Intermittent Fasting Primes the Tumor Microenvironment and Improves Nanomedicine Delivery in Hepatocellular Carcinoma.

Autor: Becker S; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany.; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Momoh J; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Biancacci I; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Möckel D; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Wang Q; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany., May JN; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Su H; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany., Candels LS; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany., Berres ML; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany., Kiessling F; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Hatting M; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany., Lammers T; Institute for Experimental Molecular Imaging (ExMI), University Hospital RWTH Aachen, 52074, Aachen, Germany., Trautwein C; Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Med III), University Hospital RWTH Aachen, 52074, Aachen, Germany.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2023 Oct; Vol. 19 (43), pp. e2208042. Date of Electronic Publication: 2023 Jun 27.

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.

Autor: Schneider KM; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Mohs A; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Gui W; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Galvez EJC; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany., Candels LS; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Hoenicke L; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany., Muthukumarasamy U; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany., Holland CH; Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg, Germany.; Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Faculty of Medicine, Aachen, Germany., Elfers C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Kilic K; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Schneider CV; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.; The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Schierwagen R; European Foundation for the Study of Chronic Liver Failure (EF-CLIF), 08021, Barcelona, Spain.; Translational Hepatology, Department of Internal Medicine I, Goethe University Frankfurt, 60323, Frankfurt, Germany., Strnad P; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Wirtz TH; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Marschall HU; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Latz E; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127, Bonn, Germany.; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.; German Center for Neurodegenerative Diseases, 53127, Bonn, Germany., Lelouvier B; Vaiomer SAS, Labège, France., Saez-Rodriguez J; Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg, Germany.; Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Faculty of Medicine, Aachen, Germany., de Vos W; Laboratory of Microbiology, Wageningen University, 6708 WE, Wageningen, The Netherlands.; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland., Strowig T; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany., Trebicka J; European Foundation for the Study of Chronic Liver Failure (EF-CLIF), 08021, Barcelona, Spain.; Translational Hepatology, Department of Internal Medicine I, Goethe University Frankfurt, 60323, Frankfurt, Germany., Trautwein C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany. ctrautwein@ukaachen.de.

Publikováno v: Nature communications [Nat Commun] 2022 Jul 08; Vol. 13 (1), pp. 3964. Date of Electronic Publication: 2022 Jul 08.

Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling.

Autor: Schneider KM; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Candels LS; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Hov JR; Norwegian PSC Research Center, Section of Gastroenterology and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital and University of Oslo, Oslo, Norway., Myllys M; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany., Hassan R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Schneider CV; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Wahlström A; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Mohs A; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Zühlke S; Center for Mass Spectrometry (CMS), Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany., Liao L; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.; Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University, Shanghai, China., Elfers C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Kilic K; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Henricsson M; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Molinaro A; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Hatting M; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Zaza A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany., Drasdo D; Institute National de Recherche en Informatique et en Automatique (INRIA), Le Chesnay, France., Frissen M; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Devlin AS; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Gálvez EJC; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany., Strowig T; Helmholtz Centre for Infection Research, Braunschweig, Germany and Hannover Medical School, Hannover, Germany., Karlsen TH; Norwegian PSC Research Center, Section of Gastroenterology and Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital and University of Oslo, Oslo, Norway., Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany., Marschall HU; Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Ghallab A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Trautwein C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany. ctrautwein@ukaachen.de.

Publikováno v: Nature metabolism [Nat Metab] 2021 Sep; Vol. 3 (9), pp. 1228-1241. Date of Electronic Publication: 2021 Sep 22.

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury.

Autor: Schneider KM; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany; Department of Microbiology; Institute for Immunology; and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Elfers C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Ghallab A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Schneider CV; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Galvez EJC; Helmholtz Centre for Infection Research, Braunschweig, Germany; and Hannover Medical School, Hannover, Germany., Mohs A; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Gui W; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Candels LS; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Wirtz TH; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Zuehlke S; Department of Chemistry and Chemical Biology, Institute of Experimental Research (INFU), TU Dortmund University, Dortmund, Germany., Spiteller M; Department of Chemistry and Chemical Biology, Institute of Experimental Research (INFU), TU Dortmund University, Dortmund, Germany., Myllys M; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany., Roulet A; Vaiomer, Labège, France., Ouzerdine A; Vaiomer, Labège, France., Lelouvier B; Vaiomer, Labège, France., Kilic K; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany., Liao L; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany; Department of Anesthesiology and Pain Management, Shanghai East Hospital, Tongji University, Shanghai, China., Nier A; Department of Nutritional Sciences, R.F. Molecular Nutritional Science, University of Vienna, Vienna, Austria., Latz E; Institute for Innate Immunity, University of Bonn, Bonn, Germany., Bergheim I; Department of Nutritional Sciences, R.F. Molecular Nutritional Science, University of Vienna, Vienna, Austria., Thaiss CA; Department of Microbiology; Institute for Immunology; and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany., Strowig T; Helmholtz Centre for Infection Research, Braunschweig, Germany; and Hannover Medical School, Hannover, Germany., Trautwein C; Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany. Electronic address: ctrautwein@ukaachen.de.

Publikováno v: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2021; Vol. 11 (4), pp. 909-933. Date of Electronic Publication: 2020 Nov 12.