Expression of cytochromes P450 and glutathioneS-transferases in human prostate, and the potential for activation of heterocyclic amine carcinogensvia acetyl-coA-, PAPS- and ATP-dependent pathways

Autor: Fred F. Kadlubar, Oscar A. Di Paolo, Susan Nowell, Brian F. Coles, Candee H. Teitel

Publikováno v: International Journal of Cancer. 117:8-13

Dietary factors appear to be involved in the high incidence of prostate cancer in "Westernized" countries, implicating dietary carcinogens such as heterocyclic amines (HAs) in the initiation of prostate carcinogenesis. We examined 24 human prostate s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3316ae01e08e504fd3e771205cbfb049
https://doi.org/10.1002/ijc.21152

Formation and Reduction of Aryl and Heterocyclic Nitroso Compounds and Significance in the Flux of Hydroxylamines

Autor: F. Peter Guengerich, Fred F. Kadlubar, Candee H. Teitel, Donghak Kim

Publikováno v: Chemical Research in Toxicology. 17:529-536

Cytochrome p450 (p450) 1A2 and NADPH-P450 reductase (NPR) catalyzed the oxidation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), with consumption of NADPH. The oxidation rate of NADPH by p450 1A2/NPR increased with time in the presence of IQ until

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83b12489be172737e25f7c2131ce507
https://doi.org/10.1021/tx034267y

Genetic associations with micronutrient levels identified in immune and gastrointestinal networks

Autor: Jim Kaput, Lisa Pence, Beverly McCabe-Sellers, Jerome Turner, Anna J. Williams, Richard D. Beger, Corrado Priami, Jacqueline Pontes Monteiro, Beatrice Shelby, Catherine M. Champagne, Margaret L. Bogle, Baitang Ning, Candee H. Teitel, Melissa J. Morine, Carolyn Wise

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Genes & Nutrition

The discovery of vitamins and clarification of their role in preventing frank essential nutrient deficiencies occurred in the early 1900s. Much vitamin research has understandably focused on public health and the effects of single nutrients to allevi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc8dc330706a5708c9ee3bfc2ca452a

In vitro bioactivation of N -hydroxy-2-amino-α-carboline

Autor: Roberta S. King, Fred F. Kadlubar, Candee H. Teitel

Publikováno v: Carcinogenesis. 21:1347-1354

2-Amino-alpha-carboline (A alpha C) is a mutagenic and carcinogenic heterocyclic amine present in foods cooked at high temperature and in cigarette smoke. The mutagenic activity of A alpha C is dependent upon metabolic activation to N-hydroxy-A alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5207d27dd25474953bf2abd49e82dd76
https://doi.org/10.1093/carcin/21.7.1347

Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl–DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation

Autor: Jackson O. Lay, Fred F. Kadlubar, L.S. Von Tungeln, Glenn Talaska, Dean W. Roberts, Peter P. Fu, Candee H. Teitel, J.E Snawder, Sandra J. Culp, Nicholas P. Lang

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 378:97-112

4-Aminobiphenyl (ABP) is a recognized human bladder carcinogen, whose presence in cigarette smoke results in DNA adduct formation in the human urothelium. Since preliminary studies indicated that even higher levels of ABP–DNA adducts may be present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf395d707e1e0ea7b8bc3bfc6d5fd94f
https://doi.org/10.1016/s0027-5107(97)00101-2