Trac, Amy Leung, Rosalyn W. Sayaman, Mudaser Basam
Luminal epithelial cells (LEps) are a key cell lineage implicated in age-related luminal breast cancers. Alterations to the epigenome are a hallmark of aging cells. However, the extent of age-associated DNA methylation alterations in LEps, and the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059e708c7203f8d690a97bcd797fce29
https://doi.org/10.1101/2020.06.26.170043
https://doi.org/10.1101/2020.06.26.170043
Autor:
Dustin E. Schones, Zhaoxia Chen, Amy Leung, Candi Trac, Rama Natarajan, Kevin R. Costello, Hiroyuki Kato
Publikováno v:
Genome Research. 28:1791-1798
Endogenous retroviruses (ERVs) are ancient viral elements that have accumulated in the genome through retrotransposition events. Although they have lost their ability to transpose, many of the long terminal repeats (LTRs) that originally flanked full
Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism
Autor:
Jingyan Tian, Lili Ding, Dustin E. Schones, Brian Xia, Candi Trac, Siming Sun, Juan Du, Wendong Huang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying the metabolic benefits of VSG have remai
Autor:
Beisi Xu, Darson Lai, Dustin E. Schones, Suresh Cuddapah, Takamitsu Hattori, Ramya K. Mallela, Cynthia C. Jose, Shohei Koide, Candi Trac, Lakshmanan Jagannathan
Publikováno v:
Proceedings of the National Academy of Sciences. 111:14631-14636
Investigations into the genomic landscape of histone modifications in heterochromatic regions have revealed histone H3 lysine 9 dimethylation (H3K9me2) to be important for differentiation and maintaining cell identity. H3K9me2 is associated with gene
Open Chromatin Profiling in Mice Livers Reveals Unique Chromatin Variations Induced by High Fat Diet
Autor:
Ryan L. Setten, Aldons J. Lusis, Dustin E. Schones, Juan Du, Yin Chen, Kevin Brown, Candi Trac, Rama Natarajan, Brian W. Parks, Amy Leung
Publikováno v:
Journal of Biological Chemistry. 289:23557-23567
Metabolic diseases result from multiple genetic and environmental factors. We report here that one manner in which environmental factors can contribute to metabolic disease progression is through modification to chromatin. We demonstrate that high fa
Autor:
Aldons J. Lusis, Dustin E. Schones, Amy Leung, Brian W. Parks, Rama Natarajan, Candi Trac, Juan Du
BackgroundFunctional regulatory regions in eukaryotic genomes are characterized by the disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin accessibility is one of the key mediators of transcriptional regulation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f6de0f825991fb8bb8b41c6f9c6b3
https://doi.org/10.1101/052571
https://doi.org/10.1101/052571